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David A. Mankoff, MD, PhD

David A. Mankoff, MD, PhD Physician

Director, PET Center Vice Chair, Research, Radiology Gerd Muehllehner Professor of Radiology

Dr. Mankoff is employed by Penn Medicine.

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About Dr. David A. Mankoff

Recognized by Best Doctors in America 2015 - 2018

Clinical Specialties

Specialty:

  • Radiology

Programs & Centers:

Board Certification:

  • Nuclear Medicine, 1995

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Amerihealth
  • NJ Medicaid
  • NJ Medicare
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: University of Washington Hospital and Clinics

Memberships

American Association for Cancer Research (AACR), National American College of Radiology, National American Society of Clinical Oncology (ASCO), National AUR RRA Task Force:, National Breastcancer.org, National California Breast Cancer Research Program, National Canada Foundation for Innovation, International CBICA Advisory Committee, Local Department of Defense Breast Cancer Program, National ECOG-ACRIN, National GE Healthcare, National ITMAT TBIC Pilot Grant Reviewer, Local Karmanos Cancer Center, National National Cancer Institute (NCI) Cancer Imaging Program, National National Institutes of Health (NIH), National NCI, National NIH Public-Private Partnership Study Section, National Radiologic Society of North America (RSNA), National RSNA, National Society of Nuclear Medicine (SNM), National Susan G. Komen Foundation, National Susan G. Komen Foundation, National TRACR Advisory Committee, Local TransALLTO breast cancer international trial, International University of Wisconsin Carbone Cancer Center, National Washington University Siteman Cancer Center, National

Hospital Affiliation

Dr. Mankoff is employed by Penn Medicine.

Hospital Privileges:

  • Chester County Hospital: Has privileges to treat patients in the hospital.
  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Molecular Imaging
Breast Cancer
Quantitative Cancer Imaging and Image Analysis
Translational Clinical Trials

Selected Publications:

Makvandi M, Pantel A, Schwartz L, Schubert E, Xu K, Hsieh CJ, Hou C, Kim H, Weng CC, Winters H, Doot R, Farwell MD, Pryma DA, Greenberg RA, Mankoff DA, Simpkins F, Mach RH, Lin LL: A PET imaging agent for evaluating PARP-1 expression in ovarian cancer J Clin Invest 128 (5): 2116-2126,2018.

Peterson LM, O'Sullivan J, Wu QV, Novakova-Jiresova A, Jenkins I, Lee JH, Shields A, Montgomery S, Linden HM, Gralow JR, Gadi VK, Muzi M, Kinahan PE, Mankoff DA, Specht JM: Prospective study of serial (18)F-FDG PET and (18)F-fluoride ((18)F-NaF) PET to predict time to skeletal related events, time-to-progression, and survival in patients with bone-dominant metastatic breast cancer J Nucl Med 59 (12): 1823-1830,2018.

Zhou, R., Pantel, A. R., Li, S., Lieberman, B. P., Ploessl, K., Choi, H., Blankemeyer, E., Lee, H., Kung, H. F., Mach, R. H., Mankoff, D. A.: [18F](2S,4R)4-Fluoroglutamine PET Detects Glutamine Pool Size Changes in Triple-Negative Breast Cancer in Response to Glutaminase Inhibition Cancer Res 77 (6): 1476-1484,2017.

Kurland BF, Peterson LM, Lee JH, Schubert EK, Currin ER, Link JM, Krohn KA, Mankoff DA, Linden HM: Estrogen receptor binding (18F-FES PET) and glycolytic activity (18F-FDG PET) predict progression-free survival on endocrine therapy in patients with ER+ nreast cancer Clin Cancer Res 23 (2): 407-415,2017.

Sellmyer MA, Lee I, Hou C, Lieberman BP, Zeng C, Mankoff DA, Mach RH: Quantitative PET reporter gene imaging with [11C]trimethoprim Mol Ther 25 (1): 120-126,2017.

Zhou R, Bagga P, Nath K, Hariharan H, Mankoff DA, Reddy R: Glutamate-weighted chemical exchange saturation transfer magnetic resonance imaging detects glutaminase inhibition in a mouse model of triple-negative breast cancer Cancer Res 78 (19): 5521-5526,2018.

Mankoff DA, Farwell MD, Clark AS, Pryma DA: Making molecular imaging a clinical tool for precision oncology: A review JAMA Oncol 3 (5): 695-701,2017.

Gerstner ER, Zhang Z, Fink JR, Muzi M, Hanna L, Greco E, Prah M, Schmainda KM, Mintz A, Kostakoglu L, Eikman EA, Ellingson BM, Ratai EM, Sorensen AG, Barboriak DP, Mankoff DA; ACRIN 6684 Trial Group: ACRIN 6684: Assessment of tumor hypoxia in newly diagnosed glioblastoma using 18F-FMISO PET and MRI Clin Cancer Res 22 (20): 5079-5086,2016.

Edmonds CE, Makvandi M, Lieberman BP, Xu K, Zeng C, Li S, Hou C, Lee H, Greenberg RA, Mankoff DA, Mach RH: [(18)F]FluorThanatrace uptake as a marker of PARP1 expression and activity in breast cancer Am J Nucl Med Mol Imaging 6 (1): 94-101,2016.

Kostakoglu L, Duan F, Idowu MO, Jolles PR, Bear HD, Muzi M, Cormack J, Muzi JP, Pryma DA, Specht JM, Hovanessian-Larsen L, Miliziano J, Mallett S, Shields AF, Mankoff DA; ACRIN 668 Investigative Team: A phase II study of 3''-Deoxy-3''-18F-fluorothymidine PET in the assessment of early response of breast cancer to neoadjuvant chemotherapy: results from ACRIN 6688 J Nucl Med 56 (11): 1681-9,2015.

Academic Contact Info

Division of Nuclear Medicine
Department of Radiology
Perelman School of Medicine, University of Pennsylvania
1 Donner, HUP
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 746-4062
Patient appointments: 800-789-7366 (PENN)