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David E. Kaplan, MD, MSc, FACP, FAASLD, AGAF

David E. Kaplan, MD, MSc, FACP, FAASLD, AGAF Physician

Associate Professor of Medicine at the Veteran's Administration Medical Center

Dr. Kaplan is employed by Penn Medicine.

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Clinical Specialties


  • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 2004
  • Internal Medicine, 2000
  • Transplant Hepatology, 2006

Clinical Expertise:

  • Liver Cancer
  • Liver Cirrhosis
  • Liver Diseases
  • Liver Transplantation
  • Viral Hepatitis

Description of Clinical Expertise

Hepatology, viral and non-viral chronic liver disease and cirrhosis, hepatocellular carcinoma, end-stage liver disease

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Texas - Southwest
Residency: Johns Hopkins Hospital
Fellowship: Hospital of the University of Pennsylvania


American Association for the Study of Liver Disease, National American College of Physicians, National American Gastroenterology Association, National Veterans Health Administration Gastroenterology Field Advisory Committee (GI FAC), National Veterans Health Administration, Health Services Research and Development, National

Hospital Affiliation

Dr. Kaplan is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Hepatitis C and hepatocellular carcinoma immunopathogenesis

Selected Publications:

Goldberg DS, French B, Forde KA, Groeneveld PW, Bitterman T, Backus L, Halpern SD, Kaplan DE: Association of distance from a transplant center with access to waitlist placement, receipt of liver transplantation, and survival JAMA 311 (12): 1234-43,2014.

Darpolor MM, Basu SS, Worth A, Nelson DS, Clarke-Katzenberg RH, Glickson JD, Kaplan DE, Blair IA: Aspartate Metabolism Pathway is Differentiable in Human Hepatocellular Carcinoma: Transcriptomics and 13C-Isotope based Metabolomics NMR Biomed 27 (4): 381-9,2014.

Doi H, Tanoue S, Kaplan DE: Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis Clinical Immunology 150 (2): 184-191,2014.

Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA, Aytaman A, Reddy KR, Chang KM: Distinct Features in Natural History and Outcomes of Acute Hepatitis C. J Clin Gastroenterol 49 (4): e31-e40,2015.

Adeyemo O, Doi H, Reddy KR, Kaplan DE: Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection Journal of Viral Hepatitis 20 (7): 453-62,2013.

Kluck J, O'Flynn RM, Kaplan DE, Chang KM: Evaluation of the Significance of Pretreatment Liver Biopsy and Baseline Mental Health Disorder Diagnosis on Hepatitis C Treatment Completion Rates at a Veterans Affairs Medical Center Hepatitis Research and Treatment 2013 : 653976,2013.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R: Adherence to Hepatitis C Virus Therapy in HIV/Hepatitis C-Coinfected Patients AIDS Behav 17 (1): 94-103,2013.

Darpolor MM, Kaplan DE, Pedersen PL, Glickson JD.: Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance Spectroscopy. J Liver: Dis Transplant 1 (1): 2012.

Cai X, Zhai J, Kaplan DE, Zhang Y, Zhou L, Chen X, Qian G, Zhao Q, Li Y, Gao L, Cong W, Zhu M, Yan Z, Shi L, Wu D, Wei L, Shen F, Wu M: Background Progenitor Activation is Associated with Recurrence after Hepatectomy of Combined Hepatocellular Cholangiocarcinoma Hepatology 56(5) : 1804-16,2012.

Reddy KR, Belle SH, Fried MW, Afdhal N, Navarro VJ, Hawke RL, Wahed AS, Doo E, Meyers CM; SyNCH Study Group: Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C Clin Trials 9 (1): 102-112,2012.

Li Y, Siegel DL, Scholler N, Kaplan DE.: Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library BMC Biotechnology 12 (1): 23,2012.

Doi H, Iyer TK, Carpenter EL, Li H, Chang KM, Vonderheide RH, Kaplan DE.: Dysfunctional B-cell activation in cirrhosis due to hepatitis C infection associated with disappearance of CD27+ B-cell population. Hepatology 55 (3): 709-719,2012.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R.: Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study Annals of Internal Medicine 155 (6): 353-360,2011.

Xu Y, Li H, Gao RL, Adeyemo O, Itkin M, Kaplan DE.: Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients. Clinical Immunology 139 (3): 302-313,2011.

Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM: Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134 (7): 1927-37, 1937.e1-2,2008.

Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, Nunes FA, Reddy KR, Chang KM.: Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48 (6): 903-913,2008.

Sugimoto K, Kaplan DE, Ikeda F, Ding J, Schwartz J, Nunes FA, Alter HJ, Chang KM.: Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection Journal of Virology 79 (11): 6976-83,2005.

Kaplan DE, Sugimoto K, Ikeda F, Stadanlick J, Valiga M, Shetty K, Reddy KR, Chang KM.: T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C. Hepatology 41 (6): 1365-75,2005.

Kaplan DE, Sugimoto K, Valiga M, Newton K, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM.: Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132 (2): 654-666,2007.

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Academic Contact Info

421 Curie Boulevard
9 Biomedical Research Building II/III

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)