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David E. Kaplan, MD, MSc, FACP, FAASLD, AGAF

David E. Kaplan, MD, MSc, FACP, FAASLD, AGAF Physician

Associate Professor of Medicine at the Veteran's Administration Medical Center

Dr. Kaplan is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Gastroenterology

Programs & Centers:

Board Certification:

  • Gastroenterology, 2004
  • Internal Medicine, 2000
  • Transplant Hepatology, 2006

Clinical Expertise:

  • Abdominal Bloating
  • Abdominal Disorders
  • Abdominal Distention
  • Abdominal Pain
  • Abnormal Liver Function
  • Abnormal Stool
  • Acute Pancreatitis
  • Alcoholic Liver Disease
  • Altered Bowel Habits
  • Anal Pain
  • Anal Spasm
  • Annular Pancreas
  • Anorexia
  • Autoimmune Enteropathy
  • Autoimmune Hepatitis
  • Barrett's Esophagus
  • Benign Neoplasm of Colon
  • Blood in Stool
  • Bowel Disorders
  • Bowel Dysmotility
  • Bowel incontinence (Fecal Incontinence)
  • Bright Red Blood in Rectum
  • C. Difficile (Clostridium Difficile Diarrhea)
  • Celiac Disease (Celiac Sprue)
  • Cholangitis
  • Cholecystitis
  • Cholelithiasis
  • Cholestasis
  • Chronic Diarrhea
  • Chronic Pancreatitis
  • Colitis
  • Collagenous Colitis
  • Colonic Inertia
  • Colonic Polyps
  • Colonoscopy
  • Constipation
  • Crigler Najjar Syndrome
  • Crohn's Disease
  • Cyclic Vomiting Syndrome
  • Difficulty Swallowing (Dysphagia)
  • Digestive Conditions
  • Diverticular Disease
  • Diverticulitis (Colonic Diverticulitis)
  • Duodenal Ulcer
  • Duodenitis
  • Dyspepsia
  • Early Satiety
  • Eosinophilic Colitis
  • Eosinophilic Enteritis
  • Eosinophilic Esophagitis (EoE)
  • Eosinophilic Gastritis
  • Epigastric Pain
  • Eructation
  • Esophageal Achalasia
  • Esophageal Disorders
  • Esophageal Motility Disorders
  • Esophageal Spasm
  • Esophageal Stricture
  • Esophageal Thickening
  • Esophageal Ulcer
  • Esophageal Varices
  • Esophagitis
  • Esophagus Tumors
  • Fatty Liver Diseases
  • Fecal Impaction
  • Feeding Tube Management
  • Flatulence
  • Focal Nodular Hyperplasia
  • Gallbladder Disorders
  • Gallbladder Polyp
  • Gastric Anomaly
  • Gastric Ulcer
  • Gastritis
  • Gastroenteritis
  • Gastroesophageal Reflux Disease (GERD)
  • Gastrointestinal Amyloid
  • Gastrointestinal Bleeding
  • Gastrointestinal Cancer Screening
  • Gastrojejunal Ulcer
  • Gastroparesis
  • Gastroscopy
  • Giardiasis
  • Gluten Sensitivity
  • H. Pylori Infection
  • Hematemesis
  • Hemochromatosis
  • Hepatitis
  • Hepatitis B
  • Hepatitis C
  • Hepatomegaly
  • Hereditary Nonpolyposis Colorectal Cancer
  • Hiatal Hernia
  • Ileitis
  • Inflammatory Bowel Disease (IBD)
  • Intestinal Obstruction
  • Intestinal Pseudo-Obstruction
  • Intractable Vomiting
  • Irritable Bowel Syndrome
  • Ischemic Colitis
  • Jaundice
  • Lactose Intolerance
  • Liver Cirrhosis
  • Liver Diseases
  • Liver Mass
  • Lymphocytic Colitis
  • Malabsorption
  • Melena
  • Microscopic Colitis
  • Motility Disorders
  • Nausea
  • Non-Alcoholic Fatty Liver Disease
  • Obstipation
  • Obstructive Jaundice
  • Odynophagia
  • Pancreas Divisum
  • Pancreatic Cyst
  • Pancreatic Insufficiency
  • Pancreatic Pseudocyst
  • Pancreaticobiliary Disease
  • Pancreatitis
  • Peptic Ulcer Disease (Stomach Ulcers)
  • Peritonitis
  • Pernicious Anemia
  • Peutz-Jeghers Syndrome
  • Polyposis Syndrome
  • Portal Hypertension
  • Portal Hypertensive Gastropathy
  • Postprandial Diarrhea
  • Proctitis
  • Proctosigmoidoscopy
  • Rectal Bleeding
  • Rectal Disorders
  • Short Bowel Syndrome (Short Gut Syndrome)
  • Sigmoidoscopy
  • Small Bowel Disease
  • Steatorrhea
  • Stomach Cramps
  • Stomach Disorders
  • Swallowing Disorders
  • Toxic Liver Injury
  • Ulcerative Colitis
  • Upper GI Endoscopy
  • Vomiting
  • Whipple's Disease
  • Wilson's Disease
  • Zenker's Diverticulum
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Texas Southwestern Medical Center
Residency: Johns Hopkins Hospital
Fellowship: Hospital of the University of Pennsylvania

Memberships

American Association for the Study of Liver Disease, National American College of Physicians, National American Gastroenterology Association, National Veterans Health Administration Gastroenterology Field Advisory Committee (GI FAC), National

Hospital Affiliation

Dr. Kaplan is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.

Research

Description of Research Expertise:

Hepatitis C and hepatocellular carcinoma immunopathogenesis

Selected Publications:

Goldberg DS, French B, Forde KA, Groeneveld PW, Bitterman T, Backus L, Halpern SD, Kaplan DE: Association of distance from a transplant center with access to waitlist placement, receipt of liver transplantation, and survival JAMA 311 (12): 1234-43,2014.

Darpolor MM, Basu SS, Worth A, Nelson DS, Clarke-Katzenberg RH, Glickson JD, Kaplan DE, Blair IA: Aspartate Metabolism Pathway is Differentiable in Human Hepatocellular Carcinoma: Transcriptomics and 13C-Isotope based Metabolomics NMR Biomed 27 (4): 381-9,2014.

Doi H, Tanoue S, Kaplan DE: Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis Clinical Immunology 150 (2): 184-191,2014.

Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA, Aytaman A, Reddy KR, Chang KM: Distinct Features in Natural History and Outcomes of Acute Hepatitis C. J Clin Gastroenterol 49 (4): e31-e40,2015.

Adeyemo O, Doi H, Reddy KR, Kaplan DE: Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection Journal of Viral Hepatitis 20 (7): 453-62,2013.

Kluck J, O'Flynn RM, Kaplan DE, Chang KM: Evaluation of the Significance of Pretreatment Liver Biopsy and Baseline Mental Health Disorder Diagnosis on Hepatitis C Treatment Completion Rates at a Veterans Affairs Medical Center Hepatitis Research and Treatment 2013 : 653976,2013.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R: Adherence to Hepatitis C Virus Therapy in HIV/Hepatitis C-Coinfected Patients AIDS Behav 17 (1): 94-103,2013.

Darpolor MM, Kaplan DE, Pedersen PL, Glickson JD.: Human Hepatocellular Carcinoma Metabolism: Imaging by Hyperpolarized 13C Magnetic Resonance Spectroscopy. J Liver: Dis Transplant 1 (1): 2012.

Cai X, Zhai J, Kaplan DE, Zhang Y, Zhou L, Chen X, Qian G, Zhao Q, Li Y, Gao L, Cong W, Zhu M, Yan Z, Shi L, Wu D, Wei L, Shen F, Wu M: Background Progenitor Activation is Associated with Recurrence after Hepatectomy of Combined Hepatocellular Cholangiocarcinoma Hepatology 56(5) : 1804-16,2012.

Reddy KR, Belle SH, Fried MW, Afdhal N, Navarro VJ, Hawke RL, Wahed AS, Doo E, Meyers CM; SyNCH Study Group: Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C Clin Trials 9 (1): 102-112,2012.

Li Y, Siegel DL, Scholler N, Kaplan DE.: Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library BMC Biotechnology 12 (1): 23,2012.

Doi H, Iyer TK, Carpenter EL, Li H, Chang KM, Vonderheide RH, Kaplan DE.: Dysfunctional B-cell activation in cirrhosis due to hepatitis C infection associated with disappearance of CD27+ B-cell population. Hepatology 55 (3): 709-719,2012.

Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R.: Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study Annals of Internal Medicine 155 (6): 353-360,2011.

Xu Y, Li H, Gao RL, Adeyemo O, Itkin M, Kaplan DE.: Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients. Clinical Immunology 139 (3): 302-313,2011.

Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM: Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134 (7): 1927-37, 1937.e1-2,2008.

Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, Nunes FA, Reddy KR, Chang KM.: Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48 (6): 903-913,2008.

Sugimoto K, Kaplan DE, Ikeda F, Ding J, Schwartz J, Nunes FA, Alter HJ, Chang KM.: Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection Journal of Virology 79 (11): 6976-83,2005.

Kaplan DE, Sugimoto K, Ikeda F, Stadanlick J, Valiga M, Shetty K, Reddy KR, Chang KM.: T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C. Hepatology 41 (6): 1365-75,2005.

Kaplan DE, Sugimoto K, Valiga M, Newton K, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM.: Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132 (2): 654-666,2007.

View all publications

Academic Contact Info

3400 Civic Center Drive, PCAM 7S GI
Philadelphia, PA 19104
Phone: (215) 349-8222
Patient appointments: 800-789-7366 (PENN)