Penn Medicine Provider
Gastroenterology
David E. Kaplan, MD, MSc, FACP, FAASLD, AGAF
4.9
(226)
Accepting new patients
Sees patients age 18 and up
Penn Gastroenterology Perelman
View 1 additional location

About me

  • Section Chief of Hepatology, Hospital of the University of Pennsylvania
  • Professor of Medicine (Gastroenterology) at the Hospital of the University of Pennsylvania and the Veteran's Administration Medical Center

Dr. Kaplan is board-certified in Internal Medicine, Gastroenterology and Transplant Hepatology. His clinical expertise is in cirrhosis, viral hepatitis, hepatocellular carcinoma and fatty liver. His research interests include translational research in therapy for liver cancer, epidemiological research into the relationship of medication exposures and the natural history of chronic liver disease, and clinical research related to cirrhosis. 

Education and training

  • Medical School: University of Texas Southwestern Medical Center
  • Residency: Johns Hopkins Hospital
  • Fellowship: Hospital of the University of Pennsylvania

What my patients think about me

Average Rating
4.9

226 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

May 2025
5.0
5.0
completely satisfied
April 2025
5.0
5.0
was happy with the whole visit.
April 2025
5.0
5.0
dr kaplan listens and does not rush the visit.
April 2025
5.0
5.0
dr kaplan eased me into his full schedule

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.
Dr. Kaplan is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Kaplan DE, Ripoll C, Thiele M, Fortune BE, Simonetto DA, Garcia-Tsao G, Bosch J. AASLD Practice Guidance on risk stratification and management of portal hypertension and varices in cirrhosis , Hepatology, 79(5): 2024,1180-1211


Expert Panel on Gastrointestinal Imaging; Arif-Tiwari H, Porter KK, Kamel IR, Bashir MR, Fung A, Kaplan DE, McGuire BM, Russo GK, Smith EN, Solnes LB, Thakrar KH, Vij A, Wahab SA, Wardrop RM 3rd, Zaheer A, Carucci LR. ACR Appropriateness Criteria® Abnormal Liver Function Tests , J Am Coll Radiol, 20(11S): 2023,S302-S314


John BV, Dang Y, Kaplan DE, Jou JH, Taddei TH, Spector SA, Martin P, Bastaich DR, Chao HH, Dahman B. Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans With Cirrhosis , Clin Gastroenterol Hepatol: 2023


Serper M, Kaplan DE, Taddei TH, Tapper EB, Cohen JB, Mahmud N. Nonselective beta blockers, hepatic decompensation, and mortality in cirrhosis: A national cohort study , Hepatology, 77(2): 2023,489-500


Mahmud N, Panchal S, Abu-Gazala S, Serper M, Lewis JD, Kaplan DE. Association Between Bariatric Surgery and Alcohol Use-Related Hospitalization and All-Cause Mortality in a Veterans Affairs Cohort , JAMA Surg, 158(2): 2023,162-171


Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Townsend Creasy K, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; EPoS Consortium; VA Million Veteran Program, Rader DJ, Voight BF, Chang KM A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation , Nat Genet, 54(5): 2022,761-771


Goldberg D, Mantero A, Kaplan D, Delgado C, John B, Nuchovich N, Emanuel E, Reese PP. Accurate long-term prediction of death for patients with cirrhosis. , Hepatology, 76(3): 2022,700-711


John BV, Deng Y, Scheinberg A, Mahmud N, Taddei TH, Kaplan D, Labrada M, Baracco G, Dahman B. Association of BNT162b2 mRNA and mRNA-1273 Vaccines With COVID-19 Infection and Hospitalization Among Patients With Cirrhosis. , JAMA Intern Med. , 181(10): 2021,1306-1314


Pazoki R, Vujkovic M, Elliott J, Evangelou E, Gill D, Ghanbari M, van der Most PJ, Pinto RC, Wielscher M, Farlik M, Zuber V, de Knegt RJ, Snieder H, Uitterlinden AG, Lifelines Cohort Study, Lynch JA, Jiang X, Said S, Kaplan DE, Lee KM, Serper M, Carr RM, Tsao PS, Atkinson SR, Dehghan A, Tzoulaki I, Ikram MA, Herzig KH, Jarvelin MR, Alizadeh BZ, O'Donnell CJ, Saleheen D, Voight BF, Chang KM, Thursz MR, Elliott P, VA Million Veteran Program Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. , Nat Comm, 12(1): 2021,2579


Mahmud N, Chapin S, Goldberg DS, Reddy KR, Taddei TH, Kaplan DE. Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort. , J Hepatology, 76(5): 2022,1100-1108


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