Selected Publications
Goldberg D, Mantero A, Kaplan D, Delgado C, John B, Nuchovich N, Emanuel E, Reese PP.: Accurate long-term prediction of death for patients with cirrhosis. Hepatology : 2022 [Epub ahead of print].
Mahmud N, Serper M, Taddei TH, Kaplan DE.: The Association between Proton Pump Inhibitor Exposure and Key Liver-Related Outcomes in Patients with Cirrhosis: A Veterans Affairs Cohort Study. Gastroenterology : 2022 [Epub ahead of print].
Mahmud N, Chapin S, Goldberg DS, Reddy KR, Taddei TH, Kaplan DE.: Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort. J Hepatology : 2022 [Epub ahead of print].
Kaplan DE, Serper M, Mehta R, Fox R, John B, Aytaman A, Baytarian M, Hunt K, Albrecht J, Njei B, Taddei TH; VOCAL Study Group.: Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis. Gastroenterology 156 (6): 1693-1706,2019.
Ioannou George N, Beste Lauren A, Green Pamela K, Singal Amit G, Tapper Elliot B, Waljee Akbar K, Sterling Richard K, Feld Jordan J, Kaplan David E, Taddei Tamar H, Berry Kristin: Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients with Baseline Cirrhosis or High FIB-4 Scores. Gastroenterology 157 (5): 1264-1278.e4,2019.
Serper M, Kaplan DE, Shults J, Reese PP, Beste LA, Taddei TH, Werner RM: Quality measures, all-cause mortality, and healthcare utilization in a national cohort of Veterans with cirrhosis. Hepatology 70 (6): 2062-2074,2019.
Serper M, Weinberg EM, Cohen JB, Reese PP, Taddei TH, Kaplan DE: Mortality and hepatic decompensation in patients with cirrhosis and atrial fibrillation treated with anticoagulation. Hepatology 73 (1): 219-232,2021.
Cai X, Zhai J, Kaplan DE, Zhang Y, Zhou L, Chen X, Qian G, Zhao Q, Li Y, Gao L, Cong W, Zhu M, Yan Z, Shi L, Wu D, Wei L, Shen F, Wu M: Background Progenitor Activation is Associated with Recurrence after Hepatectomy of Combined Hepatocellular Cholangiocarcinoma Hepatology 56(5) : 1804-16,2012.
Emdin Connor A, Haas Mary E, Khera Amit V, Aragam Krishna, Chaffin Mark, Klarin Derek, Hindy George, Jiang Lan, Wei Wei-Qi, Feng Qiping, Karjalainen Juha, Havulinna Aki, Kiiskinen Tuomo, Bick Alexander, Ardissino Diego, Wilson James G, Schunkert Heribert, McPherson Ruth, Watkins Hugh, Elosua Roberto, Bown Matthew J, Samani Nilesh J, Baber Usman, Erdmann Jeanette, Gupta Namrata, Danesh John, Saleheen Danish, Chang Kyong-Mi, Vujkovic Marijana, Voight Ben, Damrauer Scott, Lynch Julie, Kaplan David, Serper Marina, Tsao Philip, Mercader Josep, Hanis Craig, Daly Mark, Denny Joshua, Gabriel Stacey, Kathiresan Sekar: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLoS Genetics 16 (4): e1008629,2020.
Mahmud N, Fricker Z, Serper M, Kaplan DE, Rothstein KD, Goldberg DS.: In-Hospital mortality varies by procedure type among cirrhosis surgery admissions. Liver Int 39 (8): 1394-1399,2019.
Serper M, Choi G, Forde-McLean K, Kaplan DE: Care Delivery and Outcomes among U.S. Veterans with Hepatitis B: A National Cohort Study Hepatology 63 (6): 1774-82,2016.
Kaplan DE, Dai F, Aytaman A, Baytarian M, Fox R, Hunt K, Knott A, Pedrosa M, Pocha C, Mehta R, Duggal M, Skanderson M, Valderrama A, Taddei T: Development and performance of an algorithm to estimate the Child-Turcotte-Pugh Score from a national electronic healthcare database. Clin Gastroenterol Hepatol 13 (13): 2333-41 e1-6,2015.
Asrani SK, Ghabril MS, Kuo A, Merriman RB, Morgan T, Parikh ND, Ovchinsky N, Kanwal F, Volk ML, Ho C, Serper M, Mehta S, Agopian V, Cabrera R, Chernyak V, El-Serag HB, Heimbach J, Ioannou GN, Kaplan D, Marrero J, Mehta N, Singal A, Salem R, Taddei T, Walling AM, Tapper EB.: Quality measures in HCC care by the Practice Metrics Committee of the American Association for the Study of Liver Diseases. Hepatology 75 (5): 1289-1299,2022.
Mahmud N, Fricker Z, Lewis JD, Taddei TH, Goldberg DS, Kaplan DE: Risk Prediction Models for Postoperative Decompensation and Infection in Patients With Cirrhosis: A Veterans Affairs Cohort Study. Clin Gastroenterol Hepatol 20 (5): e1121-1134,2022.
Mahmud N, Fricker Z, Hubbard RA, Ioannou GN, Lewis JD, Taddei TH, Rothstein KD, Serper M, Goldberg DS, Kaplan DE.: Risk Prediction Models for Post-Operative Mortality in Patients With Cirrhosis Hepatology 73 (1): 204-218,2021.
Chang LY, Li Y, Kaplan DE: Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis Scientific Reports 6 : 36862,2016.
Goldberg DS, Taddei TH, Serper M, Mehta R, Dieperink E, Aytaman A, Baytarian M, Fox R, Hunt K, Pedrosa M, Pocha C, Valderrama A, Kaplan DE: Identifying barriers to hepatocellular carcinoma surveillance in a national sample of patients with cirrhosis Hepatology 65 (3): 864-874,2017.
Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA, Aytaman A, Reddy KR, Chang KM: Distinct Features in Natural History and Outcomes of Acute Hepatitis C. J Clin Gastroenterol 49 (4): e31-e40,2015.
Goldberg DS, French B, Forde KA, Groeneveld PW, Bitterman T, Backus L, Halpern SD, Kaplan DE: Association of distance from a transplant center with access to waitlist placement, receipt of liver transplantation, and survival JAMA 311 (12): 1234-43,2014.
Darpolor MM, Basu SS, Worth A, Nelson DS, Clarke-Katzenberg RH, Glickson JD, Kaplan DE, Blair IA: Aspartate Metabolism Pathway is Differentiable in Human Hepatocellular Carcinoma: Transcriptomics and 13C-Isotope based Metabolomics NMR Biomed 27 (4): 381-9,2014.
Doi H, Tanoue S, Kaplan DE: Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis Clinical Immunol 150 (2): 184-191,2014.
Kluck J, O'Flynn RM, Kaplan DE, Chang KM: Evaluation of the Significance of Pretreatment Liver Biopsy and Baseline Mental Health Disorder Diagnosis on Hepatitis C Treatment Completion Rates at a Veterans Affairs Medical Center Hepat Res Treat 2013 : 653976,2013.
Adeyemo O, Doi H, Reddy KR, Kaplan DE: Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection J Viral Hepat 20 (7): 453-62,2013.
Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R: Adherence to Hepatitis C Virus Therapy in HIV/Hepatitis C-Coinfected Patients AIDS Behav 17 (1): 94-103,2013.
Reddy KR, Belle SH, Fried MW, Afdhal N, Navarro VJ, Hawke RL, Wahed AS, Doo E, Meyers CM; SyNCH Study Group: Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C Clin Trials 9 (1): 102-112,2012.
Li Y, Siegel DL, Scholler N, Kaplan DE.: Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library BMC Biotechnology 12 (1): 23,2012.
Doi H, Iyer TK, Carpenter EL, Li H, Chang KM, Vonderheide RH, Kaplan DE.: Dysfunctional B-cell activation in cirrhosis due to hepatitis C infection associated with disappearance of CD27+ B-cell population. Hepatology 55 (3): 709-719,2012.
Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R.: Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study Annals of Internal Medicine 155 (6): 353-360,2011.
Xu Y, Li H, Gao RL, Adeyemo O, Itkin M, Kaplan DE.: Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients.
Clinical Immunol 139 (3): 302-313,2011.
Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM: Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134 (7): 1927-37, 1937.e1-2,2008.
Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, Nunes FA, Reddy KR, Chang KM.: Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48 (6): 903-913,2008.
Sugimoto K, Kaplan DE, Ikeda F, Ding J, Schwartz J, Nunes FA, Alter HJ, Chang KM.: Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection J Virol 79 (11): 6976-83,2005.
Kaplan DE, Sugimoto K, Ikeda F, Stadanlick J, Valiga M, Shetty K, Reddy KR, Chang KM.: T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C. Hepatology 41 (6): 1365-75,2005.
Kaplan DE, Sugimoto K, Valiga M, Newton K, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM.: Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132 (2): 654-666,2007.
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