Selected Publications
Kaplan DE, Ripoll C, Thiele M, Fortune BE, Simonetto DA, Garcia-Tsao G, Bosch J.: AASLD Practice Guidance on risk stratification and management of portal hypertension and varices in cirrhosis Hepatology 79 (5): 1180-1211,2024.
Expert Panel on Gastrointestinal Imaging; Arif-Tiwari H, Porter KK, Kamel IR, Bashir MR, Fung A, Kaplan DE, McGuire BM, Russo GK, Smith EN, Solnes LB, Thakrar KH, Vij A, Wahab SA, Wardrop RM 3rd, Zaheer A, Carucci LR.: ACR Appropriateness Criteria® Abnormal Liver Function Tests J Am Coll Radiol 20 (11S): S302-S314,2023.
John BV, Dang Y, Kaplan DE, Jou JH, Taddei TH, Spector SA, Martin P, Bastaich DR, Chao HH, Dahman B.: Liver Stiffness Measurement and Risk Prediction of Hepatocellular Carcinoma After HCV Eradication in Veterans With Cirrhosis Clin Gastroenterol Hepatol : 2023.
Serper M, Kaplan DE, Taddei TH, Tapper EB, Cohen JB, Mahmud N.: Nonselective beta blockers, hepatic decompensation, and mortality in cirrhosis: A national cohort study Hepatology 77 (2): 489-500,2023.
Mahmud N, Panchal S, Abu-Gazala S, Serper M, Lewis JD, Kaplan DE.: Association Between Bariatric Surgery and Alcohol Use-Related Hospitalization and All-Cause Mortality in a Veterans Affairs Cohort JAMA Surg 158 (2): 162-171,2023.
Vujkovic M, Ramdas S, Lorenz KM, Guo X, Darlay R, Cordell HJ, He J, Gindin Y, Chung C, Myers RP, Schneider CV, Park J, Lee KM, Serper M, Carr RM, Kaplan DE, Haas ME, MacLean MT, Witschey WR, Zhu X, Tcheandjieu C, Kember RL, Kranzler HR, Verma A, Giri A, Klarin DM, Sun YV, Huang J, Huffman JE, Townsend Creasy K, Hand NJ, Liu CT, Long MT, Yao J, Budoff M, Tan J, Li X, Lin HJ, Chen YI, Taylor KD, Chang RK, Krauss RM, Vilarinho S, Brancale J, Nielsen JB, Locke AE, Jones MB, Verweij N, Baras A, Reddy KR, Neuschwander-Tetri BA, Schwimmer JB, Sanyal AJ, Chalasani N, Ryan KA, Mitchell BD, Gill D, Wells AD, Manduchi E, Saiman Y, Mahmud N, Miller DR, Reaven PD, Phillips LS, Muralidhar S, DuVall SL, Lee JS, Assimes TL, Pyarajan S, Cho K, Edwards TL, Damrauer SM, Wilson PW, Gaziano JM, O'Donnell CJ, Khera AV, Grant SFA, Brown CD, Tsao PS, Saleheen D, Lotta LA, Bastarache L, Anstee QM, Daly AK, Meigs JB, Rotter JI, Lynch JA; Regeneron Genetics Center; Geisinger-Regeneron DiscovEHR Collaboration; EPoS Consortium; VA Million Veteran Program, Rader DJ, Voight BF, Chang KM: A multiancestry genome-wide association study of unexplained chronic ALT elevation as a proxy for nonalcoholic fatty liver disease with histological and radiological validation Nat Genet 54 (5): 761-771,2022.
Goldberg D, Mantero A, Kaplan D, Delgado C, John B, Nuchovich N, Emanuel E, Reese PP.: Accurate long-term prediction of death for patients with cirrhosis. Hepatology 76 (3): 700-711,2022.
John BV, Deng Y, Scheinberg A, Mahmud N, Taddei TH, Kaplan D, Labrada M, Baracco G, Dahman B.: Association of BNT162b2 mRNA and mRNA-1273 Vaccines With COVID-19 Infection and Hospitalization Among Patients With Cirrhosis. JAMA Intern Med. 181 (10): 1306-1314,2021.
Pazoki R, Vujkovic M, Elliott J, Evangelou E, Gill D, Ghanbari M, van der Most PJ, Pinto RC, Wielscher M, Farlik M, Zuber V, de Knegt RJ, Snieder H, Uitterlinden AG, Lifelines Cohort Study, Lynch JA, Jiang X, Said S, Kaplan DE, Lee KM, Serper M, Carr RM, Tsao PS, Atkinson SR, Dehghan A, Tzoulaki I, Ikram MA, Herzig KH, Jarvelin MR, Alizadeh BZ, O'Donnell CJ, Saleheen D, Voight BF, Chang KM, Thursz MR, Elliott P, VA Million Veteran Program: Genetic analysis in European ancestry individuals identifies 517 loci associated with liver enzymes. Nat Comm 12 (1): 2579,2021.
Mahmud N, Chapin S, Goldberg DS, Reddy KR, Taddei TH, Kaplan DE.: Statin exposure is associated with reduced development of acute-on-chronic liver failure in a Veterans Affairs cohort. J Hepatology 76 (5): 1100-1108,2022.
Ioannou George N, Beste Lauren A, Green Pamela K, Singal Amit G, Tapper Elliot B, Waljee Akbar K, Sterling Richard K, Feld Jordan J, Kaplan David E, Taddei Tamar H, Berry Kristin: Increased Risk for Hepatocellular Carcinoma Persists Up to 10 Years After HCV Eradication in Patients with Baseline Cirrhosis or High FIB-4 Scores. Gastroenterology 157 (5): 1264-1278.e4,2019.
Kaplan DE, Serper M, Mehta R, Fox R, John B, Aytaman A, Baytarian M, Hunt K, Albrecht J, Njei B, Taddei TH; VOCAL Study Group.: Effects of Hypercholesterolemia and Statin Exposure on Survival in a Large National Cohort of Patients With Cirrhosis. Gastroenterology 156 (6): 1693-1706,2019.
Goldberg DS, French B, Forde KA, Groeneveld PW, Bitterman T, Backus L, Halpern SD, Kaplan DE: Association of distance from a transplant center with access to waitlist placement, receipt of liver transplantation, and survival JAMA 311 (12): 1234-43,2014.
Doi H, Iyer TK, Carpenter EL, Li H, Chang KM, Vonderheide RH, Kaplan DE.: Dysfunctional B-cell activation in cirrhosis due to hepatitis C infection associated with disappearance of CD27+ B-cell population. Hepatology 55 (3): 709-719,2012.
Serper M, Kaplan DE, Shults J, Reese PP, Beste LA, Taddei TH, Werner RM: Quality measures, all-cause mortality, and healthcare utilization in a national cohort of Veterans with cirrhosis. Hepatology 70 (6): 2062-2074,2019.
Serper M, Weinberg EM, Cohen JB, Reese PP, Taddei TH, Kaplan DE: Mortality and hepatic decompensation in patients with cirrhosis and atrial fibrillation treated with anticoagulation. Hepatology 73 (1): 219-232,2021.
Cai X, Zhai J, Kaplan DE, Zhang Y, Zhou L, Chen X, Qian G, Zhao Q, Li Y, Gao L, Cong W, Zhu M, Yan Z, Shi L, Wu D, Wei L, Shen F, Wu M: Background Progenitor Activation is Associated with Recurrence after Hepatectomy of Combined Hepatocellular Cholangiocarcinoma Hepatology 56(5) : 1804-16,2012.
Emdin Connor A, Haas Mary E, Khera Amit V, Aragam Krishna, Chaffin Mark, Klarin Derek, Hindy George, Jiang Lan, Wei Wei-Qi, Feng Qiping, Karjalainen Juha, Havulinna Aki, Kiiskinen Tuomo, Bick Alexander, Ardissino Diego, Wilson James G, Schunkert Heribert, McPherson Ruth, Watkins Hugh, Elosua Roberto, Bown Matthew J, Samani Nilesh J, Baber Usman, Erdmann Jeanette, Gupta Namrata, Danesh John, Saleheen Danish, Chang Kyong-Mi, Vujkovic Marijana, Voight Ben, Damrauer Scott, Lynch Julie, Kaplan David, Serper Marina, Tsao Philip, Mercader Josep, Hanis Craig, Daly Mark, Denny Joshua, Gabriel Stacey, Kathiresan Sekar: A missense variant in Mitochondrial Amidoxime Reducing Component 1 gene and protection against liver disease. PLoS Genetics 16 (4): e1008629,2020.
Mahmud N, Fricker Z, Serper M, Kaplan DE, Rothstein KD, Goldberg DS.: In-Hospital mortality varies by procedure type among cirrhosis surgery admissions. Liver Int 39 (8): 1394-1399,2019.
Serper M, Choi G, Forde-McLean K, Kaplan DE: Care Delivery and Outcomes among U.S. Veterans with Hepatitis B: A National Cohort Study Hepatology 63 (6): 1774-82,2016.
Kaplan DE, Dai F, Aytaman A, Baytarian M, Fox R, Hunt K, Knott A, Pedrosa M, Pocha C, Mehta R, Duggal M, Skanderson M, Valderrama A, Taddei T: Development and performance of an algorithm to estimate the Child-Turcotte-Pugh Score from a national electronic healthcare database. Clin Gastroenterol Hepatol 13 (13): 2333-41 e1-6,2015.
Mahmud N, Serper M, Taddei TH, Kaplan DE: The Association Between Proton Pump Inhibitor Exposure and Key Liver-Related Outcomes in Patients With Cirrhosis: A Veterans Affairs Cohort Study
Gastroenterology 163 (1): 257-269e5,2022.
Asrani SK, Ghabril MS, Kuo A, Merriman RB, Morgan T, Parikh ND, Ovchinsky N, Kanwal F, Volk ML, Ho C, Serper M, Mehta S, Agopian V, Cabrera R, Chernyak V, El-Serag HB, Heimbach J, Ioannou GN, Kaplan D, Marrero J, Mehta N, Singal A, Salem R, Taddei T, Walling AM, Tapper EB.: Quality measures in HCC care by the Practice Metrics Committee of the American Association for the Study of Liver Diseases. Hepatology 75 (5): 1289-1299,2022.
John BV, Deng Y, Schwartz KB, Taddei TH, Kaplan DE, Martin P, Chao HH, Dahman B.: Postvaccination COVID-19 infection is associated with reduced mortality in patients with cirrhosis. Hepatology 76 (1): 126-138,2022.
Tischfield DJ, Gurevich A, Johnson O, Gatmaytan I, Nadolski GJ, Soulen MC, Kaplan DE, Furth E, Hunt SJ, Gade TPF: Transarterial Embolization Modulates the Immune Response within Target and Nontarget Hepatocellular Carcinomas in a Rat Model
Radiology 303 (1): 215-225,2022.
Mahmud N, Fricker Z, Lewis JD, Taddei TH, Goldberg DS, Kaplan DE: Risk Prediction Models for Postoperative Decompensation and Infection in Patients With Cirrhosis: A Veterans Affairs Cohort Study. Clin Gastroenterol Hepatol 20 (5): e1121-1134,2022.
Mahmud N, Fricker Z, Hubbard RA, Ioannou GN, Lewis JD, Taddei TH, Rothstein KD, Serper M, Goldberg DS, Kaplan DE.: Risk Prediction Models for Post-Operative Mortality in Patients With Cirrhosis Hepatology 73 (1): 204-218,2021.
Chang LY, Li Y, Kaplan DE: Endotoxemia contributes to CD27+ memory B-cell apoptosis via enhanced sensitivity to Fas ligation in patients with Cirrhosis Scientific Reports 6 (18): 36862,2016.
Goldberg DS, Taddei TH, Serper M, Mehta R, Dieperink E, Aytaman A, Baytarian M, Fox R, Hunt K, Pedrosa M, Pocha C, Valderrama A, Kaplan DE: Identifying barriers to hepatocellular carcinoma surveillance in a national sample of patients with cirrhosis Hepatology 65 (3): 864-874,2017.
Bunchorntavakul C, Jones LM, Kikuchi M, Valiga ME, Kaplan DE, Nunes FA, Aytaman A, Reddy KR, Chang KM: Distinct Features in Natural History and Outcomes of Acute Hepatitis C. J Clin Gastroenterol 49 (4): e31-e40,2015.
Darpolor MM, Basu SS, Worth A, Nelson DS, Clarke-Katzenberg RH, Glickson JD, Kaplan DE, Blair IA: Aspartate Metabolism Pathway is Differentiable in Human Hepatocellular Carcinoma: Transcriptomics and 13C-Isotope based Metabolomics NMR Biomed 27 (4): 381-9,2014.
Doi H, Tanoue S, Kaplan DE: Peripheral CD27-CD21- B-cells represent an exhausted lymphocyte population in hepatitis C cirrhosis Clinical Immunol 150 (2): 184-191,2014.
Kluck J, O'Flynn RM, Kaplan DE, Chang KM: Evaluation of the Significance of Pretreatment Liver Biopsy and Baseline Mental Health Disorder Diagnosis on Hepatitis C Treatment Completion Rates at a Veterans Affairs Medical Center Hepat Res Treat 2013 (17): 653976,2013.
Adeyemo O, Doi H, Reddy KR, Kaplan DE: Impact of oral silymarin on virus- and non-virus-specific T-cell responses in chronic hepatitis C infection J Viral Hepat 20 (7): 453-62,2013.
Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R: Adherence to Hepatitis C Virus Therapy in HIV/Hepatitis C-Coinfected Patients AIDS Behav 17 (1): 94-103,2013.
Reddy KR, Belle SH, Fried MW, Afdhal N, Navarro VJ, Hawke RL, Wahed AS, Doo E, Meyers CM; SyNCH Study Group: Rationale, challenges, and participants in a Phase II trial of a botanical product for chronic hepatitis C Clin Trials 9 (1): 102-112,2012.
Li Y, Siegel DL, Scholler N, Kaplan DE.: Validation of glypican-3-specific scFv isolated from paired display/secretory yeast display library BMC Biotechnology 12 (1): 23,2012.
Lo Re III V, Teal V, Localio AR, Amorosa VK, Kaplan DE, Gross R.: Relationship between adherence to hepatitis C virus therapy and virologic outcomes: a cohort study Annals of Internal Medicine 155 (6): 353-360,2011.
Xu Y, Li H, Gao RL, Adeyemo O, Itkin M, Kaplan DE.: Expansion of interferon-gamma-producing multifunctional CD4+ T-cells and dysfunctional CD8+ T-cells by glypican-3 peptide library in hepatocellular carcinoma patients.
Clinical Immunol 139 (3): 302-313,2011.
Nakamoto N, Kaplan DE, Coleclough J, Li Y, Valiga ME, Kaminski M, Shaked A, Olthoff K, Gostick E, Price DA, Freeman GJ, Wherry EJ, Chang KM: Functional restoration of HCV-specific CD8 T cells by PD-1 blockade is defined by PD-1 expression and compartmentalization. Gastroenterology 134 (7): 1927-37, 1937.e1-2,2008.
Kaplan DE, Ikeda F, Li Y, Nakamoto N, Ganesan S, Valiga ME, Nunes FA, Reddy KR, Chang KM.: Peripheral virus-specific T-cell interleukin-10 responses develop early in acute hepatitis C infection and become dominant in chronic hepatitis. J Hepatol 48 (6): 903-913,2008.
Sugimoto K, Kaplan DE, Ikeda F, Ding J, Schwartz J, Nunes FA, Alter HJ, Chang KM.: Strain-specific T-cell suppression and protective immunity in patients with chronic hepatitis C virus infection J Virol 79 (11): 6976-83,2005.
Kaplan DE, Sugimoto K, Ikeda F, Stadanlick J, Valiga M, Shetty K, Reddy KR, Chang KM.: T-cell response relative to genotype and ethnicity during antiviral therapy for chronic hepatitis C. Hepatology 41 (6): 1365-75,2005.
Kaplan DE, Sugimoto K, Valiga M, Newton K, Ikeda F, Aytaman A, Nunes FA, Lucey MR, Vance BA, Vonderheide RH, Reddy KR, McKeating JA, Chang KM.: Discordant role of CD4 T-cell response relative to neutralizing antibody and CD8 T-cell responses in acute hepatitis C. Gastroenterology 132 (2): 654-666,2007.
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