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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Hospital of the University of Pennsylvania
3400 Spruce Street
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
"Abnormal Mitochondrial Function in Acute Care Illness in a Translational Approach from Bench to Bedside."We are interested in studying the interaction of mitochondrial function in the area of acute care that includes sepsis and acute toxicological poisoning. We are currently taking a translational approach studying the mitochondria at a cell-based level, to various animal models, all the way to the clinical setting actively enrolling patients with these acute medical conditions with the goal to develop better prognostic measures with the potential for mitochondrial-directed therapy. Our lab has the latest models of the O2k-FluoRespirometer (O2k-Series H), Western blotting, confocal microscopy to study mitochondrial function in both in vitro and in vivo models with a focus on mitochondrial-directed therapies using substrate prodrugs. Relevant in vivo platforms include zebrafish, murine and porcine models of acute critical care illnesses that also combine state of the art physiological monitoring such as PV loop catheters providing realtime physiological data to be linked with cellular function. Our other interests also utilize the use of blood cells as proxy of organ cellular function as a type of biomarker which may provide prognostic function and allow clinicians to better gauge response to therapy. Combining these elements we aim to better understand the complex interactions of both bioenergetics in issues of acute care to better improve patient care and outcomes. This work is supported by:1. K08HL136858 (Jang, PI)
Janowska JI, Piel S, Saliba N, Kim CD, Jang DH, Karlsson M, Kilbaugh TJ, Ehinger JK: N-methyl carbamate-induced mitochondrial respiratory chain complex I dysfunction ex vivo can be alleviated with a cell-permeable succinate prodrug. Toxicol In Vitro : 2020.
Ranganathan A, Owiredu S, Jang DH, Eckmann DM.: Prophylaxis of Mitochondrial Dysfunction Caused by Cellular Decompression from Hyperbaric Exposure Mitochondrion : 2020.
Jang David H, Owiredu Shawn, Ranganathan Abhay, Eckmann David M: Acute decompression following simulated dive conditions alters mitochondrial respiration and motility. American journal of physiology. Cell physiology : 2018.
Jang David H, Orloski Clinton J, Owiredu Shawn, Shofer Frances S, Greenwood John C, Eckmann David M: Alterations in Mitochondrial Function in Blood Cells Obtained from Patients with Sepsis Presenting to an Emergency Department. Shock (Augusta, Ga.) : 2018.
Jang David H, Khatri Utsha G, Mudan Anita, Love Jennifer S, Owiredu Shawn, Eckmann David M: Translational Application of Measuring Mitochondrial Functions in Blood Cells Obtained from Patients with Acute Poisoning. Journal of medical toxicology : official journal of the American College of Medical Toxicology 14 (2): 144-151,2018.
Jang David H, Khatri Utsha G, Shortal Brenna P, Kelly Matthew, Hardy Kevin, Lambert David S, Eckmann David M: Alterations in mitochondrial respiration and reactive oxygen species in patients poisoned with carbon monoxide treated with hyperbaric oxygen. Intensive care medicine experimental 6 (1): 4,2018.
Jang David H, Levy Phillip D, Shofer Frances S, Sun Benjamin, Brown Jeremy: A comparative analysis of National Institutes of Health research support for emergency medicine - 2008 to 2017. The American journal of emergency medicine : 2018.
Jang David H, Greenwood John C, Owiredu Shawn, Ranganathan Abhay, Eckmann David M: Mitochondrial networking in human blood cells with application in acute care illnesses. Mitochondrion : 2017.
Jang David H, Kelly Matthew, Hardy Kevin, Lambert David S, Shofer Frances S, Eckmann David M: A preliminary study in the alterations of mitochondrial respiration in patients with carbon monoxide poisoning measured in blood cells. Clinical toxicology (Philadelphia, Pa.) 55 (6): 579-584,2017.
Jang David H, Greenwood John C, Spyres Meghan B, Eckmann David M: Measurement of Mitochondrial Respiration and Motility in Acute Care: Sepsis, Trauma, and Poisoning. Journal of intensive care medicine 32 (1): 86-94,2017.
Department of Emergency Medicine Research OfficesBlockley Hall423 Guardian Drive, Room 415Lab:Anesthesia and Critical Care Mitochondrial Unit (ACMU)Colket Translational Research BuildingLab 62003501 Civic Center BlvdPhiladelphia, PA 19104