Penn Medicine Provider
David C. Fajgenbaum, MD, MBA, MSc

About me

  • Associate Professor of Medicine (Translational Medicine and Human Genetics)

My Locations

Qualifications and experience

My research

Luke Y. C. Chen, Brian F. Skinnider, Don Wilson, David C. Fajgenbaum Adrenalitis and anasarca in idiopathic multicentric Castleman’s disease , The Lancet., 397(10286): 2021,1749


Sheila K. Pierson, Sushila Shenoy, Ana B. Oromendia, Alexander Gorzewski, Ruth-Anne Langan, Christopher Shield Nabel, Jason R. Ruth, Sophia A. T. Parente, Daniel J. Arenas, Mary Guilfoyle, Manjula Reddy, Michael Weinblatt, Nancy Shadick, Mark Bower, Alessia Dalla Pria, Yasufumi Masaki, Laura Katz, Jason Mezey, Philip Beineke, David Lee, Craig Tendler, Taku Kambayashi, Alexander Fossa, Frits van Rhee, David C. Fajgenbaum Discovery and validation of a novel subgroup and therapeutic target in idiopathic multicentric Castleman disease , Blood Advances., 5(17): 2021,3445-3456


David C. Fajgenbaum & Carl H. June Cytokine Storm , New England Journal of Medicine., 383(23): 2020,2255–2273


Daniel J. Arenas, Katherine Floess, Dale Kobrin, Ruth-Anne Langan Pai, Maya B. Srkalovic, Mark-Avery Tamakloe, Rozena Rasheed, Jasira Ziglar, Johnson Khor, Sophia A. T. Parente, Sheila K. Pierson, Daniel Martinez, Gerald B. Wertheim, Taku Kambayashi, Joseph Baur, David T. Teachey, David C. Fajgenbaum Increased mTOR activation in idiopathic multicentric Castleman disease , Blood., 135(19): 2020,1673–1684


Sheila K. Pierson, Johnson S. Khor, Jasira Ziglar, Amy Liu, Katherine Floess, Erin NaPier, Alexander Gorzewski, Mark-Avery Tamakloe, Victoria Powers, Faizaan Akhter, Eric Haljasmaa, Raj Jayanthan, Arthur Rubenstein, Mileva Repasky, Kojo Elenitoba-Johnson, Jason Ruth, Bette Jacobs, Matthew Streetly, Linus Angenendt, Jose Luis Patier, Simone Ferrero, Pier Luigi Zinzani, Louis Terriou, Corey Casper, Elaine Jaffe, Christian Hoffmann, Eric Oksenhendler, Alexander Fossa, Gordan Srkalovic, Amy Chadburn, Thomas S. Uldrick, Megan Lim, Frits van Rhee, David C. Fajgenbaum ACCELERATE: A Patient-Powered Natural History Study Design Enabling Clinical and Therapeutic Discoveries in a Rare Disorder , Cell Reports Medicine., 1(9): 2020.,100158


Ruth-Anne Langan Pai, Alberto Sada Japp, Michael Gonzalez, Rozena F. Rasheed, Mariko Okumura, Daniel Arenas, Sheila K. Pierson, Victoria Powers, Awo Akosua Kesewa Layman, Charlly Kao, Hakon Hakonarson, Frits van Rhee, Michael R. Betts, Taku Kambayashi, David C. Fajgenbaum Type I IFN response associated with mTOR activation in the TAFRO subtype of idiopathic multicentric Castleman disease , JCI Insight., 5(9): 2020,e135031


Frits van Rhee, Eric Oksenhendler, Gordan Srkalovic, Peter Voorhees, Megan Lim, Makoto Ide, Sophia Parente, Stephen Schey, Matthew Streetly, Raymond Wong, David Wu, Ivan Maillard, Joshua Brandstadter, Nikhil Munshi, Angela Dispenzieri, Kojo S. Elenitoba-Johnson, Alexander Fössa, Mary Jo Lechowicz, Shanmuganathan Chandrakasan, Sheila K. Pierson, Amy Greenway, Sunita Nasta, Kazuyuki Yoshizaki, Razelle Kurzrock, Thomas S. Uldrick, Corey Casper, David C. Fajgenbaum International, evidence-based consensus diagnostic and treatment guidelines for unicentric Castleman Disease , Blood Advances., 4(23): 2020.,6039-6050


Angela Dispenzieri & David C. Fajgenbaum Overview of Castleman Disease , Blood., 135(16): 2020,1353–1364


David C. Fajgenbaum Chasing My Cure: A Doctor's Race to Turn Hope Into Action , Ballantine (an imprint of Penguin Random House).: 2019


David C. Fajgenbaum, Ruth-Anne Langan, Alberto Sada Japp, Helen L. Partridge, Sheila K. Pierson, Amrit Singh, Daniel J. Arenas, Jason R. Ruth, Christopher S. Nabel, Katie Stone, Mariko Okumura, Anthony Schwarer, Fabio Freire Jose, Nelson Hamerschlak, Gerald B. Wertheim, Michael B. Jordan, Adam D. Cohen, Vera Krymskaya, Arthur Rubenstein, Michael R. Betts, Taku Kambayashi, Frits van Rhee, Thomas S. Uldrick Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease , Journal of Clinical Investigation., 129(10): 2019.,4451-4463


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