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David P. Cormode, PhD

David P. Cormode, PhD Researcher

Associate Professor of Radiology

Dr. Cormode is employed by Penn Medicine.

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Memberships

American Chemical Society, National Center for Translational Targeted Therapeutics and Nanomedicine, Local French National Cancer Institute, International German Research Foundation, International Institute for Translational Medicine and Therapeutics, Local International Society of Magnetic Resonance in Medicine, International Israel Science Foundation, International National Institutes of Health, IGIS Study Section, National National Institutes of Health, National Office of the Vice Provost for Research, University of Pennsylvania, Local Society of Molecular Imaging, National

Hospital Affiliation

Dr. Cormode is employed by Penn Medicine.

Research

Description of Research Expertise:

Dr. Cormode's research focuses on the development of novel and multifunctional nanoparticle contrast agents for medical imaging applications. A current major area is the development of gold and bismuth nanoparticles as contrast agents for computed tomography (CT). The nanoparticles can be further modified to have a variety of additional functional properties, such as fluorescence, MRI contrast or therapeutic effects. Related areas of interest are novel computed tomography-based imaging methods, such as dual energy CT, spectral CT and iterative image reconstruction. These technologies are being applied for structural imaging and molecular imaging of the levels of specific cell types and proteins in vivo. These approaches provide enhanced characterization of cardiovascular diseases and cancers, which should allow improved selection of therapies and monitoring of response to treatments.

Undergraduates and master's students, as well as prospective graduate students and postdoctoral fellows are encouraged to email Dr. Cormode if interested in working in our lab.

Selected Publications:

Hsu, Jessica, C.; Cruz, Emma D.;Lau, Kristen C.; Bouché, Mathilde; Maidment, Andrew D. A.; Cormode, David P.: Renally-excretable and size-tunable silver sulfide nanoparticles for dual energy mammography or computed tomography Chemistry of Materials 31 (19): 7845-7854,2019.

Dong, Yuxi C.; Hajfathalian, Maryam; Maidment, Portia S. N.; Hsu, Jessica C.; Naha, Pratap C.; Si-Mohamed, Salim; Breuilly, Marine; Kim, Johoon; Chhour, Peter; Douek, Philippe; Litt, Harold I.; Cormode, David P.: Effect of gold nanoparticle size on their properties as contrast agents for computed tomography Scientific Reports : 2019.

Bouché, Mathilde; Pühringer, Manuel; Iturmendi, Aitziber; Amirshaghaghi, Ahmad; Tsourkas, Andrew; Teasdale, Ian; Cormode, David P.: Activatable hybrid polyphosphazene-AuNP nanoprobe for ROS detection by bimodal PA/CT imaging ACS Applied Materials and Interfaces 11 (32): 28648-28656,2019.

Naha, Pratap C.; Liu, Yuan; Hwang, Geelsu; Huang, Yue; Gubara, Sarah; Jonnakuti, Venkata; Simon-Soro, Aurea; Kim, Dongyeop; Gao, Lizeng; Koo, Hyun.; Cormode, David P.: Dextran coated iron oxide nanoparticles as biomimetic catalysts for localized and pH-activated biofilm disruption ACS Nano 13 (5): 4960-4971,2019.

Hajfathalian, Maryam; Amirshaghaghi, Ahmad; Naha, Pratap C.; Chhour, Peter; Hsu, Jessica, C.; Douglas, Keely; Dong, Yuxi; Sehgal, Chandra M.; Tsourkas, Andrew; Neretina, Svetlana; Cormode, David P.: Wulff in a cage gold nanoparticles as contrast agents for computed tomography and photoacoustic imaging Nanoscale 10 : 18749 – 18757,2018.

Hsu, Jessica, C.; Naha, Pratap C.; Lau, Kristen C.; Chhour, Peter; Hastings, Renee; Moon, Brianna F.; Stein, Joel M.; Witschey, Walter R.; MacDonald, Elizabeth S.; Maidment, Andrew D. A.; Cormode, David P.: An all-in-one nanoparticle (AION) contrast agent for breast cancer screening with DEM-CT-MRI-NIRF imaging Nanoscale 10 : 17236 - 17248,2018.

Kim, Johoon; Bar-Ness, Daniel; Si-Mohamed, Salim; Coulon, Philippe; Blevis, Ira; Douek, Philippe; Cormode, David P.: Assessment of candidate elements for development of spectral photon-counting CT specific contrast agents Scientific Reports : 12119,2018.

Liu, Yuan; Naha, Pratap C.; Hwang, Geelsu; Kim, Dongyeop; Huang, Yue; Simon-Soro, Aurea; Jung, Hoi-In; Ren, Zhi; Li, Yong; Gubara, Sarah; Alawi, Faizan; Zero, Domenick; Hara, Anderson T.; Cormode, David P.; Koo, Hyun: Topical ferumoxytol nanoparticles disrupt biofilms and prevent tooth decay in vivo via intrinsic catalytic activity Nature Communications 9 : 2920,2018.

Cormode, David P.; Si-Mohamed, Salim; Bar-Ness, Daniel; Sigovan, Monica; Naha, Pratap C.; Balegamire, Joelle; Lavenne, Franck; Coulon, Philippe; Roessl, Ewald; Bartels, Matthias; Rokni, Michal; Blevis, Ira; Boussel, Loic; Douek, Philippe: Multicolor spectral photon-counting computed tomography: in vivo dual contrast imaging with a high count rate scanner Scientific Reports 7 : 4784,2017.

Chhour, Peter; Kim, Johoon; Benardo, Barbara; Tovar, Alfredo; Mian, Shaameen; Litt, Harold I.; Ferrari, Victor A.; Cormode, David P.: Effect of gold nanoparticle size and coating on labeling monocytes for CT tracking Bioconjugate Chemistry 28 (1): 260-269,2017.

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Academic Contact Info

Hospital of the University of Pennsylvania
Department of Radiology
3400 Spruce Street, 1 Silverstein

Philadelphia, PA 19104
Phone: (215) 615-4656