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Daria V. Babushok, MD, PHD

Daria V. Babushok, MD, PHD Physician

Assistant Professor of Pediatrics Assistant Professor of Medicine

Dr. Babushok is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Hematology
  • Medical Oncology

Programs & Centers:

Board Certification:

  • Hematology, 2014
  • Internal Medicine, 2011

Clinical Expertise:

  • Aplastic Anemia
  • Bone Marrow Failure Syndrome (BMFS)
  • Cancer Genetic Testing
  • Chronic Myeloid Leukemia (CML)
  • Chronic Myelomonocytic Leukemia (CMML)
  • Dyskeratosis Congenita (DC)
  • Fanconi Anemia (FA)
  • Myelodysplastic Syndromes (MDS)
  • Myelofibrosis (MF)
  • Myeloproliferative Disease
  • Myeloproliferative Neoplasms (MPN)
  • Paroxysmal Nocturnal Hemoglobinuria (PNH)
  • Polycythemia Vera (PV)
  • Shwachman-Diamond Syndrome

Description of Clinical Expertise

Bone marrow failure syndromes (inherited and acquired), acquired aplastic anemia, paroxysmal nocturnall hemoglobinuria, clonal hematopoiesis, MDS/AML predisposition syndromes, MPN predisposition syndromes, myeloproliferative neoplasms

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Massachusetts General Hospital
Fellowship: Hospital of the University of Pennsylvania

Memberships

Alpha Omega Alpha, National American Association for Cancer Research, International American Society of Clinical Oncology, International American Society of Hematology, National Federation of Clinical Immunology Societies, National

Hospital Affiliation

Dr. Babushok is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

RESEARCH INTERESTS:
The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.

We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the development of clonal hematopoiesis in bone marrow failure and aging.

KEYWORDS:
Clonal hematopoiesis, bone marrow failure, aplastic anemia, PNH, malignant predisposition to MDS and leukemia

ROTATION PROJECTS:
We are always looking for talented individuals who are passionate about science. There are opportunities to contribute at every level, and we welcome inquiries from undergraduate and graduate students, postdoctoral scientists, and medical students, residents, and fellows. Please contact Daria.Babushok at uphs.upenn.edu to discuss research opportunities.

SEE BABUSHOK LAB WEBSITE

LAB MEMBERS:
Kathy Guo – Research Specialist
Natasha Stanley – Research Specialist

MEDICAL STUDENT RESEARCHERS:
Taylor Linaburg – Medical Student
Tristan Lim - Medical Student

Selected Publications:

Babushok DV: A Brief, But Comprehensive, Guide to Clonal Evolution in Aplastic Anemia Hematology 2018 : 2018.

Aynardi J, Manur R, Hess PR, Chekol S, Morrissette JJD, Babushok D, Hexner E, Rogers HJ, Hsi ED, Margolskee E, Orazi A, Hasserjian R, Bagg A.: JAK2 V617F-positive acute myeloid leukaemia (AML): a comparison between de novo AML and secondary AML transformed from an underlying myeloproliferative neoplasm. A study from the Bone Marrow Pathology Group. Br J Haematol. : 2018.

Soderquist CR, Ewalt MD, Czuchlewski DR, Geyer JT, Rogers HJ, Hsi ED, Wang SA, Bueso-Ramos CE, Orazi A, Arber DA, Hexner EO, Babushok DV, Bagg A.: Myeloproliferative Neoplasms with Concurrent BCR-ABL1 Translocation and JAK2 V617F Mutation: a Multi-institutional Study from the Bone Marrow Pathology Group. Mod Pathol 31 (5): 690-704,2018.

Babushok D, Bessler M.: Aplastic Anemia and Pure Red Cell Aplasia. Chapter 18. In Anemia: Pathophysiology, Diagnosis and Management. Cambridge University Press : 2018.

Sarthy J, Zha J, Babushok D, Shenoy A, Fan J-M, Wertheim G, Himebach A, Munchel A, Taraseviciute A, Yang S, Shima H, Narumi S, Meshinchi S, Olson TS.: Poor Outcome with Hematopoietic Stem Cell Transplantation for Bone Marrow Failure and MDS with Severe MIRAGE Syndrome Phenotype. Blood Adv 2 (2): 120-125,2018.

Babushok, DV, Stanley NL, Morrissette JJD, Lieberman DB, Olson TS, Chou ST, Hexner EO: Germline duplication of ATG2B and GSKIP genes is not required for the familial myeloid malignancy syndrome associated with the duplication of chromosome 14q32 Leukemia : 2018.

Babushok, DV, Nelson, EJ, Morrissette, JJD, Joshi, S, Palmer, MB, Frank, D, Cambor, CL, Hexner, EO: Myelofibrosis patients can develop extramedullary complications including renal amyloidosis and sclerosing hematopoietic tumor while otherwise meeting traditional measures of ruxolitinib response Leukemia & Lymphoma : 2018.

Peslak SA, Olson TS, Babushok DV.: Diagnosis and Treatment of Aplastic Anemia, Current Treatment Options in Oncology, Curr Treat Options Oncol 18 (12): 70,2017.

Babushok DV, Duke JL, Xie HM, Stanley N, Atienza J, Perdigones, N, Nicholas P, Ferriola D, Li Y, Huang H, Ye W, Morrissette J, Podsakoff G, Biegel JA, Chou S, Monos DS, Bessler M, Olson TS.: Somatic HLA Mutations Expose the Role of Class I-Mediated Autoimmunity in Aplastic Anemia and its Clonal Complications. Blood Adv 1 (22): 1900-1910,2017.

Reilly CR, Babushok DV, Martin K, Spivak JL, Streiff M, Bahirwani R, Mondschein J, Stein B, Moliterno A, Hexner EO.: Multicenter analysis of the use of transjugular intrahepatic portosystemic shunt for management of MPN-associated portal hypertension. Am J Hematol 92 (9): 909-914,2017.

View all publications

Academic Contact Info

Biomedical Research Building II/III, Room 808
421 Curie Boulevard
Philadelphia, PA 19104

Philadelphia, PA 19104
Phone: (215) 614-1847
Patient appointments: 800-789-7366 (PENN)