Description of Research Expertise:
The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.
We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the development of clonal hematopoiesis in bone marrow failure and aging.
Clonal hematopoiesis, bone marrow failure, aplastic anemia, PNH, malignant predisposition to MDS and leukemia
We are always looking for talented individuals who are passionate about science. There are opportunities to contribute at every level, and we welcome inquiries from undergraduate and graduate students, postdoctoral scientists, and medical students, residents, and fellows. Please contact Daria.Babushok at uphs.upenn.edu to discuss research opportunities.
Kathy Guo – Research Specialist
Natasha Stanley – Research Specialist
Taylor Linaburg – Medical Student
Babushok DV: A Brief, But Comprehensive, Guide to Clonal Evolution in Aplastic Anemia Hematology 2018 : 2018.
Aynardi J, Manur R, Hess PR, Chekol S, Morrissette JJD, Babushok D, Hexner E, Rogers HJ, Hsi ED, Margolskee E, Orazi A, Hasserjian R, Bagg A.: JAK2 V617F-positive acute myeloid leukaemia (AML): a comparison between de novo AML and secondary AML transformed from an underlying myeloproliferative neoplasm. A study from the Bone Marrow Pathology Group. Br J Haematol. : 2018.
Soderquist CR, Ewalt MD, Czuchlewski DR, Geyer JT, Rogers HJ, Hsi ED, Wang SA, Bueso-Ramos CE, Orazi A, Arber DA, Hexner EO, Babushok DV, Bagg A.: Myeloproliferative Neoplasms with Concurrent BCR-ABL1 Translocation and JAK2 V617F Mutation: a Multi-institutional Study from the Bone Marrow Pathology Group. Mod Pathol 31 (5): 690-704,2018.
Babushok D, Bessler M.: Aplastic Anemia and Pure Red Cell Aplasia. Chapter 18. In Anemia: Pathophysiology, Diagnosis and Management. Cambridge University Press : 2018.
Sarthy J, Zha J, Babushok D, Shenoy A, Fan J-M, Wertheim G, Himebach A, Munchel A, Taraseviciute A, Yang S, Shima H, Narumi S, Meshinchi S, Olson TS.: Poor Outcome with Hematopoietic Stem Cell Transplantation for Bone Marrow Failure and MDS with Severe MIRAGE Syndrome Phenotype. Blood Adv 2 (2): 120-125,2018.
Babushok, DV, Stanley NL, Morrissette JJD, Lieberman DB, Olson TS, Chou ST, Hexner EO: Germline duplication of ATG2B and GSKIP genes is not required for the familial myeloid malignancy syndrome associated with the duplication of chromosome 14q32 Leukemia : 2018.
Babushok, DV, Nelson, EJ, Morrissette, JJD, Joshi, S, Palmer, MB, Frank, D, Cambor, CL, Hexner, EO: Myelofibrosis patients can develop extramedullary complications including renal amyloidosis and sclerosing hematopoietic tumor while otherwise meeting traditional measures of ruxolitinib response Leukemia & Lymphoma : 2018.
Peslak SA, Olson TS, Babushok DV.: Diagnosis and Treatment of Aplastic Anemia, Current Treatment Options in Oncology, Curr Treat Options Oncol 18 (12): 70,2017.
Babushok DV, Duke JL, Xie HM, Stanley N, Atienza J, Perdigones, N, Nicholas P, Ferriola D, Li Y, Huang H, Ye W, Morrissette J, Podsakoff G, Biegel JA, Chou S, Monos DS, Bessler M, Olson TS.: Somatic HLA Mutations Expose the Role of Class I-Mediated Autoimmunity in Aplastic Anemia and its Clonal Complications. Blood Adv 1 (22): 1900-1910,2017.
Reilly CR, Babushok DV, Martin K, Spivak JL, Streiff M, Bahirwani R, Mondschein J, Stein B, Moliterno A, Hexner EO.: Multicenter analysis of the use of transjugular intrahepatic portosystemic shunt for management of MPN-associated portal hypertension. Am J Hematol 92 (9): 909-914,2017.
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