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Adults (18-65), Geriatrics (65+)
Adults (18-65), Geriatrics (65+)
Perelman Center for Advanced Medicine
West Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
RESEARCH INTERESTS:The Babushok Lab conducts basic and translational research to understand the fundamental mechanisms of how bone marrow can fail, how the failure of bone marrow can lead to pre-malignant genetic changes and myelodysplastic syndrome and leukemia, and what is the relationship between our immune system and the development of clonal hematopoiesis.We use state-of-the-art genome analysis, molecular biology and immunogenetic analyses, as well as in vitro and in vivo models to study the mechanisms of immune-mediated marrow failure and the factors that lead to the development of clonal hematopoiesis in bone marrow failure and aging.KEYWORDS:Clonal hematopoiesis, bone marrow failure, aplastic anemia, PNH, malignant predisposition to MDS and leukemiaROTATION PROJECTS:We are always looking for talented individuals who are passionate about science. There are opportunities to contribute at every level, and we welcome inquiries from undergraduate and graduate students, postdoctoral scientists, and medical students, residents, and fellows. Please contact Daria.Babushok at uphs.upenn.edu to discuss research opportunities.SEE BABUSHOK LAB WEBSITE LAB MEMBERS:Kathy Guo – Research SpecialistCaitlin Ritz - Research SpecialistNatasha Stanley – Research SpecialistMEDICAL STUDENT RESEARCHERS:Taylor Linaburg – Medical StudentTristan Lim - Medical StudentUNDERGRADUATE RESEARCHERS:Ben FrostJahnvi Patel
Sun L and Babushok DV: Secondary myelodysplastic syndrome and leukemia in acquired aplastic anemia and paroxysmal nocturnal hemoglobinuria10. Blood : 2020.
Sung PJ, Babushok DV: Born to RUNX1 Blood : 2020.
Ritz C, Meng W, Stanley NL, Baroja ML, Xu C, Yan P, Huang AC, Hausler R, Nicholas P, Fan JM, Lieberman D, Carreno BM, Luning Prak ET, Olson TS, Babushok DV.: Postvaccination graft dysfunction/aplastic anemia relapse with massive clonal expansion of autologous CD8+ lymphocytes. Blood Adv : 2020.
Babushok D: Eltrombopag: wielding a double-edged sword? Blood : 2019.
Linaburg T, Davis AR, Frey NV, Khawaja MR, Landsburg DJ, Schuster SJ, Svoboda J, Li Y, Borovskiy Y, Olson TS, Bagg A, Hexner EO, Babushok DV.: Hodgkin lymphoma patients have an increased incidence of idiopathic acquired aplastic anemia. PLoS One : 2019.
Oved JH, Stanley N, Babushok DV, Huang Y, Duke JL, Monos DS, Teachey DT, Olson TS.: Development of hemolytic paroxysmal nocturnal hemoglobinuria without graft loss following hematopoietic stem cell transplantation for acquired aplastic anemia. Pediatric Transplant : 2019.
Babushok DV, Hsu AP, Dokal I: Bone Marrow Failure Syndromes. Chapter 15 In Stiehm's Immune Deficiencies, 2nd edition : 2019.
Babushok DV: A Brief, But Comprehensive, Guide to Clonal Evolution in Aplastic Anemia Hematology 2018 : 2018.
Babushok DV: Expert commentary on “Severe aplastic anemia: allogeneic bone marrow transplantation as first-line treatment Blood Adv : 2018.
Ganetsky A, Han JH, Hughes ME, Babushok DV, Frey NV, Gill SI, Hexner EO, Loren AW, Luger SM, Mangan JK, Martin ME, Smith J, Freyer CW, Gilmar C, Schuster M, Stadtmauer EA, Porter DL.: Oral vancomycin prophylaxis is highly effective in preventing Clostridium difficile infection in allogeneic hematopoietic cell transplant recipients. Clin Infect Dis. : 2018.
Biomedical Research Building II/III, Room 808421 Curie BoulevardPhiladelphia, PA 19104
Patient appointments: 800-789-7366