Penn Medicine Provider
Daniel P. Kelly, MD
Sees patients age 18 and up

About me

  • Director, Cardiovascular Institute
  • Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
  • Professor of Medicine in Pediatrics

My Locations

Qualifications and experience

My research

Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension , Scientific Reports, 15(1): 2025


Doan K, Luongo TS, Ts’olo T, Lee WD, Frederick D, Mukherjee S, Adzika G, Perry C, Gaspar R, Walker N, Blair MC, Bye N, Davis J, Holman C, Chu Q, Wang L, Rabinowitz J, Kelly DP, Cappola TP, Margulies KB, Baur JA Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics , Nat Cardiovasc Res: 2024


Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice , CircRes: 2024


Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension , bioRxiv: 2024


Bailey LRJ, Bugg D, Reichardt IM, Ortac CD, Nagle A, Gunaje J, Martinson A, Johnson R, MacCoss MJ, Sakamoto T, Kelly DP, Regnier M, Davis JM MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states , Circulation: 2024


Williams AS, Crown SB, Lyons SP, Koves TR, Wilson RJ, Johnson JM, Slentz DH, Kelly DP, Grimsrud PA, Zhang GF, Muoio DM Ketone flux through BDH1 supports metabolic remodeling of skeletal and cardiac muscles in response to intermittent time-restricted feeding , Cell Metab: 2024


Kelly DP Replenishing the physician-scientist pipeline in the post-late bloomer era , J Clin Invest: 2024


Vite A, Matsuura TR, Bedi Jr KC, Flam EL, Arany, Z, Kelly DP, Margulies KB Functional impact of alternative metabolic substrates in failing human cardiomyocytes , JACC: BTS : 2024


Selvaraj S, He M, Thompson EJ, Hornik CP, Devore AD, Patel CB, Mentz RJ, Fudim M, Kwee LC, Taylor L, Milosovic S, Hurdle M, Cade WT, Ilkayeva O, Muehlbauer MJ, Newgard CB, Kelly DP, Zamani P, Margulies KB; Shah SH Metabolic and pharmacokinetic profiling of an exogenous ketone ester by background SGLT2 inhibitor therapy in heart failure with reduced ejection: A Phase I clinical trial , JACC: BTS: 2024


Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for heart failure with reduced ejection fraction in mice , bioRxiv: 2024