Daniel P. Kelly, MD
Sees patients age 18 and up
Penn Medicine Provider

About me

  • Director, Cardiovascular Institute
  • Willard and Rhoda Ware Professor of Diabetes and Metabolic Diseases
  • Professor of Medicine in Pediatrics

Insurance accepted

My Locations

Qualifications and experience

Treatments and Conditions

My research

166., Naeem F, Leone TC, Petucci C, Shoffler C, Kodihalli RC, Hidalgo T, Tow-Keogh C, Mancuso J, Tzameli I, Bennett D, Groarke JD, Roth Flach RJ, Rader DJ, and Kelly DP Targeted Quantitative Plasma Metabolomics Identifies Metabolite Signatures that Distinguish Heart Failure with Reduced and Preserved Ejection Fraction , ESC Hear Failure : 2025


Selvaraj S, He M, Thompson EJ, Hornik CP, Devore AD, Patel CB, Mentz RJ, Fudim M, Kwee LC, Taylor L, Milosovic S, Hurdle M, Cade WT, Ilkayeva O, Muehlbauer MJ, Newgard CB, Kelly DP, Zamani P, Margulies KB; Shah SH Metabolic and pharmacokinetic profiling of an exogenous ketone ester by background SGLT2 inhibitor therapy in heart failure with reduced ejection: A Phase I clinical trial , JACC: BTS: 2025


164., Selvaraj S, Karaj A, Chirinos J, Denney N, Grosso G, Fernando M, Chambers K, Demastus C, Reddy R, Langham M, Kumar D, Maynard H, Pourmussa B, Prenner S, Cohen J, Ischiropoulos H, Rickels M, Poole D, Church D, Wolfe R, Kelly DP, Putt M, Margulies K, Zamani P Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction , JACC Heart Fail : 2025


Berger JH, Shi Y, Matsuura TR, Batmanov K, Chen X, Tam K, Marshall M, Kue R, Patel J, Taing R, Callaway R, Griffin J, Kovacs A, Shanthappa DH, Miller R, Zhang BB, Roth Flach RJ, Kelly DP Two-hit mouse model of heart failure with preserved ejection fraction combining diet-induced obesity and renin-mediated hypertension , Scientific Reports, 15(1): 2025


Pruzinsky E, Batmanov K, Medeiros DM, Sulon SM, Sakamoto T, Leone TC, Khurana T, Kelly DP A Role for the Transcriptional Coregulator RIP140 in the Control of Muscle Endurance Fitness , JCI Insight: 2025


Doan KV, Gaspar RB, Lee WD, Oschmann AM, Ts’olo TT, Frederick DW, Velِázquez Aponte RA, Adzika GK, McGaunn JP, Bye N, Mukherjee S, Davis JG, Holman CD, Chu Q, Garcia A, Ranamurthy R, Cheng L, Migaud ME, Rabinowitz JD, Kelly DP, Baur JA Low cardiac NAD+ causes hypertrophy through a ketone-sensitive beta-adrenergic signaling pathway , Submitted: 2025


Gorgodze N, Matsuura TR, Nisini N, Berretta R, Recchia A, Werlen A, Wang T, Houser S, Kelly DP, Recchia FA The Medium Chain Fatty Acid Octanoate is a Beneficial Fuel for the Failing Heart , Submitted: 2025


Doan K, Luongo TS, Ts’olo T, Lee WD, Frederick D, Mukherjee S, Adzika G, Perry C, Gaspar R, Walker N, Blair MC, Bye N, Davis J, Holman C, Chu Q, Wang L, Rabinowitz J, Kelly DP, Cappola TP, Margulies KB, Baur JA Cardiac NAD+ depletion in mice promotes hypertrophic cardiomyopathy and arrhythmias prior to impaired bioenergetics , Nat Cardiovasc Res: 2024


Berger J, Matsuura TR, Bowman CE, Taing R, Patel J, Lai L, Leone TC, Reagan JD, Haldar SM, Arany Z, Kelly DP Sodium-glucose co-transporter 2 Inhibitors Act Independently of SGLT2 to Confer Benefit for Heart Failure with Reduced Ejection Fraction in Mice , CircRes: 2024


Bailey LRJ, Bugg D, Reichardt IM, Ortac CD, Nagle A, Gunaje J, Martinson A, Johnson R, MacCoss MJ, Sakamoto T, Kelly DP, Regnier M, Davis JM MBNL1 regulates programmed postnatal switching between regenerative and differentiated cardiac states , Circulation: 2024