Clyde E. Markowitz, MD

Neurology
Accepting new patients
Sees patients age 18 and up
Penn Neuroscience Center - Neurology
Penn Medicine Provider

About me

  • Director, Multiple Sclerosis Center at Penn
  • Associate Professor of Neurology at the Hospital of the University of Pennsylvania

My education and training

  • Medical School: Columbia University
  • Residency: NewYork–Presbyterian Hospital
  • Fellowship: NewYork-Presbyterian/Columbia University Medical Center

Spoken languages

English
English

Reviews

Average Rating

847 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
July 2026
he is a knowledgeable neurologist.
Anonymous
July 2026
amazing experience
Anonymous
July 2026
very caring and great bedside manner.
Anonymous
July 2026
i trust dr markowitz opinion

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Markowitz is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Miller TM, Cudkowicz ME, Shaw PJ, Genge A, Sobue G, Bucelli RC, Chiò A, Van Damme P, Ludolph AC, Glass JD, Andrews JA, Babu S, Benatar M, McDermott CJ, Salachas F, Bruneteau G, Al-Chalabi A, Amorin M, Nestorov I, Graham D, Lin L, Sun P, McNeill M, Malek S, Inra J, Garafalo S, Fradette S; VALOR and OLE Working Group. Long-Term Tofersen in SOD1 Amyotrophic Lateral Sclerosis , JAMA Neurol, 83: 2026,115-125


Simon Thebault, Samantha Soldan, Gautier Breville, Luana Yamashita, Elia Afanasiev, jo Anne stratton, Christopher Perrone, Clyde Markowitz, Paul Lieberman, Amit Bar-Or "Immunophenotypic characterisation of EBV-infected B cells in MS blood and CSF using PrimeFlow" , ECTRIMS 2025, Barcelona , Spain , 31(3): 2025


Naydovich LR, Orthmann-Murphy JL, Markowitz CE. Beyond relapses: How BTK inhibitors are shaping the future of progressive MS treatment , Neurotherapeutics, 22 (4): 2025


Cooper EC, Schindler MK, Bar-Or A, Brandstadter RB, Calkins ME, Gur R, Jacobs DA, Markowitz C, Moore T, Naydovich LR, Perrone CM, Ruparel K, Spangler BC, Troyan S, Shinohara RT, Satterthwaite TD, Baller EB. Investigating mood and cognition in people with multiple sclerosis: a prospective cross-sectional study protocol , BMJ Open, 15: 2025,e094733


Martin ML, Robert-Fitzgerald T, Schindler MK, Perrone C, Schultz G, Lynch S, Mirkovic N, Thomas S, Elahi A, Reid D, Moore TM, Baller EB, Satterthwaite TD, Cieslak M, Covitz S, Adebimpe A, Manning A, Markowitz CE, Detre JA, Bar-Or A, Kakara M, Shinohara RT. Impact of insurance status on MRI phenotypes in MS , Mult Scler Relat Disord: 2024


Baller EB, Sweeney EM, Cieslak M, Robert-Fitzgerald T, Covitz SC, Martin ML, Schindler MK, Bar-Or A, Elahi A, Larsen BS, Manning AR, Markowitz CE, Perrone CM, Rautman V, Seitz MM, Detre JA, Fox MD, Shinohara RT, Satterthwaite TD. Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis , Biol Psychiatry, 95: 2024,1072-1080


Coyle PK, Freedman MS, Cohen BA, Cree BAC, Markowitz CE. Sphingosine 1-phosphate receptor modulators in multiple sclerosis treatment: A practical review , Ann Clin Transl Neurol, 11(4): 2024,842-855


Gandelman S, Lenzi KA, Markowitz C, Berger JR. A Proposed Approach to Screening and Surveillance Labs for Patients With Multiple Sclerosis on Anti-CD20 Therapy , Neurol Clin Pract, 14(1): 2024


Clark KA, O'Donnell CM, Elliott MA, Tauhid S, Dewey BE, Chu R, Khalil S, Nair G, Sati P, DuVal A, Pellegrini N, Bar-Or A, Markowitz C, Schindler MK, Zurawski J, Calabresi PA, Reich DS, Bakshi R, Shinohara RT; NAIMS Cooperative. Intersite brain MRI volumetric biases persist even in a harmonized multisubject study of multiple sclerosis , J Neuroimaging, 33(6): 2023,941–952


Thebault S, Gandelman S, Lane C, Kim EJ, Pileggi C, Zuroff L, Yamashita LD, Schindler MK, Chiu C, Wilson MR, Berger JR, Markowitz C, Bar-Or A, Fuller R, Brandstadter R, Pruitt AA, Jacobs DA. Severe Neuroinvasive West Nile Virus in Association With Anti-CD20 Monotherapy for Multiple Sclerosis , Neurol Neuroimmunol Neuroinflamm, 10: 2023,e200154