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Clyde E. Markowitz, MD

Clyde E. Markowitz, MD Physician

Director, Multiple Sclerosis Center at Penn
Associate Professor of Neurology at the Hospital of the University of Pennsylvania

Dr. Markowitz is a Penn Medicine employed physician.

Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1995

Clinical Expertise:

  • Multiple Sclerosis (MS)
  • Neuroimmunology

Practice Locations and Appointments

  • Penn Neurology

    Penn Neuroscience Center Perelman Center for Advanced Medicine, South Pavilion, 2nd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-PENN (7366)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Columbia University
Residency: NewYork-Presbyterian/Columbia University Medical Center
Fellowship: NewYork-Presbyterian/Columbia University Medical Center


American Academy of Neurology, National American Academy of Neurology, National Bayer Healthcare, International Biogen-Idec, International BioMS, International Bristol Meyers Squib, International EMD Serono, International Genentech, International International Multiple Sclerosis Forum, International Multiple Sclerosis Cooperative Research Group (MS-CORE), National National Multiple Sclerosis Society, Delaware Valley Chapter, Local Novartis, International Penn Neuro Care- MS Section, Local Pfizer, International Teva Neuroscience, International Wyeth, International

Hospital Affiliation

Dr. Markowitz is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Selected Publications:

Jose Torres, Amy Pruitt, Laura Balcer, Steven Galetta, Clyde Markowitz, Nabila Dahodwala: Analysis of the treatment of neuromyelitis optica Journal of the Neurological Sciences 351 (1): 2015.

Salim Chahin, Deborah Miller, Reiko E. Sakai, James A. Wilson, Teresa Frohman, Clyde Markowitz, Dina Jacobs, Ari Green, Peter A. Calabresi, Elliot M. Frohman, Steven L. Galetta, Laura J. Balcer: Relation of quantitative Visual and neurologic outcomes to fatigue in multiple sclerosis Multiple Sclerosis and Related Disorders 4 (4): 2015.

Edward Fox, Barbara Green, Clyde Markowitz, Ronald Murray, Andrew D Goodman, Stephen J Glenski, Pippa Loupe, Jo Nita Cogburn: The effect of scheduled antibody testing on treatment patterns in interferon-treated patients with multiple sclerosis BMC Neurology 14 (1): 2014.

Patricia K Coyle, Bruce A Cohen, Thomas Leist, Clyde Markowitz, Merrikay Oleen-Burkey, Marc Schwartz, Mark J Tullman, Howard Zwibel: Therapy optimization in multiple sclerosis: a prospective observational study of therapy compliance and outcomes BMC Neurology 14 (1): 2014.

Miller Aaron E, Cohen Bruce A, Krieger Stephen C, Markowitz Clyde E, Mattson David H, Tselentis Helen N: Constructing an adaptive care model for the management of disease-related symptoms throughout the course of multiple sclerosis--performance improvement CME. Multiple sclerosis (Houndmills, Basingstoke, England) : 2013.

Oh Se-Hong, Bilello Michel, Schindler Matthew, Markowitz Clyde E, Detre John A, Lee Jongho: Direct visualization of short transverse relaxation time component (ViSTa). NeuroImage 83C : 485-492,2013.

Fox Edward, Wynn Daniel, Cohan Stanley, Rill Donna, McGuire Dawn, Markowitz Clyde: A randomized clinical trial of autologous T-cell therapy in multiple sclerosis: subset analysis and implications for trial design. Multiple sclerosis (Houndmills, Basingstoke, England) 18 (6): 843-52,2012.

Dhib-Jalbut S, Markowitz C, Patel P, Boateng F, Rametta M: The Combined Effect of Nursing Support and Adverse Event Mitigation on Adherence to Interferon Beta-1b Therapy in Early Multiple Sclerosis International Journal of MS Care 14 (4): 198-208,2012.

Schelleman Hedi, Pollard John R, Newcomb Craig, Markowitz Clyde E, Bilker Warren B, Leonard Mary B, Hennessy Sean: Exposure to CYP3A4-inducing and CYP3A4-non-inducing antiepileptic agents and the risk of fractures. Pharmacoepidemiology and drug safety 20 (6): 619-25,2011.

Keltner JL, Cello KE, Balcer LJ, Calabresi PA, Markowitz CE, Werner JS: Stratus OCT Quality Control in Two Multi-Centre Multiple Sclerosis Clinical Trials Neuro-Ophthalmology 35 (2): 57-64,2011.

Academic Contact Info

Hospital of the University of Pennsylvania
3 West Gates Building
3400 Spruce Street

Philadelphia, PA 19104
Phone: (215) 662-4521
Fax: (215) 349-5579
Patient appointments: 800-789-PENN (7366)

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