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Christos Davatzikos, PhD

Christos Davatzikos, PhD Researcher

Wallace T. Miller, Sr. Professor

Dr. Davatzikos is employed by Penn Medicine.

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ACRIN Head Neck and Neuro Committee, National Biodata Management and Analysis Study Section, National National Institute of Mental Health (NIMH), National NIH, National NIH, National NIH, National Quantitative Imaging Network, National

Hospital Affiliation

Dr. Davatzikos is employed by Penn Medicine.


Description of Research Expertise:

Biomedical Image Computing, image analysis, neuroimaging, machine learning

Selected Publications:

Rathore S, Habes M, Iftikhar MA, Shacklett A, Davatzikos C: "A review on neuroimaging-based classification studies and associated feature extraction methods for Alzheimer's disease and its prodromal stages" NeuroImage 155 : 530-548,2017.

Sotiras A, Toledo JB, Gur RE, Gur RC, Satterthwaite TD, Davatzikos C: "Patterns of coordinated cortical remodeling during adolescence and their associations with functional specialization and evolutionary expansion" Proceedings of the National Academy of Sciences 114 (13): 3527-3532,2017.

Akbari H, Macyszyn L, Da X, Bilello M, Wolf RL, Martinez-Lage M, Biros G, Alonso-Basanta M, OʼRourke DM, Davatzikos C: "Imaging Surrogates of Infiltration Obtained Via Multiparametric Imaging Pattern Analysis Predict Subsequent Location of Recurrence of Glioblastoma" Neurosurgery 78 (4): 572-80,2016.

Davatzikos C: "Computational neuroanatomy using brain deformations: From brain parcellation to multivariate pattern analysis and machine learning" Med Image Anal 33 : 149-154,2016.

Habes M, Janowitz D, Erus G, Toledo JB, Resnick SM, Doshi J, Van der Auwera S, Wittfeld K, Hegenscheid K, Hosten N, Biffar R, Homuth G, Völzke H, Grabe HJ, Hoffmann W, Davatzikos C: "Advanced brain aging: relationship with epidemiologic and genetic risk factors, and overlap with Alzheimer disease atrophy patterns" Translational Psychiatry 6 (4): e775,2016.

Macyszyn, L, Akbari, H, Pisapia, JM, Da, X, Attiah, M, Pigrish V, Bi Y, Pal S, Davuluri RV, Roccograndi L, Dahmane N, Martinez-Lage M, Biros G, Wolf RL, Bilello M, O'Rourke DM, Davatzikos, C: "Imaging patterns predict patient survival and molecular subtype in glioblastoma via machine learning techniques" Neuro Oncology 18 (3): 417-25,2016.

Eavani H, Satterthwaite TD, Filipovych R, Gur RE, Gur RC, Davatzikos C: "Identifying Sparse Connectivity Patterns in the brain using resting-state fMRI" NeuroImage 105 : 286-99,2015.

Erus G, Battapady H, Satterthwaite TD, Hakonarson H, Gur RE, Davatzikos C, Gur RC: "Imaging Patterns of Brain Development and their Relationship to Cognition" Cereb Cortex 25 (6): 1676-84,2015.

Williamson JD, Launer LJ, Bryan RN, Coker LH, Lazar RM, Gerstein HC, Murray AM, Sullivan MD, Horowitz KR, Ding J, Marcovina S, Lovato L, Lovato J, Margolis KL, Davatzikos C, Barzilay J, Ginsberg HN, Linz PE, Miller ME, Action to Control Cardiovascular Risk in Diabetes Memory in Diabetes Investigators: "Cognitive function and brain structure in persons with type 2 diabetes mellitus after intensive lowering of blood pressure and lipid levels: a randomized clinical trial" JAMA Intern. Med 174 (3): 2014.

Gaonkar, Bilwaj, and Christos Davatzikos: "Analytic estimation of statistical significance maps for support vector machine based multi-variate image analysis and classification." NeuroImage 78 : 270-283,2013.

Sotiras, A.; Davatzikos, C.; Paragios, N.: "Deformable Medical Image Registration: A Survey" IEEE Transactions on Medical Imaging 32 (7): 1153-1190,2013.

Ira Driscoll, Christos Davatzikos, Yang An, Xiaoying Wu, Dinggang Shen, Michael Kraut, Susan M. Resnick: Longitudinal pattern of regional brain volume change differentiates normal aging from MCI Neurology 72 (22): 1906-1913,2009.

Nikolaos Koutsouleris, Eva M. Meisenzahl, Christos Davatzikos, Ronald Bottlender, Thomas Frodl, Johanna Scheuerecker, BA; Gisela Schmitt, Thomas Zetzsche, Petra Decker, Maximilian Reiser, Hans-Jürgen Möller, Christian Gaser: Use of Neuroanatomical Pattern Classification to Identify Subjects in At-Risk Mental States of Psychosis and Predict Disease Transition Archives of General Psychiatry 66 (7): 700-712,2009.

Davatzikos, Christos; Xu, Feng; An, Yang; Fan, Yong; Resnick, Susan: "Longitudinal progression of Alzheimer’s-like patterns of atrophy in normal older adults: the SPARE-AD index" Brain 132 (8): 2023-2035,2009.

S. M. Resnick, M. A. Espeland, S. A. Jaramillo, MS, C. Hirsch, M. L. Stefanick, A. M. Murray, MSc, J. Ockene, C. Davatzikos, For the Women’s Health Initiative Memory Study: "Postmenopausal hormone therapy and regional brain volumes. The WHIMS-MRI Study" Neurology 72 (2): 135-142,2009.

Evangelia I Zacharaki, Cosmina S Hogea, Dinggang Shen, George Biros, Christos Davatzikos: Non-diffeomorphic registration of brain tumor images by simulating tissue loss and tumor growth NeuroImage 46 (3): 762-774,2009.

Cosmina Hogea, Christos Davatzikos, and George Biros: Brain-tumor interaction biophysical models for medical image registration SIAM J. Sci. Comput. 30 (6): 30550-3072,2008.

E. I. Zacharaki, D. Shen, S.-K. Lee, and C. Davatzikos: "ORBIT: A Multiresolution Framework for Deformable Registration of Brain Tumor Images" IEEE Transactions on Medical Imaging 27 (8): 1003-1017,2008.

Ragini Verma, Evangelia I. Zacharaki, Yangming Ou, Hongmin Cai, Sanjeev Chawla, Seung-Koo Lee, Elias R. Melhem, Ronald Wolf and Christos Davatzikos: "Multiparametric Tissue Characterization of Brain Neoplasms and Their Recurrence Using Pattern Classification of MR Images" Academic Radiology 15 (8): 966-977,2008.

C. S. Hogea, G. Biros, and C. Davatzikos: "An image-driven parameter estimation problem for a reaction-diffusion glioma growth model with mass effects" Journal of Mathematical Biology 56 (6): 793-825,2008.

Susan M. Resnick, Mark A. Espeland, Sarah A. Jaramillo, Calvin Hirsch, Marcia L. Stefanick, Anne M. Murray, Judith Ockene, Christos Davatzikos: "Effects off postmenopausal hormone therapy on regional brain volumes in older women: The women's health initiative magnetic resonance imaging study (WHIMS-MRI)" Neurology 70 (11): A96-A96,2008.

Christos Davatzikos, Susan M. Resnick, Xiaoying Wu, Paraskevi Parmpi, Christopher M. Clark: "Individual patient diagnosis of AD and FTD via high-dimensional pattern classification of MRI" Neuroimage 41 (4): 1220-1227,2008 (Epub 8 April 2008).

Yong Fan, Susan M. Resnick, Xiaoying Wu and Christos Davatzikos: "Structural and functional biomarkers of prodromal Alzheimer's disease: A high-dimensional pattern classification study" Neuroimage (NeuroImage: Anatomy and Physiology Editors Choice Award 2008) 41 (2): 277-285,2008.

Christos Davatzikos, Yong Fan, Xiaoying Wu, Dinggang Shen, Susan M. Resnick: "Detection of prodromal Alzheimer's disease via pattern classification of magnetic resonance imaging" Neurobiology of Aging 29 (4): 514-523,2008.

Brian Caffo, Sining Chen, Walter Stewart, Karen Bolla, David Yousem, Christos Davatzikos, Brian S. Schwartz: "Are brain volumes based on magnetic resonance imaging mediators of the associations of cumulative lead dose with cognitive function?" American Journal of Epidemiology 167 (4): 429-437,2008.

Yong Fan, Raquel E. Gur, Ruben C. Gur, Dinggang Shen, Monica E. Calkins, Christos Davatzikos: "Unaffected Family Members and Schizophrenia Patients Share Brain Structure Patterns: a High-Dimensional Pattern Classification Study Biological Psychiatry" Biological Psychiatry 63 (1): 118-124,2008.

M. K. Belmonte, J. C. Mazziotta, N. J. Minshew, A. C. Evans, E. Courchesne, S. R. Dager, S. Y. Bookheimer, E. H. Aylward, D. G. Amaral, R. M. Cantor, D. C. Chugani, A. M. Dale, C. Davatzikos, G. Gerig, M. R. Herbert, J. E. Lainhart, D. G. Murphy, J. Piven, A. L. Reiss, R. T. Schultz, T. A. Zeffiro, S. Levi-Pearl, C. Lajonchere, and S. A. Colamarino: "Offering to Share: How to Put Heads Together in Autism Neuroimaging" Journal of Autism and Developmental Disorders 38 (1): 2-13,2008.

Academic Contact Info

Department of Radiology
University of Pennsylvania School of Medicine
Richards Building, 7th Floor
3700 Hamilton Walk

Philadelphia, PA 19104