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Christopher D. Watt, MD, PhD

Christopher D. Watt, MD, PhD Physician

Associate Director, Molecular Pathology Laboratory Assistant Professor of Clinical Pathology and Laboratory Medicine

Dr. Watt is employed by Penn Medicine.

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Clinical Specialties


  • Pathology and Laboratory Medicine

Programs & Centers:

  • Precision and Computational Diagnostic Services

Board Certification:

  • Pathology - Clinical Pathology, 2008
  • Pathology - Molecular Genetic Pathology, 2009

Description of Clinical Expertise

Molecular Pathology

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Medical Association, Member, National American Society for Clinical Pathology, Fellow Member, International Association for Molecular Pathology, Associate Member, International College of American Pathologists, Fellow Member, International

Hospital Affiliation

Dr. Watt is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Selected Publications:

McMahon CM, Canaani J, Rea B, Sargent RL, Morrissette JJD, Lieberman DB, Watt CD, Schwartz GW, Faryabi RB, Ferng TT, Shah NP, Smith CC, Caroll M, and Perl AE: Mechanisms of acquired resistance to Gilteritinib therapy in relapsed and refractory FLT3-mutated acute myeloid leukemia. Blood 130 (s1): 295,2017.

Hatem J, Schrank-Hacker AM, Watt CD, Morrissette JJ, Rubin AI, Kim EJ, Nasta SD, Wasik MA, Bogusz AM.: Marginal zone lymphoma-derived interfollicular diffuse large B-cell lymphoma harboring 20q12 chromosomal deletion and missense mutation of BIRC3 gene: a case report. Diagnostic Pathology 11 : 137,2016.

Surrey LF, Smith JR, Lubin D, Van Deerlin V, Watt CD: Analytic Approach for Complete and Mixed Engraftment Analysis using Commercial Software. The Journal of Molecular Diagnostics 18 (6): 1030,2016.

Li Y, Alby K, Watt CD, Roth JJ: Integration of rapid molecular testing for influenza and RSV into existing diagnostic workflow. The Journal of Molecular Diagnostics 18 (6): 979,2016.

Press RD, Watt CD, Cai L, Van Deerlin VM, Roth JJ, Gentile C, Loren A, and Eickelberg G: BCR-ABL1 molecular responses at 12-18 months predict long-term event-free survival in patients with tyrosine kinase inhibitor (TKI)-treated chronic myelogenous leukemia (CML). The Journal of Molecular Diagnostics 18 (6): 964,2016.

Roth JJ, Windon AL, Strubinger J, Carlin A, Gentile C, Watt CD, McGrath CM, Van Deerlin VM: Improvements in workflow after verification and implementation of the cobas® HPV Test. The Journal of Molecular Diagnostics 18 (6): 970,2016.

Nybakken G, Canaani J, Darshan R, Morrissette J, Watt CD, Shah N, Smith C, Bagg A, Carroll M, and Perl A: Quizartinib elicits differential responses that correlate with karyotype and genotype of the leukemic clone. Leukemia 30 (6): 1422-5,2016.

Canaani J, Rea B, Sargent R, Morrissette J, Lieberman D, Watt CD, Carroll M, Perl A: Differentiation response to gilteritinib (ASP2215) in relapsed/refractory FLT3 mutated acute myeloid leukemia patients is associated with co-mutations in NPM1 and DNMT3A. Haematologica, 2016 European Hematology Association Annual Congress 101 (S1): 2016.

Hiemenz MC, Kadauke S, Lieberman DB, Roth DB, Zhao J, Watt CD, Daber RD, Morrissette JJ: Building a robust tumor profiling program: Synergy between next-generation sequencing and targeted single-gene testing. PLoS One 11 (4): e0152851,2016.

Cambor C, Roth D, Loundas C, Heuer M, Watt C, Montone K, Sesok-Pizzini D: Development of a dynamic leadership curriculum to enhance residency education in pathology and laboratory medicine. Modern Pathology 29 (S2): 2016.

Academic Contact Info

Department of Pathology and Laboratory Medicine
Hospital of the University of Pennsylvania
3400 Spruce Street

Philadelphia, PA 19104
Patient appointments: 800-789-7366 (PENN)