Description of Research Expertise

Dr. Aggarwal is the Leslye Heisler Assistant Professor of Medicine in the Hematology-Oncology Division at the University of Pennsylvania’s Perelman School of Medicine. She is an active member of the Abramson Cancer Center (ACC) where she serves as Physician Leader for the clinical research program for Airways Malignancies.

Dr. Aggarwal specializes in the management of patients with lung and head and neck cancer, with a specific and clinical research focus on the development of novel immunotherapeutic approaches, and the discovery and application of biomarkers to guide therapy and monitor treatment. She serves as the local and national principle investigator for multiple clinical trials focusing on the development of “targeted” immunotherapeutic approaches including cellular therapy and CAR-T for solid tumors. Dr. Aggarwal has led the development of a DNA plasmid based HPV specific immunotherapy for HPV associated head and neck cancers. She is actively involved in evaluating the role of plasma-based NGS in management of patients with metastatic lung cancer.

She has extensive experience in the planning, design and execution of clinical trials, is an active member of ECOG, and has served as a national sub-study chair for SWOG-NCI’s LUNG-MAP. She has served on the Annual Meeting Scientific Program Committee of American Society of Clinical Oncology (ASCO), ASCO Education Committee, NCI- Head and Neck Metastatic Task Force Steering Committee and ACC’s Data Safety and Monitoring Committee. Dr. Aggarwal’s ultimate goal as a clinical and translational investigator is to perform patient-centered, scientifically relevant novel immunotherapy clinical trials that will make a tangible impact and advance our understanding of immunotherapy in patients with Lung and Head and Neck Cancer.

Selected Publications

Lee SH, Kao GD, Feigenberg SJ, Dorsey JF, Frick MA, Jean-Baptiste S, Uche CZ, Cengel KA, Levin WP, Berman AT, Aggarwal C, Fan Y, Xiao Y: Multi-block Discriminant Analysis of Integrative 18 F-FDG-PET/CT Radiomics for Predicting Circulating Tumor Cells in Early Stage Non-small Cell Lung Cancer Treated with Stereotactic Body Radiation Therapy Int J Radiat Oncol Biol Phys. 21 (1:S0360-3016(21)00208-X): 2021.

Aggarwal C, Thompson JC, Carpenter EL.: Plasma Tumor Mutation Burden and Response to Pembrolizumab-Response. Clinical Cancer Research 1;27(5):1581 : doi: 10.1158/1078-0432,2021.

Jiao Z, Li H, Xiao Y, Aggarwal C, Galperin-Aizenberg M, Pryma D, Simone CB 2nd, Feigenberg SJ, Kao GD, Fan Y.: Integration of risk survival measures estimated from pre- and post-treatment CT scans improves stratification of early stage non-small cell lung cancer patients treated with stereotactic body radiation therapy Int J Radiat Oncol Biol Phys 14;S0360-3016(20)34660-5. : Online ahead of print,2021.

Sun L, Aggarwal C: Immunotherapy for Lung Cancer-Improving Outcomes in Patients With Locally Advanced Non-Small Cell Lung Cancer With Immunotherapy Cancer Journal (6):548-554 : doi: 10.1097/PPO.0000000000000485,2020.

Carey RM, Shimunov D, Weinstein GS, Cannady SB, Lukens JN, Lin A, Swisher-McClure S, Bauml JM, Aggarwal C, Cohen RB, Newman JG, Chalian AA, Rassekh CH, Basu D, O'Malley BW Jr, Rajasekaran K, Brody RM.: Increased rate of recurrence and high rate of salvage in patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma with adverse features treated with primary surgery without recommended adjuvant therapy Head Neck (doi: 10.1002/hed.26578): Online ahead of print,2020.

Jelinek M, Aggarwal C: Adjuvant Osimertinib: A New Standard of Care Oncologist (doi: 10.1002/onco.13634): Online ahead of print,2020.

Marmarelis ME, Chiarle R, Ambrogio C, Aggarwal C: A LIBRETTO to orchestrate targeted therapy Nature Cancer 1 (11): 1038-1040,2020.

Parhar HS, Shimunov D, Newman JG, Cannady SB, Rajasekaran K, O' Malley BW Jr, Chalian AA, Rassekh CH, Cohen RB, Lin A, Lukens J, Swisher-McClure S, Bauml J, Aggarwal C, Weinstein GS, Brody RM: Oncologic Outcomes Following Transoral Robotic Surgery for Human Papillomavirus-Associated Oropharyngeal Carcinoma in Older Patients JAMA Otolaryngol Head Neck Surg : doi: 10.1001/jamaoto.2020.3787. Online ahead of print,2020.

Sun L, Davis CW, Hwang WT, Jeffries S, Sulyok LF, Marmarelis ME, Singh AP, Berman AT, Feigenberg SJ, Levin W, Ciunci CA, Bauml JM, Cohen RB, Langer CJ, Aggarwal C: Outcomes in patients with non-small cell lung cancer with brain metastases treated with pembrolizumab-based therapy Clinical Lung Cancer 11 : S1525-7304(20)30327-2,2020.

Aggarwal C, Rolfo CD, Oxnard GR, Gray JE, Sholl LM, Gandara DR: Strategies for the successful implementation of plasma-based NSCLC genotyping in clinical practice Nat Rev Clin Oncol : 2020.

Academic Contact Information

Perelman Center for Advanced Medicine
10-137, South Pavilion
3400 Civic Center Boulevard
Philadelphia, PA 19104
Phone: 215-662-6318
Patient appointments: 800-789-7366