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Charles S. Abrams, MD

Charles S. Abrams, MD Physician

Director, PENN-CHOP Blood Center for Patient Care & Discovery Vice-Chair for Research and Chief Scientific Officer, Department of Medicine Professor of Medicine in Pathology and Laboratory Medicine Francis C. Wood Professor

Dr. Abrams is employed by Penn Medicine.

About Dr. Charles S. Abrams

Recognized by America's Top Doctors, 2007, 2008, 2010 - 2018

Recognized by Best Doctors in America 2005 - 2018

Recognized annually in Philadelphia magazine's Top Docs issue from 2005 through 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Hematology

Programs & Centers:

Board Certification:

  • Hematology, 1990
  • Internal Medicine, 1987
  • Medical Oncology, 1989

Clinical Expertise:

  • Anemia
  • Anemia and Bone Marrow Disorders
  • Anemia of Chronic Disease
  • Anemia of Pregnancy
  • Anticoagulation
  • Antiphospholipid Syndrome
  • Antithrombin Deficiency
  • Aplastic Anemia
  • Autoimmune Hemolytic Anemia
  • B12 Deficiency Anemia
  • Blood Clot
  • Blood Clotting Disorders (Blood Coagulation)
  • Blood Disorders
  • Blood Platelet Disorders
  • Catastrophic Antiphospholipid Syndrome
  • Coagulation Disorders
  • Cold Agglutinin Disease
  • Cooley's Anemia
  • Cryoglobulinemia
  • Deep Thrombophlebitis
  • Deep Vein Thrombosis
  • Eosinophilic Granuloma
  • Essential Thrombocytosis
  • Factor Eight Disorder
  • Factor Nine Deficiency
  • Factor V Leiden
  • Familial Aplastic Anemia
  • Folic Acid Deficiency
  • Glucose-6-Phosphate Dehydrogenase Deficiency
  • HELLP Syndrome
  • Hemochromatosis
  • Hemoglobinopathies
  • Hemolytic Anemia
  • Hemolytic Uremic Syndrome
  • Hemophilia
  • Heparin-Induced Thrombocytopenia
  • Hereditary Spherocytosis
  • Histiocytosis
  • Hypercoagulable State
  • Hypogammaglobulinemia
  • Idiopathic Thrombocytopenic Purpura
  • Iron Deficiency Anemia
  • Iron Metabolism Disorders
  • Leukocytosis
  • Leukopenia
  • Lupus Anticoagulant
  • Maternal Anticoagulation
  • Maternal Hematologic Disorders
  • Maternal Thrombophilia
  • Monoclonal Gammopathy of Undetermined Significance
  • Myeloproliferative Neoplasms (MPN)
  • Neutropenia
  • Pancytopenia
  • Paroxysmal Nocturnal Hemoglobinuria
  • Partial Thromboplastin Time Blood Test
  • Pernicious Anemia
  • Petechiae
  • POEMS Syndrome
  • Polycythemia
  • Postthrombotic Syndrome
  • Primary Systemic Amyloidosis
  • Protein C Deficiency
  • Protein S Deficiency
  • Prothrombin Gene Mutation
  • Pure Red Cell Aplasia
  • Purpura
  • Recurrent Thrombosis
  • Red Blood Cell Disorders
  • Secondary Polycythemia
  • Splenic Sequestration
  • Splenomegaly
  • Thalassemias
  • Thrombocytopenia
  • Thrombocytosis
  • Thrombophilia
  • Thrombotic Disorders
  • Thrombotic Thrombocytopenic Purpura
  • Venous-Occlusive Crisis
  • Von Willebrand Disease
  • White Blood Cell Disorders
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Yale University
Residency: Temple University Hospital
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American Board of Internal Medicine, National American Society for Clinical Investigation, National American Society of Hematology, National Association of American Physicians, National International Society of Thrombosis and Haemostasis, International Interurban Clinical Club, National National Academy of Medicine, National

Hospital Affiliation

Dr. Abrams is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Research Interests

Phospholipid signaling in platelet and T-cells.

Key words: Pleckstrin, PH domains, cytoskeleton.

Description of Research

Inappropriate platelet activation contributes to vascular diseases including stroke and myocardial ischemia. Our laboratory is focused on phospholipid signaling in platelets and its contribution to inappropriate platelet activation. Ongoing projects are directed at understanding the roles of pleckstrin and lipid kinases in platelets. Pleckstrin (p47) was once solely known as an early marker of platelet activation; more recently it has been noted to contain the prototypic Pleckstrin Homology motif. Over the past half dozen years, work derived from our laboratory has demonstrated that pleckstrin plays a dominant role in the reorganization of the platelet, and lymphocyte, cytoskeleton. Furthermore, our laboratory has established these effects are regulated by pleckstrin phosphorylation, require critical lipid-binding residues contained with the amino-terminal Pleckstrin Homology domain, and have implicated an effector for this process to be the small GTP-binding protein, Rac. Additional work from our laboratory has helped define the role of phospholipid kinases in the pathway that is initiated by G-protein coupled receptors and ultimately leads to actin reorganization. Our studies use molecular and cellular biologic techniques to examine blood cell biology, and involve expression mutagenesis, single cell microinjection, genetic library screening, and murine homologous gene targeting ("gene knock-out").

Rotation projects

pleckstrin2 and actin assembly
PIP5K Ig and focal adhesions

Lab personnel:
Andrew Louden - Postdoctoral Fellow
Feng Wang - Postdoctoral Fellow
Seun-Ah Yang - Postdoctoral Fellow
Tami Bach - Postdoctoral Fellow
Michael Hu - Technician
Lurong Lian - Technician
Qing Chen - Undergraduate Student

Selected Publications:

Wang, Y., Chen, X., Lian, L., Bach, T.L., Golden, J., Morrisey, E.M., Abrams, C.S.: PIP5Kγ is required for cardiovascular and neuronal development Proceedings of the National Academy of Science (U.S.A.) 104 (28): 11748-53,2007.

Trivedi, C.M., Luo, Y., Yin, Z., Zhang, M., Floss, T., Goettlicher, M., Ruiz, P., Wurst, W., Ferrari, V., Abrams, C.S., Gruber, P., Epstein, J.A.: HDAC2 regulates the cardiac hypertrophic response by modulating GSK3β activity Nature Medicine 13 : 324-331,2007.

Wang, Y., Chen, X., Lian, L., Tang, T., Stalker, T.J., Sasaki, T., Brass, L.F., Choi, J.K., Hartwig, J.H., Abrams, C.S.: Loss of PIP5KIβ demonstrates that rapid PIP2 synthesis is required for IP3 formation Proceedings of the National Academy of Science (U.S.A.) 105 : 14064-14069,2008.

Pan, W., Choi, S.-C., Wang, H., Qin, Y., Volpicelli-Daley, L., Swan, L., Lucast, L., Khooo, C., Zhang, X., Li, L., Abrams, C.S., Sokol, S.Y., Wu, D.: Wnt3a-mediated formation of phosphatidylinositol 4,5-bisphosphate regulates LRP6 phosphorylation Science 321 : 1350-1353,2008.

Wang, Y., Litvinov, R.I., Chen, X., Lian, L., Bach, T.L., Petrich, B., Monkley, S., Critchley, D., Birnbaum, M.J., Weisel, J.W., Hartwig, J.H., Abrams, C.S.: Loss of PIP5Kγ, but not PIP5Kβ, impairs the integrity of the membrane cytoskeleton J. Clinical Investigation 118 (2): 812-819,2008.

Mao, Y.S., Yamaga, M., Zhu, X., Wei, M., Sun, H.-Q., Wang, J., Yun, M., Wang, Y., Di Paolo, G., Bennett, M., Mellman, I.S., Abrams, C.S., De Camilli, P.V., Lu, C.Y., and Yin, H.L.: Essential and unique roles of PIP5Kγ and α in Fcγ receptor-mediated phagocytosis J. Cell Biology Journal of Cell Biology 184 : 281-296,2009.

Lian, L., Wang, W., Flick, M., Choi, J., Scott, E., Degen, J., Lemmon, M.A., Abrams, C.S.: Loss of pleckstrin defines a novel pathway for PKC-mediated exocytosis Blood In press : 2009.

Min, S.H., Abrams, C.S.: Why do phosphatidylinositol kinases have so many isoforms? Biochemical J 423 (1): 99-108,2009.

Volpicelli-Daley, L.A., Lucast, L., Gong, L.-W., Liu, L., Sasaki, J., Sasaki, T., Abrams, C.S., Kanaho, Y., De Camilli, P.: Phosphatidylinositol 4-phosphate 5-kinases (PIPKIs) and phosphatidylinositol 4,5 bisphosphate [PI(4,5)P2] synthesis in the brain. J. Biologic Chemistry : 28708-14,2010.

Mitsios, J.V., Prévost, N., Kasirer-Friede, A., Gutierrez, E., Groisman, A., Abrams, C.S., Litvinov, R.I., Zemljic-Harpf, A., Ross, R.S., Shattil, S., J.: What is vinculin needed for in platelets? J. Thrombosis & Haemostasis : 2294-2304,2010.

View all publications

Academic Contact Info

421 Curie Blvd.

Philadelphia, PA 19104
Phone: (215) 898-1058
Patient appointments: 800-789-7366 (PENN)

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