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Bruce L. Levine, PhD Researcher

Barbara and Edward Netter Professor in Cancer Gene Therapy

Dr. Levine is employed by Penn Medicine.

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Clinical Specialties

Practice Locations and Appointments

Memberships

Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, National Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, National Abstract reviewer for American Society for Gene Therapy Annual Meeting, National Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, Gene Therapy, International Abstract reviewer for International Society for Cellular Therapy Annual Meeting, International American Association for the Advancement of Science, National American Society for Gene and Cell Therapy, National American Society of Gene Therapy, National Cambridge Healthtech Institute, National Cancer Prevention and Research Institute of Texas: Texas Access to Cancer Cell Therapies (TACCT), National Coordinating Abstract reviewer for American Society for Gene Therapy Annual Meeting, Cell Processing and Vector Production, National International Society for Cellular Therapy, International National Heart Lung and Blood Institute Cure Sickle Cell Initiative, National NIH Study Section, Immunology Integrated Review Group SSS-4 SBIR/STTR, National NIH/NHLBI Program: Production Assistance for Cellular Therapies, National NIH/NIAID Clinical Trial Planning (R34) Grants Study Section, National NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, National NIH/NIAID Study Section, Center for AIDS Research: D-CFAR, CFAR, National

Hospital Affiliation

Dr. Levine is employed by Penn Medicine.

Research

Description of Research Expertise:

Immunology, Cell and Gene Therapy

Selected Publications:

Garfall Alfred L, Dancy Ehren K, Cohen Adam D, Hwang Wei-Ting, Fraietta Joseph A, Davis Megan M, Levine Bruce L, Siegel Don L, Stadtmauer Edward A, Vogl Dan T, Waxman Adam, Rapoport Aaron P, Milone Michael C, June Carl H, Melenhorst J Joseph: T-cell phenotypes associated with effective CAR T-cell therapy in postinduction vs relapsed multiple myeloma. Blood advances 3 (19): 2812-2815,2019.

Chong Elise A, Levine Bruce L, Grupp Stephan A, Davis Megan M, Siegel Don L, Maude Shannon L, Gladney Whitney L, Frey Noelle V, Porter David L, Hwang Wei-Ting, Chong Emeline R, June Carl H, Schuster Stephen J: CAR T cell viability release testing and clinical outcomes: is there a lower limit? Blood : 2019.

Wang Kan, Liu Y I, Li Junxuan, Wang Ben, Bishop Reid, White Chip, DAS Amritava, Levine Aaron D, Ho Linda, Levine Bruce L, Fesnak Andrew D: A multiscale simulation framework for the manufacturing facility and supply chain of autologous cell therapies. Cytotherapy : 2019.

Haas Andrew R, Tanyi Janos L, O'Hara Mark H, Gladney Whitney L, Lacey Simon F, Torigian Drew A, Soulen Michael C, Tian Lifeng, McGarvey Maureen, Nelson Anne Marie, Farabaugh Caitlin S, Moon Edmund, Levine Bruce L, Melenhorst J Joseph, Plesa Gabriela, June Carl H, Albelda Steven M, Beatty Gregory L: Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers. Molecular therapy : the journal of the American Society of Gene Therapy : 2019.

Cohen Adam D, Garfall Alfred L, Stadtmauer Edward A, Melenhorst J Joseph, Lacey Simon F, Lancaster Eric, Vogl Dan T, Weiss Brendan M, Dengel Karen, Nelson Annemarie, Plesa Gabriela, Chen Fang, Davis Megan M, Hwang Wei-Ting, Young Regina M, Brogdon Jennifer L, Isaacs Randi, Pruteanu-Malinici Iulian, Siegel Don L, Levine Bruce L, June Carl H, Milone Michael C: B cell maturation antigen-specific CAR T cells are clinically active in multiple myeloma. The Journal of Clinical Investigation 130 : 126397,2019.

Stein Andrew M, Grupp Stephan A, Levine John E, Laetsch Theodore W, Pulsipher Michael A, Boyer Michael W, August Keith J, Levine Bruce L, Tomassian Lori, Shah Sweta, Leung Mimi, Huang Pai-Hsi, Awasthi Rakesh, Mueller Karen Thudium, Wood Patricia A, June Carl H: Tisagenlecleucel Model-Based Cellular Kinetic Analysis of Chimeric Antigen Receptor-T Cells. CPT: pharmacometrics & systems pharmacology : 2019.

Harrison Richard P, Zylberberg Ezequiel, Ellison Simon, Levine Bruce L: Chimeric antigen receptor-T cell therapy manufacturing: modelling the effect of offshore production on aggregate cost of goods. Cytotherapy 21 (2): 224-233,2019.

Mueller Karen T, Waldron Edward R, Grupp Stephan A, Levine John E, Laetsch Theodore W, Pulsipher Michael A, Boyer Michael W, August Keith, Hamilton Jason, Awasthi Rakesh, Stein Andrew M, Sickert Denise, Chakraborty Abhijit, Levine Bruce L, June Carl H, Tomassian Lori, Shah Sweta, Leung Mimi, Taran Tetiana, Wood Patricia A, Maude Shannon L: Clinical Pharmacology of Tisagenlecleucel in B-Cell Acute Lymphoblastic Leukemia. Clinical Cancer Research 24 (24): 6175,2018.

Ruella M, Xu J, Barrett DM, Fraietta JA, Reich TJ, Ambrose DE, Klichinsky M, Shestova O, Patel PR, Kulikovskaya I, Nazimuddin F, Bhoj VG, Orlando EJ, Fry TJ, Bitter H, Maude SL, Levine BL, Nobles CL, Bushman FD, Young RM, Scholler J, Gill SI, June CH, Grupp SA, Lacey SF, Melenhorst JJ: Induction of resistance to chimeric antigen receptor T cell therapy by transduction of a single leukemic B cell. Nature Medicine 24 (10): 1499-1503,2018.

Ghassemi S, Nunez-Cruz S, O'Connor RS, Fraietta JA, Patel PR, Scholler J, Barrett DM, Lundh SM, Davis MM, Bedoya F, Leferovich J, Lacey SF, Levine BL, Grupp SA, June CH, Melenhorst JJ, Milone MC: Reducing Ex Vivo Culture Improves the Anti-leukemic Activity of Chimeric Antigen Receptor (CAR)-T Cells Cancer Immunol Res. 6 (9): 100-1109,2018.

Academic Contact Info

Center for Cellular Immunotherapies
Smilow 8-114
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 746-1481
Patient appointments: 800-789-7366 (PENN)