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Brian Litt, MD

Brian Litt, MD Physician

Director, Penn Epilepsy Center Professor of Neurology and Professor of Bioengineering

Languages spoken:

  • French
  • Hebrew

Dr. Litt is employed by Penn Medicine.

About Dr. Brian Litt

Recognized by America's Top Doctors 2015 – 2017

Recognized by Best Doctors in America 2005 - 2012, 2015 - 2018

Recognized in Philadelphia magazine's annual Top Docs issues for 2018 and 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Neurology

Programs & Centers:

Board Certification:

  • Neurology, 1992

Clinical Expertise:

  • Abnormal EEG
  • Absence Epilepsy
  • Ambulatory EEG
  • Atonic Epilepsy
  • Convulsion
  • Cryptogenic Epilepsy
  • Deep Brain Stimulation
  • Drop Attack
  • Electroencephalography
  • Epilepsy
  • Epilepsy Monitoring Unit Evaluation (Emu)
  • Epileptic Confusional State
  • Epileptic Twilight State
  • Evaluation for Epilepsy Surgery
  • Familial Epilepsy
  • First Seizure Clinic
  • Focal Seizures
  • Frontal Lobe Epilepsy
  • Generalized Seizures
  • Grand Mal Seizures
  • Juvenile Myoclonic Epilepsy
  • Landau-Kleffner Syndrome
  • Lennox-Gastaut Syndrome
  • Maternal Seizures
  • Mesial Temporal Sclerosis
  • Myoclonic Seizures
  • New Onset Seizure
  • Occipital Lobe Epilepsy
  • Parietal Lobe Epilepsy
  • Petit Mal Seizure
  • Post-Traumatic Epilepsy
  • Post-Traumatic Seizure
  • Progressive Myoclonic Epilepsy
  • Responsive Neurostimulation
  • Simple Partial Seizures
  • Status Epilepticus
  • Temporal Lobe Epilepsy
  • Vagus Nerve Stimulation
  • Visualase MRI-Guided Laser Ablation
Show All Expertise

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oscar Health Plan of PA
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Johns Hopkins University School of Medicine
Residency: Johns Hopkins Hospital
Fellowship: Johns Hopkins Hospital


American Academy of Clinical Neurophysiology, International American Academy of Neurology, International American Board of Clinical Neurophysiology, International American Clinical Neurophysiology Society, International American Epilepsy Society, International American Federation of Musicians, National American Neurological Association, International Citizens United for Research in Epilepsy, National Eastern Electroencephalographic Society, International Epilepsy Foundation (National), National Epilepsy Foundation of South Eastern Pennsylvania, Local Epilepsy Foundation, National IEEE: Institute of Electrical and Electronics Engineers (Also includes membership in IEEE Engineering in Medicine and Biology Society)., International International Epilepsy Database (for high fidelity neurophysiological data), International International League Against Epilepsy, International International Seizure Prediction Group, International MC10, Start-up Company between UPenn, Harvard and Univ. of Illinois, National National Research Board of Ireland, Grant Reviewer, International National Science Foundation, Grant Reviewer, National NeuroVista, Inc, Member Scientific Advisory Board, National NIH Benchmarks Epilepsy Research Advisory Board to Director of the NIH, NINDS, 2004-present, National NIH Study Section, ZRG1 BDCN-F 11 M, Ad Hoc Member, National Philadelphia Neurological Society, Local Research Board of Canada, Grant Reviewer, International Research Board of Ireland, Grant Reviewer, International Society for Neuroscience, International The Epilepsy Therapy Project (ETP), National Veterans Administration, Washington, D.C., Scientific Reviewer, National

Hospital Affiliation

Dr. Litt is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Epilepsy, EEG, Clinical Neurophysiology, Epilepsy Surgery, Brain Stimulation, Implantable devices, network neuroscience, deep brain stimulation, functional imaging, neuroengineering, Biomedical engineering, computational neuroscience.

Selected Publications:

Litt Brian: Engineering the next generation of brain scientists. Neuron 86 (1): 16-20,2015.

Ives Z, Yan Z, Zheng N, Litt B, Wagenaar J: Looking at Everything in Context Conference paper, 7th biennial Conference on Innovative Data Systems Research (CDIR) : 2015.

Wulsin D, Fox E, Litt B: Modeling the complex dynamics and changing correlations of epileptic events Artificial Intelligence 216 : 55-75,2014.

Duygu Kuzum, Hajime Takano, Euijae Shim, Jason C. Reed, Halvor Juul, Andrew G. Richardson, Julius de Vries, Hank Bink, Mark Dichter, Timothy H. Lucas, Douglas A. Coulter, Ertugrul Cubukcu, Brian Litt: Transparent and flexible low noise graphene electrodes for simultaneous electrophysiology and neuroimaging Nature Communications 5 : 5259,2014.

Geller Aaron S, Burke John F, Sperling Michael R, Sharan Ashwini D, Litt Brian, Baltuch Gordon H, Lucas Timothy H, Kahana Michael J: Eye closure causes widespread low-frequency power increase and focal gamma attenuation in the human electrocorticogram. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 125 (9): 1764-73,2014.

Weixuan Chen, Xilin Liu, Litt B: Logistic-weighted regression improves decoding of finger flexion from electrocorticographic signals Conf Proc IEEE Eng Med Biol Soc. : 2629-32,2014.

Denison Timothy, Litt Brian: Advancing neuromodulation through control systems: a general framework and case study in posture-responsive stimulation. Neuromodulation : journal of the International Neuromodulation Society 17 Suppl 1 : 48-57,2014.

Escabi Monty Armando, Read Heather L, Viventi Jonathan, Kim Dae-Hyeong, Higgins Nathan C, Storace Douglas, Liu Andrew S K, Gifford Adam M, Burke John F, Campisi Matthew, Kim Yun-Soung, Avrin Andrew E, Van der Spiegel Jan, Huang Yonggang, Li Ming, Wu Jian, Rogers John A, Litt Brian, Cohen Yale E: A high-density, high-channel count, multiplexed µECoG array for auditory-cortex recordings. Journal of neurophysiology : 2014.

Rodriguez Merzagora Anna, Coffey Thomas J, Sperling Michael R, Sharan Ashwini, Litt Brian, Baltuch Gordon, Jacobs Joshua: Repeated stimuli elicit diminished high-gamma electrocorticographic responses. NeuroImage 85 Pt 2 : 844-52,2014.

Howbert J Jeffry, Patterson Edward E, Stead S Matt, Brinkmann Ben, Vasoli Vincent, Crepeau Daniel, Vite Charles H, Sturges Beverly, Ruedebusch Vanessa, Mavoori Jaideep, Leyde Kent, Sheffield W Douglas, Litt Brian, Worrell Gregory A: Forecasting seizures in dogs with naturally occurring epilepsy. PloS one 9 (1): e81920,2014.

View all publications

Academic Contact Info

Hospital: HUP
3 West Gates / 4283
34th Spruce Street

Lab: 301 Hayden Hall
3320 Smith Walk

Philadelphia, PA 19104
Phone: (215) 746-4850

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