Description of Research Expertise:
Dr. Anderson's research focuses on identifying clinical and molecular risk factors for neurocognitive impairment and other organ dysfunctions in critical illness. Dr. Anderson oversees Penn's cohort study of delirium and cognitive impairment in sepsis survivors. Current studies focus on 1) the role of systemic markers of cerebral injury to identify survivors at high risk of neurocognitive impairment, and 2) neuronal excitotoxicity as a mechanism of neuronal death and neurocognitive impairment in sepsis survivors.
Dr. Anderson also collaborates with Dr. Nuala Meyer, Dr. John Reilly and Dr. Michael Shashaty on epidemiologic and molecular studies of acute respiratory distress syndrome and acute kidney injury in critically ill patients.
Selected Publications:
Hippensteel JA, Anderson BJ, Orfila J, McMurtry S, Dietz RM, Su G, Ford J, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt R, Meyer NJ, Herson PS, Schmidt EP: Circulating heparan sulfate fragments mediate septic cognitive dysfunction Journal of Clinical Investigation 129 (4): 1779-1784,2019.
McDonald MD, Sandsmark DK, Palakshappa JA, Mikkelsen ME, Anderson BJ, Gutsche JT: Long-term Outcomes After Extracorporeal Life Support for Acute Respiratory Failure Journal of Cardiothoracic and Vascular Anesthesia 33 (1): 72-79,2019.
Reilly JP, Wang F, Jones TK, Palakshappa JA, Anderson BJ, Shashaty MGS, Dunn TG, Johansson ED, Riley TR, Lim B, Abbott J, Ittner CAG, Cantu E, Lin X, Mikacenic C, Wurfel MM, Christiani DC, Calfee CS, Matthay MA, Christie JD, Feng R, Meyer NJ: Plasma Angiopoietin-2 as a Potential Causal Marker in ARDS Development: Evidence from Mendelian Randomization and Mediation Analysis Intensive Care Medicine 44 (11): 1849-1858,2018.
Palakshappa JA, Reilly JP, Schweickert WD, Anderson BJ, Khoury V, Shashaty MG, Fitzgerald D, Forker C, Butler K, Ittner CA, Files DC, Bonk MP, Christie JD, Meyer NJ: Quantitative Peripheral Muscle Ultrasound in Sepsis: Muscle Area Superior to Thickness Journal of Critical Care 47 : 324-30,2018.
Anderson BJ, Chesley CF, Theodore M, Christie C, Tino R, Wysoczanski A, Ramphal K, Oyster M, Kalman L, Porteous MK, Bermudez CA, Cantu E, Kolson DL, Christie JD, Diamond JD: Incidence, Risk Factors, and Clinical Implications of Post-operative Delirium in Lung Transplant Recipients Journal of Heart and Lung Transplantation 37 (6): 755-762,2018.
Meyer NJ, Reilly JP, Anderson BJ, Palakshappa JA, Jones TK, Dunn TG, Shashaty MGS, Feng R, Christie JD, Palardy JE, Opal SM: Mortality Benefit of Recombinant Human Interleukin-1 Receptor Antagonist (rhIL1RA) for Sepsis Varies by Initial IL1RA Plasma Concentration Critical Care Medicine 46 (1): 21-28,2018.
Anderson BJ, Reilly JP, Shashaty MGS, Palakshappa JA, Wysoczanski A, Dunn TG, Kazi A, Tommasini A, Mikkelsen ME, Schweickert WD, Kolson DL, Christie JD, Meyer NJ: Admission plasma levels of the neuronal injury marker neuron specific enolase are associated with mortality and delirium in sepsis Journal of Critical Care 36 : 18-23,2016.
Reilly JP, Anderson BJ, Hudock KM, Dunn TG, Kazi A, Tommasini A, Charles D, Shashaty MGS, Mikkelsen ME, Christie JD, Meyer NJ: Neutropenic sepsis is associated with distinct clinical and biological characteristics: A cohort study of severe sepsis Critical Care 18 (20): 2016.
Reilly JP, Anderson BJ, Mangalmurti NS, Nguyen TD, Holena DN, Wu Q, Nguyen E, Reilly MP, Lanken PN, Christie JD, Meyer NJ, Shashaty MGS: The ABO Histo-Blood Group and Acute Kidney Injury Risk in Critically Ill Trauma and Sepsis Patients Clinical Journal of the American Society of Nephrology 10 (11): 1911-20,2015.
Cohen DG, Christie JD, Anderson BJ, Diamond JM, Judy RP, Shah RJ, Cantu E, Bellamy SL, Blumenthal NP, Demissie E, Hopkins RO, Mikkelsen ME: Cognitive function, mental health, and health-related quality of life after lung transplantation Annals of the American Thoracic Society 11 (4): 522-30,2014.
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