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Brenda B. Hoffman, MD

Brenda B. Hoffman, MD Physician

Medical Director, Acute Dialysis Program Professor of Clinical Medicine

Dr. Hoffman is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Renal Electrolyte and Hypertension

Programs & Centers:

Board Certification:

  • Nephrology, 1996

Clinical Expertise:

  • Alport Syndrome
  • Berger's Disease (IgA Nephropathy)
  • Cardiorenal Syndrome (CRS)
  • Diabetic Kidney Diseases
  • Dialysis
  • Electrolyte Disorders
  • End-Stage Kidney Disease
  • Focal Segmental Glomerulosclerosis (FSGS)
  • Goodpasture Syndrome
  • Granulomatosis with Polyangiitis
  • Hemodialysis
  • Henoch–Schönlein purpura
  • HIV-Assoicated Nephropathy
  • Home Dialysis
  • Hypercalcemia
  • Hyperparathyroidism
  • Hypertension
  • Interstitial Cystitis (IC)
  • Kidney Cancer
  • Kidney Cyst (Renal Cyst)
  • Kidney Failure
  • Kidney Polycystic Diseases
  • Kidney Stones (Nephrolithiasis)
  • Kidney Transplant Rejection
  • Kidney Transplantation
  • Leg Swelling (Edema)
  • Living Donor Kidney Transplantation
  • Lupus Nephritis
  • Metabolic Acidosis
  • Nephritis
  • Nephrotic Syndrome
  • Nephrotoxicity
  • Partial Nephrectomy
  • Peritoneal Dialysis
  • Renal Disease and Pregnancy
  • Renal Osteodystrophy
  • Renovascular Hypertension
  • Ultrasound Guided Biopsy
  • Uremia
  • Vasculitis
View More

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Care
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Graduate Hospital
Fellowship: Hospital of the University of Pennsylvania


American Society of Nephrology, National International Society of Nephrology, International National Kidney Foundation, National Women in Nephrology, National

Hospital Affiliation

Dr. Hoffman is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Selected Publications:

Boyle, SM, Jacobs, B, Sayni, FA, Hoffman, B: Management of the Dialysis Patient with Sickle Cell Disease Seminars in Dialysis 29 (1): 62-70,2016.

Barbieri J, Seshasai R, Shemash A, Sedrak M, Hoffman B, Alley E: Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome Journal of Thoracic Oncology 8 (6): e57-8,2013.

Tan A, Hoffman B, Rosas SE: Patient perception of risk factors associated with chronic kidney disease morbidity and mortality Ethnicity and Disease 20 : 106-108,2010.

Hoffman BB: Peritoneal Dialysis Current Diagnosis and Treatment in Nephrology and Hypertension Chapter 51 (Section 8): 444-452,2009.

Hoffman BB: Surgery in the Patient with Kidney Disease Medical Management of the Surgical Patient 3rd edition Chapter 18 : 605-632,2008.

Chen S, Hoffman BB, Jim B, Lee JS, Kopp JB, Ziyadeh FN: Tubular cells from TGF-beta 1 knockout mice show decreased fibronectin and blunted hypertrophy in high glucose Kidney Intl 65 : 1191-1204,2004.

Chen S, Lee JS, Hoffman BB, Ziyadeh FN: Cultured tubule cells from TGF-beta 1 knockout mice exhibit impaired hypertrophy and fibronectin expression in high glucose JASN 14 : 128A,2003.

Dell M, Hoffman BB, Leonard MB, Ziyadeh FN, Schulman SL: Increased urinary transforming growth factor beta-1 (TGF-B1) excretion in children with posterior urethral valves Urology 56 (2): 311-4,2000.

Isono M, Mogyorosi A, Han DC, Hoffman BB, Ziyadeh FN: Stimulation of TGF-B type II receptor gene expression in mouse mesangial cells by high glucose and in diabetic kidney Amer Journal of Physiology 278 : F830-F838,2000.

Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti transforming growth factor-beta antibody in db/db diabetic mice PNAS 97 (14): 8015-20,2000.

Han DC, Hoffman BB, Guo J, Ziyadeh FN: Therapy with antisense TGF-B1 oligodeoxynucleotides reduces kidney weight and matrix mRNA's in diabetic mice Amer Journal of Physiology 278 : F628-F634,2000.

Academic Contact Info

240 Medical Office Building
Penn Presbyterian Medical Center
39th & Market Street

Philadelphia, PA 19104
Phone: (215) 662-8730
Patient appointments: 800-789-7366 (PENN)

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