Find a Doctor or Practice Location

Are you a referring physician?
I am searching for a
Reset Form
Brenda B. Hoffman, MD

Brenda B. Hoffman, MD Physician

Medical Director, Acute Dialysis Program
Associate Professor of Clinical Medicine

Dr. Hoffman is a Penn Medicine employed physician.

Clinical Specialties


  • Renal Electrolyte and Hypertension

Programs & Centers:

Board Certification:

  • Nephrology, 1996

Clinical Expertise:

  • Chronic Kidney Diseases
  • Diabetic Kidney Diseases
  • Hospital Medicine
  • Kidney Biopsy
  • Kidney Disease
  • Kidney Drug-related Adverse Effects
  • Kidney Failure
  • Kidney Scleroderma
  • Kidney Stones
  • Kidney Transplantation
  • Nephritis
  • Nephrology Consultation
  • Nephrotic Syndrome
  • Proteinuria
  • Renal Artery Disease
  • Renal Osteodystrophy
  • Renovascular Hypertension

Description of Clinical Expertise

Chronic kidney disease, Acute kidney injury, In center hemodialysis, Peritoneal dialysis, Acute dialysis, Kidney stones, Diabetic kidney disease

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Graduate Hospital
Fellowship: Hospital of the University of Pennsylvania


American Society of Nephrology, National International Society of Nephrology, International National Kidney Foundation, National Women in Nephrology, National

Hospital Affiliation

Dr. Hoffman is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Selected Publications:

Boyle, SM Jacobs, B Sayni, FA Hoffman, B: Management of the Dialysis Patient with Sickle Cell Disease Seminars in Dialysis 29 (1): 62-70,2016.

Barbieri J, Seshasai R, Shemash A, Sedrak M, Hoffman B, Alley E: Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome Journal of Thoracic Oncology 8 (6): e57-8,2013.

Tan A, Hoffman B, Rosas SE: Patient perception of risk factors associated with chronic kidney disease morbidity and mortality Ethnicity and Disease 20 : 106-108,2010.

Hoffman BB: Peritoneal Dialysis: In Renal Replacement Therapy Current Diagnosis and Treatment in Nephrology and Hypertension Chapter VIII (51): 2009.

Hoffman BB: Surgery in the Patient with Kidney Disease Medical Management of the Surgical Patient 3rd edition Chapter 18 : 605-632,2008.

Chen S, Hoffman BB, Jim B, Lee JS, Kopp JB, Ziyadeh FN: Tubular cells from TGF-beta 1 knockout mice show decreased fibronectin and blunted hypertrophy in high glucose Kidney Intl 65 : 1191-1204,2004.

Chen S, Lee JS, Hoffman BB, Ziyadeh FN: Cultured tubule cells from TGF-beta 1 knockout mice exhibit impaired hypertrophy and fibronectin expression in high glucose JASN 14 : 128A,2003.

Dell M, Hoffman BB, Leonard MB, Ziyadeh FN, Schulman SL: Increased urinary transforming growth factor beta-1 (TGF-B1) excretion in children with posterior urethral valves Urology 56 (2): 311-4,2000.

Isono M, Mogyorosi A, Han DC, Hoffman BB, Ziyadeh FN: Stimulation of TGF-B type II receptor gene expression in mouse mesangial cells by high glucose and in diabetic kidney Amer Journal of Physiology 278 : F830-F838,2000.

Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA, Sharma K: Long term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti transforming growth factor-beta antibody in db/db diabetic mice PNAS 97 (14): 8015-20,2000.

Han DC, Hoffman BB, Guo J, Ziyadeh FN: Therapy with antisense TGF-B1 oligodeoxynucleotides reduces kidney weight and matrix mRNA's in diabetic mice Amer Journal of Physiology 278 : F628-F634,2000.

Academic Contact Info

240 Medical Office Building
Penn Presbyterian Medical Center
39th & Market Street

Philadelphia, PA 19104
Phone: (215) 662-8730
Fax: (215) 243-4686
Patient appointments: 800-789-PENN (7366)

Related Links