Find a Doctor or Practice Location

Are you a referring physician?
I am searching for a
Reset Form
Brenda B. Hoffman, MD

Brenda B. Hoffman, MD Physician

Medical Director, Acute Dialysis Program Associate Professor of Clinical Medicine

Dr. Hoffman is employed by Penn Medicine.

Request an Appointment
No Patient Satisfaction Reviews
Why not?

There is no publicly available rating for this medical professional for one of the following reasons:

  1. He or she is not employed by Penn Medicine.
  2. He or she does not see patients.
  3. He or she sees patients but has not yet received the minimum 30 patient satisfaction reviews in the past 12 months, ensuring that the rating is statistically reliable and a true reflection of patient satisfaction.

Clinical Specialties


  • Renal Electrolyte and Hypertension

Programs & Centers:

Board Certification:

  • Nephrology, 1996

Clinical Expertise:

  • Chronic Kidney Diseases (CKD)
  • Diabetic Kidney Diseases
  • Kidney Biopsy
  • Kidney Disease
  • Kidney Drug-related Adverse Effects
  • Kidney Failure
  • Kidney Stones (Nephrolithiasis)
  • Kidney Transplantation
  • Nephritis
  • Nephrology Consultation
  • Nephrotic Syndrome
  • Proteinuria
  • Renal Artery Disease
  • Renal Osteodystrophy
  • Renovascular Hypertension
  • Scleroderma Kidney Disease

Description of Clinical Expertise

Chronic kidney disease, Acute kidney injury, In center hemodialysis, Peritoneal dialysis, Acute dialysis, Kidney stones, Diabetic kidney disease

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School:
Residency: Graduate Hospital
Fellowship: Hospital of the University of Pennsylvania


American College of Physicians, National American Society of Nephrology, National International Society of Nephrology, International International Society of Peritoneal Dialysis, International National Kidney Foundation, National Women in Nephrology, National

Hospital Affiliation

Dr. Hoffman is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Selected Publications:

Boyle, SM Jacobs, B Sayni, FA Hoffman: Management of the Dialysis Patient with Sickle Cell Disease Seminars in Dialysis 29 (1): 62-70,2016.

Barbieri J, Seshasai R, Shemash A, Sedrak M, Hoffman B: Thymic neuroendocrine tumor presenting with the ectopic ACTH syndrome Journal of Thoracic Oncology 8 (6): e57-8,2013.

Tan A, Hoffman B: Patient perception of risk factors associated with chronic kidney disease morbidity and mortality Ethnicity and Disease 20 : 106-108,2010.

Peritoneal Dialysis: In Renal Replacement Therapy Current Diagnosis and Treatment in Nephrology and Hypertension Chapter VIII (51): 2009.

Surgery in the Patient with Kidney Disease Medical Management of the Surgical Patient 3rd edition Chapter 18 : 605-632,2008.

Chen S, Hoffman BB, Jim B, Lee JS, Kopp JB: Tubular cells from TGF-beta 1 knockout mice show decreased fibronectin and blunted hypertrophy in high glucose Kidney Intl 65 : 1191-1204,2004.

Chen S, Lee JS, Hoffman BB: Cultured tubule cells from TGF-beta 1 knockout mice exhibit impaired hypertrophy and fibronectin expression in high glucose JASN 14 : 128A,2003.

Dell M, Hoffman BB, Leonard MB, Ziyadeh FN: Increased urinary transforming growth factor beta-1 (TGF-B1) excretion in children with posterior urethral valves Urology 56 (2): 311-4,2000.

Isono M, Mogyorosi A, Han DC, Hoffman BB: Stimulation of TGF-B type II receptor gene expression in mouse mesangial cells by high glucose and in diabetic kidney Amer Journal of Physiology 278 : F830-F838,2000.

Ziyadeh FN, Hoffman BB, Han DC, Iglesias-De La Cruz MC, Hong SW, Isono M, Chen S, McGowan TA: Long term prevention of renal insufficiency, excess matrix gene expression, and glomerular mesangial matrix expansion by treatment with monoclonal anti transforming growth factor-beta antibody in db/db diabetic mice PNAS 97 (14): 8015-20,2000.

Han DC, Hoffman BB, Guo J: Therapy with antisense TGF-B1 oligodeoxynucleotides reduces kidney weight and matrix mRNA's in diabetic mice Amer Journal of Physiology 278 : F628-F634,2000.

Academic Contact Info

240 Medical Office Building
Penn Presbyterian Medical Center
39th & Market Street

Philadelphia, PA 19104
Phone: (215) 662-8730
Patient appointments: 800-789-7366 (PENN)

Related Links