Description of Research Expertise:
My research interests are in translational cardiovascular epidemiology with a focus on the study of novel signaling pathways and mechanisms in human heart failure, cardiac remodeling, and cancer therapy cardiotoxicity. Current areas of research include:
1) Neuregulin Signaling:
We are interested in defining the relevance of circulating neuregulin as it relates to human heart failure and cardiac remodeling. I am the principal investigator of a longitudinal study determining the association between circulating neuregulin levels and cardiac remodeling and clinical outcomes in the Penn Heart Failure Study and the Chronic Renal Insufficiency Cohort.
2) Mechanistic Biomarker Studies in Cancer Therapy Cardiotoxicity:
We are interested in defining novel circulating biomarkers and genetic variations predictive of cancer therapy cardiotoxicity. Our objective is to gain mechanistic and translational insight into the pathophysiology of this disease. We have ongoing studies in specific pathways and biomarkers of interest, as well as proteomics discovery across various cardiotoxic regimens.
3) Myocardial Mechanics in Cancer Therapy Cardiotoxicity and Heart Failure:
We are interested in gaining insight into alterations in myocardial mechanics and sensitive measures of cardiac function, as defined by echocardiography, in patients exposed to cardiotoxic chemotherapy regimens as well as patients with chronic heart failure.
Grisham R, Ky B, Tewari KS, Chaplin DJ, Walker J: Clinical Trial Experience with CA4P Anticancer Therapy: Focus on Cardiovascular Adverse Events and Hypertension Management Gynecologic Oncology Research 5 (1): 2018.
Brown J, Rickels M, Troxel A, Zemel B, Damjanov N, Ky B, Rhim A, Rustgi A, Courneya KS, Schmitz K: Dose-response effects of exercise on insulin among colon cancer survivors Endocrine Related Cancer 25 (1): 2018.
Catino AB, Hubbard RA, Chirinos JA, Townsend R, Keefe S, Haas NB, Puzanov I, Fang JC, Agarwal N, Hyman D, Smith AM, Gordon M, Plappert T, Englefield V, Narayan V, Ewer S, Elamm C, Lenihan DJ, Ky B.: Longitudinal Assessment of Vascular Function with Sunitinib in Patients with Metastatic Renal Cell Carcinoma. Circulation Heart Failure : 2018.
Zhang KW, Finkelman BS, Gulati G, Narayan HK, Upshaw J, Narayan V, Plappert T, Englefield V, Smith AM, Zhang C, Hundley WG, Ky B: Abnormalities in Three-Dimensional Left Ventricular Mechanics with Anthracycline Chemotherapy are Associated with Systolic and Diastolic Dysfunction Journal of the American College of Cardiology Imaging : 2018.
DiLorenzo MP, Wang Y, Ky B, Elci O, Goldmuntz E, Mercer-Rosa L: Longitudinal Changes in Right Ventricular Function in Tetralogy of Fallot in the Initial Years after Surgical Repair Journal of the American Society of Echocardiography : 2018.
Narayan, V and Ky, B: Common Cardiovascular Complications of Cancer Therapy: Epidemiology, Risk Prediction, and Prevention Annual Review of Medicine 69 : 97-111,2018.
Brown J, Damjanov N, Courneya KS, Troxel A, Zemel B, Rickels MR, Ky B, Rhim A, Rustgi A, Schmitz K: A Randomized Dose-Response Trial of Aerobic Exercise and Health-Related Quality of Life in Colon Cancer Survivors Pscyho-Oncology : 2018.
Waxman AJ, Clasen S, Hwang WT, Garfall A, Vogl DT, Carver J, O'Quinn R, Cohen AD, Stadtmauer E, Ky B, Weiss BM.: Carfilzomib-Associated Cardiovascular Adverse Events: A Systematic Review and Meta-Analysis JAMA Oncology : e174519,2017.
Truitt R, Mu A, Corbin EA, Vite A, Brandimarto J, Ky B, Margulies KB: Increased Afterload Augments Sunitinib-Induced Cardiotoxicity in an Engineered Cardiac Microtissue Model JACC Basic Translational Science : 2017.
Zhao H, O’Quinn R, Ambrose M, Jagasia D, Ky B, Wald J, Ferrari V, Kirkpatrick J, and Han Y: Contrast Echocardiography Provides the Greatest Impact in Patients with Reduced Ejection Fraction Journal of the American Society of Echocardiography : 2017.
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