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Bonnie Ky, MD, MSCE

Bonnie Ky, MD, MSCE Physician

Assistant Professor of Medicine
Assistant Professor of Epidemiology in Biostatistics and Epidemiology

Languages spoken:

  • Mandarin

Dr. Ky is a Penn Medicine employed physician.

Clinical Specialties


  • Cardiology

Programs & Centers:

  • Noninvasive Heart Testing

Board Certification:

  • Cardiovascular Disease, 2007

Clinical Expertise:

  • Consultative Cardiology
  • Echocardiographic Stress Testing
  • Echocardiography
  • Non-Invasive Cardiac Imaging
  • Women Cardiology

Description of Clinical Expertise

My clinical expertise is in noninvasive imaging by echocardiography and the care of patients in cardio-oncology.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania


American College of Cardiology Cardio Oncology, National American College of Cardiology, National American Society of Clinical Oncology, National American Society of Echocardiography, National Cardiac Safety Research Consortium, National Eastern Cooperative Group/American College of Radiation Network, National Heart Failure Society of America, National International CardiOncology Society, International NCI Community Oncology Cardiotoxicity Task Force, National

Hospital Affiliation

Dr. Ky is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

My research interests are in translational cardiovascular epidemiology with a focus on the study of novel signaling pathways and mechanisms in human heart failure, cardiac remodeling, and cancer therapy cardiotoxicity. Current areas of research include:

1) Neuregulin Signaling:
We are interested in defining the relevance of circulating neuregulin as it relates to human heart failure and cardiac remodeling. I am the principal investigator of a longitudinal study determining the association between circulating neuregulin levels and cardiac remodeling and clinical outcomes in the Penn Heart Failure Study and the Chronic Renal Insufficiency Cohort.

2) Mechanistic Biomarker Studies in Cancer Therapy Cardiotoxicity:
We are interested in defining novel circulating biomarkers and genetic variations predictive of cancer therapy cardiotoxicity. Our objective is to gain mechanistic and translational insight into the pathophysiology of this disease. We have ongoing studies in specific pathways and biomarkers of interest, as well as proteomics discovery across various cardiotoxic regimens.

3) Myocardial Mechanics in Cancer Therapy Cardiotoxicity and Heart Failure:
We are interested in gaining insight into alterations in myocardial mechanics and sensitive measures of cardiac function, as defined by echocardiography, in patients exposed to cardiotoxic chemotherapy regimens as well as patients with chronic heart failure.

Selected Publications:

French B, Wang L, Ky B, Fang JC, Sweitzer NK, Cappola TP.: Prognostic value of galectin-3 for adverse outcomes in chronic heart failure. Journal of Cardiac Failure 22 (4): 256-62,2016.

Armenian SH, Xu L, Ky B, Sun C, Farol L, Pal S, Douglas PS, Bhatia S, Chao C.: Late Occurring Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community Based Retrospective Study. Journal of Clinical Oncology 34 (10): 1120-30,2016.

Narayan HK, Khan AM, French B, Plappert T, Hyman D, Bajulaiye A, DeMichele A, Domchek S, Clark A, Fox K, Matro J, Bradbury A, Carver JR, Ky B.: Echocardiography-Derived Measures of Myocardial Mechanics Predict Cardiotoxicity with Breast Cancer Therapy. Journal of the American College of Cardiology Imaging. Journal of the American College of Cardiology Imaging : 2016.

Brown JC, Troxel AB, Ky B, Damjanov N, Zemel BS, Rickels MR, Rhim AD, Rustgi AK, Courneya KS, Schmitz KH: A randomized phase II dose-response exercise trial among Colon Cancer Survivors: Purpose, Study Design, methods, and recruitment results. Contemp Clinical Trials 47 : 366-375,2016.

Wang GJ, Shaw PA, Townsend RR, Anderson AH, Xie D, Wang X, Nessel LC, Mohler III ER, Sozio SM, Jaar BG, Chen J, Wright J, Taliercio JJ, Ojo A, Ricardo AC, Lustigiva E, Fairman RM, Feldman HI, Ky B: Sex Differences in the Incidence of Peripheral Artery Disease (PAD) in the Chronic Renal Insufficiency Cohort (CRIC) Circulation: Cardiovascular Quality and Outcomes 1 : S86-93,2016.

Porteous MK, Ky B, Fitzpatrick JN, Plappert T, Diamond JM, Shah RJ, Brown M, Christie JD, Kawut SM: Diastolic Dysfunction Increases the Risk of Primary Graft Dysfunction After Lung Transplantation American Journal of Respiratory and Critical Care Medicine : 2016.

St. John Sutton, M. Cerkvenik J, Borlaug BA, Daubert C, Gold MR, Ghio S, Linde C, Ky B: The Effects of Cardiac Resynchronization Therapy on Cardiac Remodeling and Contractile Function: Results from the Resynchronization reverses Remodeling in Systolic left ventricular dysfunction (REVERSE) Journal of the American Heart Association 4 (9): 2015.

Putt ME, Hahn Shalkey V, Sawaya H, French B, Sebag I, Plana JC, Januzzi JL, Tan TC, Cohen V, Banchs J, Carver J, Wiegers SE, Martin RP, Picard MH, Gerszten RE, Halpern EF, Passeri J, Kuter I, Scherrer-Crosbie M, Ky B.: Longitudinal Changes in Multiple Biomarkers Are Associated with Cardiotoxicity in Breast Cancer Patients Treated with Doxorubicin, Taxanes, and Trastuzumab. Clinical Chemistry 61 (9): 1164-72,2015.

Tchou J, Lam L, Li YR, Edwards C, Ky B, Zhang H: Monitoring Serum HER2 Levels in Breast Cancer Patients Springer Plus Breast Cancer Collection 4 (237): 2015.

Haas, N Manola J, Ky B, Flaherty K, Uzzo RG, Kane CJ, Jewett M, Wood CG, Atkin MB, Dutcher JJ, DiPaolo RS: Effects of Sorafenib and Sunitinib on Cardiac Function in a Population without Overt Metastases: Cardiac Sub-study of a Phase III Trial of Sunitinib or Sorafenib or Placebo in Patients with High Risk Resected Renal Cell Carcinoma (E2805) Clinical Cancer Research : 2015.

View all publications

Academic Contact Info

Hospital of the University of Pennsylvania
11-105 Smilow Center for Translational Research
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 573-6606
Fax: (215) 746-7415
Patient appointments: 800-789-PENN (7366)

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