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Bonnie Ky, MD, MSCE

Bonnie Ky, MD, MSCE Physician

Assistant Professor of Epidemiology in Biostatistics and Epidemiology Assistant Professor of Medicine

Languages spoken:

  • Mandarin

Dr. Ky is employed by Penn Medicine.

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Clinical Specialties

Specialty:

  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 2007

Clinical Expertise:

  • Consultative Cardiology
  • Echocardiographic Stress Testing
  • Echocardiography
  • Non-Invasive Cardiac Imaging
  • Women Cardiology

Description of Clinical Expertise

My clinical expertise is in noninvasive imaging by echocardiography and the care of patients in cardio-oncology.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American College of Cardiology, National American Heart Association, National American Society of Clinical Oncology , National American Society of Echocardiography, National Cardiac Safety Research Consortium, National Eastern Cooperative Group/American College of Radiation Network, National Heart Failure Association of the European Society of Cardiology, International Heart Failure Society of America, National International CardiOncology Society, International NCI Community Oncology Cardiotoxicity Task Force, National NIH, Clinical and Integrative Cardiovascular Sciences Study Section, National

Hospital Affiliation

Dr. Ky is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

My research interests are in translational cardiovascular epidemiology with a focus on the study of novel signaling pathways and mechanisms in human heart failure, cardiac remodeling, and cancer therapy cardiotoxicity. Current areas of research include:

1) Neuregulin Signaling:
We are interested in defining the relevance of circulating neuregulin as it relates to human heart failure and cardiac remodeling. I am the principal investigator of a longitudinal study determining the association between circulating neuregulin levels and cardiac remodeling and clinical outcomes in the Penn Heart Failure Study and the Chronic Renal Insufficiency Cohort.


2) Mechanistic Biomarker Studies in Cancer Therapy Cardiotoxicity:
We are interested in defining novel circulating biomarkers and genetic variations predictive of cancer therapy cardiotoxicity. Our objective is to gain mechanistic and translational insight into the pathophysiology of this disease. We have ongoing studies in specific pathways and biomarkers of interest, as well as proteomics discovery across various cardiotoxic regimens.


3) Myocardial Mechanics in Cancer Therapy Cardiotoxicity and Heart Failure:
We are interested in gaining insight into alterations in myocardial mechanics and sensitive measures of cardiac function, as defined by echocardiography, in patients exposed to cardiotoxic chemotherapy regimens as well as patients with chronic heart failure.

Selected Publications:

Zhao H, O’Quinn R, Ambrose M, Jagasia D, Ky B, Wald J, Ferrari V, Kirkpatrick J: Contrast Echocardiography Provides the Greatest Impact in Patients with Reduced Ejection Fraction Journal of the American Society of Echocardiography : 2017.

Brown J, Rickels M, Troxel A, Zemel B, Damjanov N, Ky B, Rhim A, Rustgi A, Courneya KS: Dose-response effects of exercise on insulin among colon cancer survivors Endocrine Related Cancer : 2017.

Brown JC, Zemel BS, Troxel AB, Rickels MR, Damjanov N, Ky B, Rhim AD, Rustgi AK, Courneya KS: Dose-response Effects of Aerobic Exercise on Body Composition Among Colon Cancer Survivors: A Randomised Controlled Trial British Journal of Cancer : 2017.

Wells QS, Veatch OJ, Fessel JP, Joon AY, Mosley JD, Held EP, Lindsay CS, Shaffer CM, Weeke P, Van Driest SL, Karnes JH, Blair MA, Lagrone LW, Su YR, Bowton EA, Feng Z, Ky B, Lenihan DJ, Fisch MJ, Denny JC: Genome-wide association and pathway analysis of left ventricular function after anthracycline exposure in adults Pharmacogenetics and Genomics 27 (7): 247-254,2017.

Finkelman B, Putt M, Wang T, Wang L,Narayan H, Domchek S, DeMichele A, Fox K, Matro J, Shah P, Clark A, Bradbury A, Narayan V, Carver JR, Tang W: Arginine-Nitric Oxide Metabolites and Cardiac Dysfunction in Patients With Breast Cancer Journal of the American College of Cardiology 70 (2): 152-162,2017.

Brown JC, Troxel AB, Ky B, Damjanov N, Zemel BS, Rickels MR, Rhim AD, Rustgi AK, Courneya KS: Dose-Response Effects of Aerobic Exercise among Colon Cancer Survivors: A Randomized Phase II Trial Clinical Colorectal Cancer : 2017.

Narayan HK, Finkelman BS, French B, Plappert T, Hyman D, Smith AM, Margulies KB: Detailed Echocardiographic Phenotyping in Breast Cancer Patients: Associations with Ejection Fraction Decline, Recovery, and Heart Failure Symptoms over 3 Years of Followup Circulation 135 (15): 1397-1412,2017.

Aimo A, Vergaro G, Passino C, Ripoli A, Ky B, Miller WL, Bayes-Genis A, Anand I, Januzzi JL: Prognostic Value of Soluble Suppression of Tumorigenicity-2 in Chronic Heart Failure: A Meta-Analysis. JACC Heart Failure 5 (4): 280-286,2017.

Narayan V, Keefe S, Haas N, Wang L, Puzanov I, Putt M, Catino A, Fang J, Agarwal N, Hyman D, Smith AM, Finkelman BS, Nayan HK, Ewer S, ElAmm C, Lenihan D: Prospective Evaluation of Sunitinib-Induced Cardiotoxicity in Patients with Metastatic Renal Cell Carcinoma. Clinical Cancer Research : 2017.

Kawut SM, Archer-Chicko CL, DiMichele A, Fritz JS, Klinger JR, Ky B, Palevsky HI, Palmisciano AJ, Patel M, Pinder D, Propert KJ, Smith KA, Stanczyk F, Tracy R, Vaidya A, Whittenhall ME: Anastrozole in Pulmonary Arterial Hypertension (AIPH): A Randomized, Double-Blind Placebo-Controlled Trial. American Journal of Respiratory and Critical Care Medicine 195 (3): 360-368,2017.

View all publications

Academic Contact Info

Hospital of the University of Pennsylvania
11-105 Smilow Center for Translational Research
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 573-6606
Patient appointments: 800-789-7366 (PENN)

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