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Bonnie Ky, MD, MSCE

Bonnie Ky, MD, MSCE Physician

Assistant Professor of Medicine Assistant Professor of Epidemiology in Biostatistics and Epidemiology

Languages spoken:

  • Mandarin

Dr. Ky is a Penn Medicine employed physician.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties

Specialty:

  • Cardiology

Programs & Centers:

Board Certification:

  • Cardiovascular Disease, 2007

Clinical Expertise:

  • Consultative Cardiology
  • Echocardiographic Stress Testing
  • Echocardiography
  • Non-Invasive Cardiac Imaging
  • Women Cardiology

Description of Clinical Expertise

My clinical expertise is in noninvasive imaging by echocardiography and the care of patients in cardio-oncology.

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Hospital of the University of Pennsylvania
Fellowship: Hospital of the University of Pennsylvania

Memberships

American College of Cardiology Annual Meeting Program Committee, National American College of Cardiology Annual Meeting Program Committee, National American College of Cardiology, National American Heart Association, National American Society of Clinical Oncology , National American Society of Echocardiography, National Cardiac Safety Research Consortium, National Eastern Cooperative Group/American College of Radiation Network, National Heart Failure Society of America, National International CardiOncology Society, International NCI Community Oncology Cardiotoxicity Task Force, National NIH, Clinical and Integrative Cardiovascular Sciences Study Section, Reviewer, National

Hospital Affiliation

Dr. Ky is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.

Research

Description of Research Expertise:

My research interests are in translational cardiovascular epidemiology with a focus on the study of novel signaling pathways and mechanisms in human heart failure, cardiac remodeling, and cancer therapy cardiotoxicity. Current areas of research include:

1) Neuregulin Signaling:
We are interested in defining the relevance of circulating neuregulin as it relates to human heart failure and cardiac remodeling. I am the principal investigator of a longitudinal study determining the association between circulating neuregulin levels and cardiac remodeling and clinical outcomes in the Penn Heart Failure Study and the Chronic Renal Insufficiency Cohort.


2) Mechanistic Biomarker Studies in Cancer Therapy Cardiotoxicity:
We are interested in defining novel circulating biomarkers and genetic variations predictive of cancer therapy cardiotoxicity. Our objective is to gain mechanistic and translational insight into the pathophysiology of this disease. We have ongoing studies in specific pathways and biomarkers of interest, as well as proteomics discovery across various cardiotoxic regimens.


3) Myocardial Mechanics in Cancer Therapy Cardiotoxicity and Heart Failure:
We are interested in gaining insight into alterations in myocardial mechanics and sensitive measures of cardiac function, as defined by echocardiography, in patients exposed to cardiotoxic chemotherapy regimens as well as patients with chronic heart failure.

Selected Publications:

Narayan HK, Finkelman BS, French B, Plappert T, Hyman D, Smith AM, Margulies KB, Ky B.: Detailed Echocardiographic Phenotyping in Breast Cancer Patients: Associations with Ejection Fraction Decline, Recovery, and Heart Failure Symptoms over 3 Years of Followup. Circulation : 2017.

O'Farrell ACO, Evans R, Silvola JMU, Miller IS, Conroy E, Hector S, Cary M, Murray D, Jarzabek MA, Maratha A, Alamanou M, Udupi GM, Shiels L, Pallaud C, Saraster A, Liljenback H, Jauhiainen M, Oikonen V, Ducret A, Cutler P, Mc Auliffe F, Rousseau JA, Lecomte R, Gacson S, Ky B, Force T, Arany Z, Knuuti J, Gallagher W, Roivainen A, Byrne AT: A Novel Positron Emission Tomography (PET) Approach to Monitor Cardiac Metabolic Pathway Remodeling in Response to Sunitinib Malate Plos One : 2017.

Narayan V, Keefe S, Haas N, Wang L, Puzanov I, Putt M, Catino A, Fang J, Agarwal N, Hyman D, Smith AM, Finkelman BS, Nayan HK, Ewer S, ElAmm C, Lenihan D, Ky B.: Prospective Evaluation of Sunitinib-Induced Cardiotoxicity in Patients with Metastatic Renal Cell Carcinoma Clinical Cancer Research : 2017.

Aimo A, Vergaro G, Passino C, Ripoli A, Ky B, Miller WL, Bayes-Genis A, Anand I, Januzzi JL, Emdin M: Prognostic Value of Soluble Suppression of Tumorigenicity-2 in Chronic Heart Failure: A Meta-Analysis JACC Heart Fail : 2016.

Narayan HK, French B, Khan AM, Plappert T, Hyman D, Bajulaiye A, Domchek S, DeMichele A, Clark A, Matro J, Bradbury A, Fox K, Carver JR, Ky B: Noninvasive Measures of Ventricular-Arterial Coupling and Circumferential Strain Predict Cancer Therapeutics-Related Cardiac Dysfunction. JACC Cardiovascular Imaging 9 (10): 1131-1141,2016.

Beer LA, Kossenkov AV, Liu Q, Luning PE, Domchek S, Speicher DW, Ky B: Baseline Immunoglobulin E Levels as a Marker of Doxorubicin- and Trastuzumab-Associated Cardiac Dysfunction. Circulation Research 119 (10): 1135-1144,2016.

Kawut SM, Archer-Chicko CL, DiMichele A, Fritz JS, Klinger JR, Ky B, Palevsky HI, Palmisciano AJ, Patel M, Pinder D, Propert KJ, Smith KA, Stanczyk F, Tracy R, Vaidya A, Whittenhall ME, Ventetuolo CE: Anastrozole in Pulmonary Arterial Hypertension (AIPH): A Randomized, Double-Blind Placebo-Controlled Trial. American Journal of Respiratory and Critical Care Medicine : 2016.

Wang GJ, Shaw PA, Townsend RR, Anderson AH, Xie D, Wang X, Nessel LC, Mohler ER, Sozio SM, Jaar BG, Chen J, Wright J, Taliercio JJ, Ojo A, Ricardo AC, Lustigova E, Fairman RM, Feldman HI, Ky B: The Associations between Peripheral Artery Disease and Physical Outcome Measures in Men and Women with Chronic Kidney Disease. Annals of Vascular Surgery 35 : 111-20,2016.

Armenian SH, Xu L, Ky B, Sun C, Farol L, Pal S, Douglas PS, Bhatia S, Chao C.: Late Occurring Cardiovascular Disease Among Survivors of Adult-Onset Cancer: A Community Based Retrospective Study. Journal of Clinical Oncology 34 (10): 1120-30,2016.

French B, Wang L, Ky B, Fang JC, Sweitzer NK, Cappola TP.: Prognostic value of galectin-3 for adverse outcomes in chronic heart failure. Journal of Cardiac Failure 22 (4): 256-62,2016.

View all publications

Academic Contact Info

Hospital of the University of Pennsylvania
11-105 Smilow Center for Translational Research
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: 215-573-6606
Fax: 215-746-7415
Patient appointments: 800-789-7366 (PENN)

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