Schedule a COVID vaccine or booster appointment:
Log in to myPennMedicine or call us 8am to 5pm, Monday through Friday, at 267-758-4902.
There is no publicly available rating for this medical professional for one of the following reasons:
Sees patients age 18 and up
Sees patients age 18 and up
Perelman Center for Advanced Medicine
South Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
Research Interests Cellular PlasticityPancreatic CancerTumor ImmunologyMetastasisKey words: Metastasis, Pancreatic Cancer, Tumor Immunology, Cell PlasticityDescription of ResearchPancreas CancerPancreatic Ductal Adenocarcinoma (PDAC) is poised to become the second leading cause of cancer death in the United States. This poor outcome is attributable to two facts: (1) pancreatic cancers metastasize early, before clinical detection, and (2) current anti-cancer therapies are inadequate. Our laboratory tackles these problems by understanding how tumors metastasize and identifying vulnerabilities that will lead to better therapies. Our efforts include studies of the tumor microenvironment (including the immune microenvironment), metabolism, cellular plasticity and metastasis biology. We rely on genetically engineered mice that recapitulate salient features of the human disease, functional genomics, epigenetics, and in vitro culture methods that recapitulate the unique microenvironment of the tumor. In addition, we maintain a strong interest in liver plasticity and the pathogenesis of type I diabetes. Rotation ProjectsRotation projects may be available based upon applicant interest. Please contact Dr. Stanger directly to discuss potential projects.Lab personnel:Ben Stanger, MD, PhD - Principal InvestigatorChenghua Yang, MA - Research Specialist, Lab ManagerWill Vostrejs - Research SpecialistAustin Good, MD PhD - Postdoctoral ResearcherMaimon Hubbi, MD PhD - Postdoctoral ResearcherTakeshi Katsuda, PhD – Postdoctoral ResearcherSamantha Kemp, PhD - Postdoctoral ResearcherIl-Kyu Kim, PhD - Postdoctoral Researcher Feiyan Mo, PhD - Postdoctoral ResearchKia Perez-Vale, PhD - Postdoctoral ResearcherMinh Than, MD PhD - Postdoctoral ResearcherErin Hollander - Graduate StudentBenjamin Kahn – Graduate StudentJayne McDevitt - Graduate StudentMargo Orlen - Graduate StudentJane Xie - Graduate StudentCody Eskandarian - Penn UndergraduateRosemary Flock - Penn UndergraduateExecutive Administrator:Fran Tucker firstname.lastname@example.org
Maddipati R, Norgard RJ, Baslan T, Rathi KS, Zhang A, Saeid A, Higashihara T, Wu F, Kumar A, Annamalai V, Bhattacharya S, Raman P, Adkisson CA, Pitarresi JR, Wengyn MD, Yamazoe T, Millstein ID, Bermeo J, Carpenter EL, McAuliffe, Oktay MH, Brekken RA, Lowe SW, lacobuzio-Donahue CA, Notta F, Stanger BZ.: MYC levels regulate metastatic heterogeneity in pancreatic adenocarcinoma Cancer Discov 12 (2): 542-561,2022.
Sela Y, Li J, Maheswaran S, Norgard RJ, Yuan S, Hubbi ME, Doepner M, Xu JP, Ho ES, Mesaros C, Sheehan C, Croley G, Muir A, Blair IA, Shalem O, Dang CV, Stanger BZ: Bcl-xL enforces a slow-cycling state necessary for survival in the nutrient-deprived microenvironment of pancreatic cancer Cancer Res 82 (10): 1890-1908,2022.
Li J, Yuan S, Norgard RJ, Yan F, Sun YH, Kim IK, Merrell AJ, Sela Y, Jiang Y, Bhanu NV, Garcia BA, Vonderheide RH, Blanco A, Stanger BZ.: Epigenetic and Transcriptional Control of the Epidermal Growth Factor Receptor Regulates the Tumor Immune Microenvironment in Pancreatic Cancer Cancer Discov. 11 (3): 736-753,2021.
Kahn BM, Lucas A, Alur RG, Wengyn MD, Schwartz GW, Li J, Sun K, Maurer HC, Olive KP, Faryabi RB, Stanger BZ.: The vascular landscape of human cancer J Clin Invest. 131 (2): e136655,2021.
Norgard RJ, Pitarresi JR, Maddipati R, Aiello-Couzo NM, Balli D, Li J, Yamazoe T, Wengyn MD, Millstein ID, Folkert IW, Rosario-Berrios DN, Kim I-K, Bassett JB, Payne R, Berry CT, Feng X, Sun K, Cioffi M, Chakraborty P, Jolly MK, Gutkind JS, Lyden D, Freedman BD, Foskett JK, Rustgi AK, Stanger BZ.: Calcium signaling induces a partial EMT EMBO Rep. 22 (9): e51872,2021.
Yuan S, Natesan R, Sanchez-Rivera FJ, Li J, Bhanu NV, Yamazoe T, Lin JH, Merrell AJ, Sela Y, Thomas SK, Jiang Y, Plesset JB, Miller EM, Shi J, Garcia BA, Lowe SW, Asangani IA, Stanger BZ: Global regulation of the histone mark H3K36me2 underlies epithelial plasticity and metastatic progression Cancer Discov 10 (6): 854-871,2020.
Li J, Stanger BZ: The tumor as organizer model Science 363 (6431): 1038-1039,2019.
Abramson Family Cancer Research InstituteDivision of GastroenterologyDepartment of MedicineUniversity of Pennsylvania Perelman School of Medicine512 Biomedical Research Bldg II/III (Office)527 Biomedical Research Bldg II/III (Lab)421 Curie Boulevard
Patient appointments: 800-789-7366