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Perelman Center for Advanced Medicine
South Pavilion, 4th Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
Research Interests Cell PlasticityPancreatic CancerTumor ImmunologyMetastasisLiver RegenerationKey words: Metastasis, Pancreatic Cancer, Tumor Immunology, Cell PlasticityDescription of ResearchPancreas CancerPancreatic Ductal Adenocarcinoma (PDA) is poised to become the second leading cause of cancer death in the United States. This poor outcome is attributable to two facts: (1) pancreatic cancers metastasize early, before clinical detection, and (2) current anti-cancer therapies are inadequate. Our laboratory tackles these problems by understanding how tumors metastasize and identifying vulnerabilities that will lead to better therapies. Our efforts include studies of the tumor immune microenvironment, tumor metabolism, and cellular plasticity and metastasis biology. We rely on genetically engineered mice that recapitulate salient features of the human disease, functional genomics, and in vitro culture methods that recapitulate the unique microenvironment of the tumor. In addition, we maintain a strong interest in liver biology and the pathogenesis of type I diabetes. Rotation ProjectsRotation projects may be available based upon applicant interest. Please contact Dr. Stanger directly to discuss potential projects.Lab personnel:Ben Stanger, MD, PhD - Principal InvestigatorChenghua Yang - Research Specialist, Lab ManagerJason Pitarresi, PhD - Research AssociateJason Eccleston, MD - Postdoctoral ResearcherMaimon Hubbi, MD PhD - Postdoctoral ResearcherTakeshi Katsuda, PhD – Postdoctoral ResearcherSamantha Kemp, PhD - Postdoctoral ResearcherIl-Kyu Kim, PhD - Postdoctoral Researcher Yogev Sela, PhD - Postdoctoral ResearcherSalina Yuan - Post-Graduate StudentErin Hollander - Graduate StudentBenjamin Kahn – MD PhD Rotation StudentAdministrative Assistant:Ricardo Tucker (Rico) firstname.lastname@example.org
Yuan S, Natesan R, Sanchez-Rivera FJ, Li J, Bhanu NV, Yamazoe T, Lin JH, Merrell AJ, Sela Y, Thomas SK, Jiang Y, Plesset JB, Miller EM, Shi J, Garcia BA, Lowe SW, Asangani IA, Stanger BZ: Global regulation of the histone mark H3K36me2 underlies epithelial plasticity and metastatic progression Cancer Discov 10 (6): 854-871,2020.
Yuan S, Norgard RJ, Stanger BZ: Cellular Plasticity in Cancer Cancer Discov 9 (7): 837-51,2019.
Li J, Stanger BZ: The tumor as organizer model Science 363 (6431): 1038-1039,2019.
Markosyan N, Li J, Sun YH, Richman LP, Lin JH, Yan F, Quinones L, Sela Y, Yamazoe T, Gordon N, Tobias JW, Byrne KT, Rech AJ, FitzGerald GA, Stanger BZ, Vonderheide RH: Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2) J Clin Invest 130 : 3594-3609,2019.
Aiello NM, Maddipati R, Norgard RJ, Balli D, Li J, Yuan S, Yamazoe T, Black T, Sahmoud A, Furth EE, Bar-Sagi D, Stanger BZ: EMT subtype influences epithelial plasticity and mode of cell migration Developmental Cell 45 (6): 681-695,2018.
Li J, Byrne KT, Yan F, Yamazoe T, Chen Z, Baslan T, Richman LP, Lin J, Sun YH, Rech AJ, Balli D, Hay CA, Sela Y, Merrell AJ, Liudahl SM, Gordon N, Norgard RJ, Yuan S, Yu S, Chao T, Ye S, Eisinger-Mathason TSK, Faryabi RB, Tobias JW, Lowe S, Coussens LM, Wherry EJ, Vonderheide RH, Stanger BZ: Tumor cell-intrinsic factors underlie immune heterogeneity and therapeutic response Immunity 49 (1): 178-193,2018.
Aiello NM, Brabletz T, Kang Y, Nieto MA, Weinberg RA, Stanger BZ: Upholding a role for EMT in pancreatic cancer metastasis Nature 547 (7661): E7-E8,2017.
Abramson Family Cancer Research InstituteDivision of GastroenterologyDepartment of MedicineUniversity of Pennsylvania Perelman School of Medicine512 Biomedical Research Bldg II/III (Office)527 Biomedical Research Bldg II/III (Lab)421 Curie Boulevard
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