Description of Research Expertise:
Key words: Metastasis, Stem Cells, Development, Regeneration, Pancreatic Cancer, Organogenesis
Description of Research
Cell Plasticity in Regeneration and Cancer
During development, cells acquire specialized features through a series of differentiation events. Under normal circumstances, adult cells retain their differentiated identities. However, under a variety of experimental and physiological situations, cell identity can shift. This adult cell plasticity can involve an interchange between adult cellular identities (termed "trans-differentiation") or a reversion from a specialized state to a progenitor stated (termed "de-differentiation"). Our laboratory uses genetically engineered mice to understand how cell identity is maintained in vivo. We study cellular plasticity in the context of liver regeneration, diabetes, and cancer - where epithelial-to-mesenchymal transition promotes cell invasion and metastasis. We believe that the ability to manipulate cellular identity in these settings will facilitate the development of novel therapies for cancer and degenerative disease.
Rotation projects may be available based upon applicant interest. Please contact Dr. Stanger directly to discuss potential projects.
Ben Stanger, MD, PhD - Principal Instigator
Chenghua Yang - Research Specialist, Lab Manager
Ravi Maddipatti, MD - Research Associate
Yi-Ju Chen, PhD - Research Associate
Neha Bhagwat, PhD - Postdoctoral Researcher
Allyson J. Merrell, PhD - Postdoctoral Researcher
Taiji Yamazoe, PhD - Postdoctoral Fellow
Yogev Sela, PhD - Postdoctoral Researcher
Jinyang Li - Graduate Student
Bobby Norgard - Graduate Student
Salina Yuan - Graduate Student
Maddipati R, Stanger BZ: Pancreatic Cancer Metastases Harbor Evidence of Polyclonality Cancer Discov 5 (10): 1086-97,2015.
Penzo-Méndez AI, Chen Y1, Li J, Witze ES, Stanger BZ: Spontaneous Cell Competition in Immortalized Mammalian Cell Lines PLoS One 10 (7): e0132437,2015.
Stanger BZ: Cellular homeostasis and repair in the mammalian liver Annu Rev Physiol 77 : 179-200,2015.
Rhim AD, Oberstein PE, Thomas DH, Mirek ET, Palermo CF, Sastra SA, Dekleva EN, Saunders T, Becerra CP, Tattersall IW, Westphalen CB, Kitajewski J, Fernandez-Berrena MG, Fernandez-Zapico ME, Iacobuzzio-Donahue C, Olive KP*, Stanger BZ*: Stromal elements act to restrain, rather than support, pancreatic ductal adenocarcinoma Cancer Cell 25 (6): 735-747,2014.
Yanger K, Knigin D, Zong Y, Maggs L, Gu G, Akiyama H, Pikarsky E, Stanger BZ: Adult hepatocytes are generated by self-duplication rather than stem-cell differentiation Cell Stem Cell 15 (3): 340-9,2014.
Chen Y-J, Finkbeiner SR, Weinblatt D, Emmett MJ, Tameire F, Yousefi M, Yang C, Maehr R, Zhou Q, Shemer R, Dor Y, Li C, Spence JR, Stanger BZ: De novo formation of insulin-producing “neo-ß-cell islets” from intestinal crypts Cell Reports 6 (6): 1046–58,2014.
Gao T, Zhou D, Yang C, Singh T, Penzo-Mendez A, Maddipati R, Tzatsos A, Bardeesy N, Avruch J, Stanger BZ: Hippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas Gastroenterology 144 (7): 1543-1553,2013 .
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