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Anne R. Cappola, MD, ScM

Anne R. Cappola, MD, ScM Physician

Professor of Medicine

Dr. Cappola is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Diabetes, Endocrinology and Metabolism

Programs & Centers:

Board Certification:

  • Endocrinology, Diabetes, & Metabolism, 1999

Practice Locations and Appointments

  • Penn Endocrinology

    Perelman Center for Advanced Medicine West Pavilion, 4th Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School:
Residency: Brigham and Women's Hospital
Fellowship: Massachusetts General Hospital
Fellowship: Johns Hopkins Hospital


Aging Systems and Geriatrics Study Section, National American Board of Internal Medicine, National American Federation for Medical Research, National American Geriatrics Society, National American Geriatrics Society/National Institute on Aging Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology Workshop, National American Thyroid Association, National American Thyroid Association/National Institute on Aging Thyroid and Aging Research Priorities Workshop, National Association for Patient-Oriented Research, National Board of Scientific Counselors, National Institute of Diabetes, Digestive, and Kidney Diseases, National Cardiovascular Health Study Geriatrics Working Group, National CDC/NCCDPHP Special Emphasis Panel for FOA RFA DP15-002 (Chair), National Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Gerontological Society of America, National National Heart Lung and Blood Institute Workshop, "The Role of Alterations in Thyroid Function in Cardiovascular Disease and the Identification of Early Pathways to Prevention", National National Heart, Blood and Lung Institute CARe Consortium, Aging Working Group, National National Institute on Aging Bedside to Bench Conference, Inflammation and Nutrient Metabolism, National National Institute on Aging Exploratory Workshop, Unexplained Fatigue in the Elderly, National National Institute on Aging Special Emphasis Panel ZAG1 ZIJ-5(M1) Inflammation and Aging, National National Institute on Aging, Biology of the Perimenopause Workshop, National National Institutes of Health Review Panel for GEMSSTAR ZAG1 ZIJ-9 (M1): Grants for Early Medical and Surgical Subspecialists' Transitions to Aging Research, National National Institutes of Health Special Emphasis Panel ZAG1 ZIJ-1 C1 1, National National Institutes of Health Special Emphasis Panel ZAG1 ZIJ-9 C1, National National Institutes of Health Special Emphasis Panel ZRG1 BDA-C 0, National National Institutes of Health Special Emphasis Panel ZRG1 BDCN-W (02) M, National National Scientific Advisory Council for the American Federation for Aging Research, National Philadelphia Endocrine Society, Local The Dunhill Medical Trust, International The Endocrine Society, National Thyroid Studies Collaboration Group, International UK Medical Research Council, International Women in Endocrinology, National Women's Health and Aging Studies, National

Hospital Affiliation

Dr. Cappola is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism; Director of the CTSA-sponsored Center for Human Phenomic Science; and Director of Clinical Research for the Department of Medicine. She is an Associate Editor for the Journal of the American Medical Association (JAMA).

Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies of the indications for treatment of subclinical thyroid dysfunction in older men and women; the role of androgens in the health of older women; hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.

Selected Publications:

Sofer T, Wong Q, Hartwig FP, Taylor K, Warren HR, Evangelou E, Cabrera CP, Levy D, Kramer H, Lange LA, Horta BL, COGENT-BP consortium (includes Cappola A), Kerr KF, Reiner AP: Genome-wide association study of blood pressure traits by Hispanic/latino background: the Hispanic Community Health Study/Study of Latinos Sci Rep 7 (1): 10438,2017.

Aubert CE, Floriani C, Bauer DC, da Costa BR, Segna D, Blum MR, Collet TH, Fink HA, Cappola AR, Syrogiannouli L, Peeters RP, Åsvold BO, den Elzen WP, Luben RN, Bremner AP, Gogakos A, Eastell R, Kearney PM, Hoff M, Le Blanc E, Ceresini G, Rivadeneira F, Uitterlinden AG, Khaw KT, Langhammer A, Stott DJ, Westendorp RG, Ferrucci L, Williams GR, Gussekloo J, Walsh JP, Augjesky D: Thyroid function tests in the reference range and fracture: individual participant analysis of prospective cohorts J Clin Endocrinol Metab 102 (8): 2719-2728,2017.

Chaker L, Korevaar TIM, Rizopoulos D, Collet TH, Völzke H, Hofman A, Rodondi N, Cappola AR, Peeters RP: Defining optimal health range for thyroid function based on the risk of cardiovascular disease J Clin Endocrinol Metab 102 (8): 2853-2861,2017.

Liang J, Le TH, Edwards DRV, Tayo BO, Gaulton KJ, Smith JA, Lu Y, Jensen RA, Chen G, Yanek LR, Schwander K, Tajuddin SM, Sofer T, Kim W, Kayima J, McKenzie CA, Fox E, Nalls MA, Young JH, Sun YV, Lane JM, Cechova S, Zhou J, Tang H, Fornage M, Musani SK, Wang H, Lee J, Adeyemo A, Dreisbach AW, Forrester T, Chu PL, Cappola A, Evans MK, Morrison AC, Martin LW, Wiggins KL, Hui Q, Zhao W, Jackson RD, Ware EB, Faul JD, Reiner AP, Bray M, Denny JC, Mosley TH, Palmas W, Guo X, Papanicolaou GJ, Penman AD, Polak JF: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in African-ancestry populations PLoS Genet 13 (5): e1006728,2017.

Koenig AM, Mechanic-Hamilton D, Xie SX, Combs MF, Cappola AR, Xie L, Detre JA, Wolk DA: Effects of the insulin sensitizer metformin in Alzheimer Disease: pilot data from a randomized placebo-controlled crossover study Alzheimer Dis Assoc Disord 31 (2): 107-113,2017.

Kaplan RC, Strizich G, Aneke-Nash C, Dominguez-Islas C, Buzkova P, Strickler H, Rohan T, Pollak M, Kuller L, Kizer JR, Cappola A, Li CI, Psaty BM: Insulinlike growth factor binding protein-1 and ghrelin predict health outcomes among older adults: CHS cohort J Clin Endocrinol Metab 102 (1): 267-278,2017.

Segna D, Bauer DC, Feller M, Schneider C, Fink H, Aubert C, Collet TH, da Costa B, Fischer K, Peeters R, Cappola A, Blum M, van Dorland H, Robbins J, Naylor K, Eastell R, Uitterlinde A, Rivadeneira F, Gussekloo J: Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts J Intern Med : 2017.

Aneke-Nash CS, Xue X, Qi Q, Biggs ML, Cappola A, Kuller L, Pollak M, Psaty BM, Siscovick D, Mukamal K, Strickler HD: The association between IGF-1 and IGFPB-3 and incident diabetes in an older population of men and women in the Cardiovascular Health Study J Clin Endocrinol Metab : 2017.

Sanders JL, Guo W, O’Meara ES, Kaplan RC, Pollak MN, Bartz TM, Newman AB, Fried LP: Trajectories of IGF-I predict mortality in older adults: the Cardiovascular Health Study J Gerontol A Biol Sci Med Sci : 2017.

Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, Cappola AR, Heckbert SR, Ceresini G, Gussekloo J, den Elzen W, Peeters RP, Luben R, Volzke H, Door M, Walksh JP, Bremner A, Iacoviello M, Macfarlane P, Heering J, Stott DJ, Westendorp R, Khaw KT, Magnani J, Aujesky D: Thyroid function within the normal range, subclinical hypothyroidism, and the risk of atrial fibrillation Circulation : 2017.

View all publications

Academic Contact Info

Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421

Philadelphia, PA 19104-5160
Phone: (215) 746-6391
Patient appointments: 800-789-7366 (PENN)

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