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Anne R. Cappola, MD, ScM

Anne R. Cappola, MD, ScM Physician

Professor of Medicine Professor Professor

Dr. Cappola is employed by Penn Medicine.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

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Clinical Specialties


  • Diabetes, Endocrinology and Metabolism

Programs & Centers:

Board Certification:

  • Endocrinology, Diabetes, & Metabolism, 1999

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Brigham and Women's Hospital
Fellowship: Massachusetts General Hospital
Fellowship: Johns Hopkins Hospital


American Board of Internal Medicine, National American Thyroid Association, National Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Gerontological Society of America, National National Institutes of Health Review Panel for GEMSSTAR ZAG1 ZIJ-9 (M1): Grants for Early Medical and Surgical Subspecialists' Transitions to Aging Research, National National Scientific Advisory Council for the American Federation for Aging Research, National Philadelphia Endocrine Society, Local The Endocrine Society, National Thyroid Studies Collaboration Group, International Women in Endocrinology, National Women's Health and Aging Studies, National

Hospital Affiliation

Dr. Cappola is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism; Director of the CTSA-sponsored Center for Human Phenomic Science; and Director of Clinical Research for the Department of Medicine. She is an Associate Editor for the Journal of the American Medical Association (JAMA).

Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies of the indications for treatment of subclinical thyroid dysfunction in older men and women; the role of androgens in the health of older women; hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.

Selected Publications:

Segna D, Bauer DC, Feller M, Schneider C, Fink HA, Aubert CE, Collet TH, da Costa BR, Fischer K, Peeters RP, Cappola AR, Blum MR, van Dorland HA, Robbins J, Naylor K, Eastell R, Uitterlinden AG, Rivadeneira Ramierez F, Gogakos A, Gussekloo J, Williams GR, Schwartz A, Cauley JA, Aujesky DA, Bischoff-Ferrari HA, Rodondi N; Thyroid Studies Collaboration: Association between subclinical thyroid dysfunction and change in bone mineral density in prospective cohorts J Intern Med 283 (1): 56-72,2018.

Peterson SJ, Cappola AR, Castro MR, Dayan CM, Farwell AP, Hennessey JV, Kopp PA, Ross DS, Samuels MH, Sawka AM, Taylor PN, Jonklaas J, Bianco AC: An online survey of hypothyroid patients demonstrates prominent dissatisfaction Thyroid : 2018.

Sanders JL, Guo W, O’Meara ES, Kaplan RC, Pollak MN, Bartz TM, Newman AB, Fried LP, Cappola AR: Trajectories of IGF-I predict mortality in older adults: the Cardiovascular Health Study J Gerontol A Biol Sci Med Sci : 2018.

Gannon AW, Langer JE, Bellah R, Ratcliffe S, Pizza J, Mostoufi-Moab S, Cappola AR, Bauer AJ: Diagnostic accuracy of ultrasound with color flow Doppler in children with thyroid nodules J Clin Endocrinol Metab : 2018.

Sanders JL, Arnold AM, Boudreau RM, Hirsch CH, Kizer JR, Kaplan RC, Cappola AR, Cushman M, Jacob ME, Kritchevsky SB, Newman AB: Association of biomarker and physiologic indices with mortality in older adults: Cardiovascular Health Study J Gerontol Med Sci : 2018.

Aneke-Nash CS, Xue X, Qi Q, Biggs ML, Cappola A, Kuller L, Pollak M, Psaty BM, Siscovick D, Mukamal K, Strickler HD, Kaplan RC: The association between IGF-1 and IGFPB-3 and incident diabetes in an older population of men and women in the Cardiovascular Health Study J Clin Endocrinol Metab 102 (12): 4541-4547,2017.

Baumgartner C, da Costa BR, Collet TH, Feller M, Floriani C, Bauer DC, Cappola AR, Heckbert SR, Ceresini G, Gussekloo J, den Elzen W, Peeters RP, Luben R, Volzke H, Door M, Walksh JP, Bremner A, Iacoviello M, Macfarlane P, Heering J, Stott DJ, Westendorp R, Khaw KT, Magnani J, Aujesky D, Rodondi N for the Thyroid Studies Collaboration: Thyroid function within the normal range, subclinical hypothyroidism, and the risk of atrial fibrillation Circulation 136 (22): 2100-2116,2017.

Sofer T, Wong Q, Hartwig FP, Taylor K, Warren HR, Evangelou E, Cabrera CP, Levy D, Kramer H, Lange LA, Horta BL, COGENT-BP consortium (includes Cappola A), Kerr KF, Reiner AP, Franceschini N: Genome-wide association study of blood pressure traits by Hispanic/latino background: the Hispanic Community Health Study/Study of Latinos Sci Rep 7 (1): 10438,2017.

Aubert CE, Floriani C, Bauer DC, da Costa BR, Segna D, Blum MR, Collet TH, Fink HA, Cappola AR, Syrogiannouli L, Peeters RP, Åsvold BO, den Elzen WP, Luben RN, Bremner AP, Gogakos A, Eastell R, Kearney PM, Hoff M, Le Blanc E, Ceresini G, Rivadeneira F, Uitterlinden AG, Khaw KT, Langhammer A, Stott DJ, Westendorp RG, Ferrucci L, Williams GR, Gussekloo J, Walsh JP, Augjesky D, Rodondi N for the Thyroid Studies Collaboration: Thyroid function tests in the reference range and fracture: individual participant analysis of prospective cohorts J Clin Endocrinol Metab 102 (8): 2719-2728,2017.

Chaker L, Korevaar TIM, Rizopoulos D, Collet TH, Völzke H, Hofman A, Rodondi N, Cappola AR, Peeters RP, Franco OH: Defining optimal health range for thyroid function based on the risk of cardiovascular disease J Clin Endocrinol Metab 102 (8): 2853-2861,2017.

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Academic Contact Info

Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421

Philadelphia, PA 19104-5160
Phone: (215) 746-6391
Patient appointments: 800-789-7366 (PENN)

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