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Anne R. Cappola, MD, ScM

Anne R. Cappola, MD, ScM Physician

Professor of Medicine

Dr. Cappola is a Penn Medicine employed physician.

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Diabetes, Endocrinology and Metabolism

Programs & Centers:

Board Certification:

  • Endocrinology, Diabetes, & Metabolism, 1999

Practice Locations and Appointments

  • Penn Endocrinology

    Perelman Center for Advanced Medicine West Pavilion, 4th Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Pennsylvania School of Medicine
Residency: Brigham and Women's Hospital
Fellowship: Massachusetts General Hospital
Fellowship: Johns Hopkins Hospital


Aging Systems and Geriatrics Study Section, National American Board of Internal Medicine, National American Federation for Medical Research, National American Geriatrics Society, National American Geriatrics Society/National Institute on Aging Research Agenda for Frailty in Older Adults: Toward a Better Understanding of Physiology and Etiology Workshop, National American Thyroid Association, National American Thyroid Association/National Institute on Aging Thyroid and Aging Research Priorities Workshop, National Association for Patient-Oriented Research, National Board of Scientific Counselors, National Institute of Diabetes, Digestive, and Kidney Diseases, National Cardiovascular Health Study Geriatrics Working Group, National CDC/NCCDPHP Special Emphasis Panel for FOA RFA DP15-002 (Chair), National Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, International Gerontological Society of America, National National Heart Lung and Blood Institute Workshop, Thyroid and the Heart, National National Heart, Blood and Lung Institute CARe Consortium, Aging Working Group, National National Institute on Aging Bedside to Bench Conference, Inflammation and Nutrient Metabolism, National National Institute on Aging Exploratory Workshop, Unexplained Fatigue in the Elderly, National National Institute on Aging Special Emphasis Panel ZAG1 ZIJ-5(M1) Inflammation and Aging, National National Institute on Aging, Biology of the Perimenopause Workshop, National National Institutes of Health Review Panel for GEMSSTAR ZAG1 ZIJ-9 (M1): Grants for Early Medical and Surgical Subspecialists' Transitions to Aging Research, National National Institutes of Health Special Emphasis Panel ZAG1 ZIJ-1 C1 1, National National Institutes of Health Special Emphasis Panel ZAG1 ZIJ-9 C1, National National Institutes of Health Special Emphasis Panel ZRG1 BDA-C 0, National National Institutes of Health Special Emphasis Panel ZRG1 BDCN-W (02) M, National National Scientific Advisory Council for the American Federation for Aging Research, National Philadelphia Endocrine Society, Local The Dunhill Medical Trust, International The Endocrine Society, National Thyroid Studies Collaboration Group, International Women in Endocrinology, National Women's Health and Aging Studies, National

Hospital Affiliation

Dr. Cappola is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Anne Rentoumis Cappola, M.D., Sc.M. is a Professor of Medicine in the Division of Endocrinology, Diabetes, and Metabolism; Director of the CTSA-sponsored Center for Human Phenomic Science; and Director of Clinical Research for the Department of Medicine. She is an Associate Editor for the Journal of the American Medical Association (JAMA).

Dr. Cappola leads an NIH-funded program focusing on the hormonal alterations that occur with aging and the clinical impact of these changes Current projects include studies of the indications for treatment of subclinical thyroid dysfunction in older men and women; the role of androgens in the health of older women; hormonal treatments for the frailty syndrome; and metabolic changes in men and women who sustain a hip fracture.

Selected Publications:

Kaplan RC, Strizich G, Aneke-Nash C, Dominguez-Islas C, Buzkova P, Strickler H, Rohan T, Pollak M, Kuller L, Kizer JR, Cappola A, Li CI, Psaty BM, Newman A: Insulinlike growth factor binding protein-1 and ghrelin predict health outcomes among older adults: CHS cohort J Clin Endocrinol Metab 102 (1): 267-278,2017.

Chaker L, Baumgartner C, den Elzen WP, Collet TH, Ikram MA, Blum MR, Dehghan A, Drechsler C, Luben RN, Portegies ML, Iervasi G, Medici M, Stott DJ, Dullaart RP, Ford I, Bremner A, Newman AB, Wanner C, Sgarbi JA, Dörr M, Longstreth WT Jr, Psaty BM, Ferrucci L, Maciel RM, Westendorp RG, Jukema JW, Ceresini G, Imaizumi M, Hofman A, Bakker SJ, Franklyn JA, Khaw KT, Bauer DC, Walsh JP, Razvi S, Gussekloo J, Völzke H, Franco OH, Cappola AR, Rodondi N, Peeters RP, for the Thyroid Studies Collaboration: Thyroid function within the reference range and the risk of stroke: an individual participant data analysis. J Clin Endocrinol Metab 101 (11): 4270-4282,2016.

Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, Berndt SI, Bidlingmaier M, Broer L; CHARGE Longevity Working Group, Cappola A, Ceda GP, Chanock S, Chen MH, Chen TC, Chen YD, Chung J, Del Greco Miglianico F, Eriksson J, Ferrucci L, Friedrich N, Gnewuch C, Goodarzi MO, Grarup N, Guo T, Hammer E, Hayes RB, Hicks AA, Hofman A, Houwing-Duistermaat JJ, Hu F, Hunter DJ, Husemoen LL, Isaacs A, Jacobs KB, Janssen JA, Jansson JO, Jehmlich N, Johnson S, Juul A, Karlsson M, Kilpelainen TO, Kovacs P, Kr: Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits Aging Cell 15 (5): 811-24,2016.

Maggio M, de Vita F, Lauretani F, Bandinelli S, Semba RD, Bartali B, Cherubini A, Cappola AR, Ceda GP, Ferrucci L: Relationship between carotenoids, retinol, and estradiol levels in older women Nutrients 7 (8): 6506-19,2015.

Åsvold BO, Vatten LJ, Bjøro T, Bauer DC, Bremner A, Cappola AR, Ceresini G, den Elzen WPJ, Ferrucci L, Franco OH, Franklyn JA, Gussekloo J, Iervasi G Imaizumi M, Kearney PM, Khaw KT, Newman AB, Peeters RP, Psaty BM, Razvi S, Sgarbi JA, Stott DK, Trompet S, Vanderpump MP, Völzke H, Walsh JP, Westendorp RG, Rodondi N, for the Thyroid Studies Collaboration: Thyroid function within the normal range and risk of coronary heart disease JAMA-Internal Medicine 175 (6): 1037-47,2015.

Chaker L, Baumgartner C, den Elzen W, Ikram, MA, Blum MR, Collet TH, Bakker SJ, Dehgha A, Drechsler C, Luben RN, Hofman A, Portegies ML, Medici M, Iervasi G, Stott DJ, Ford I, Bremner A, Wanner C, Ferrucci L, Newman A, Dullaart RP, Sgarbi JA, Ceresini G, Maciel RM, Westendorp R, Jukema JW, Imaizumi M, Franklyn JA, Bauer DC, Walsh JP, Rasvi S, Khaw KT, Cappola AR, Völzke H, Franco OH, Gussekloo J, Rodondi N, Peeters RP: Subclinical hypothyroidism and the risk of stroke events and fatal stroke: an individual participant data analysis J Clin Endocrinol Metab 100 (6): 2181-91,2015.

Blum MR, Bauer DC, Collet TH, Fink HA, Cappola AR, da Costa BR, Wirth CD, Peeters RP, Åsvold BO, den Elzen WP, Luben RN, Imaizumi M, Bremner AP, Gogakos A, Eastell R, Kearney PM, Strotmeyer ES, Wallace ER, Hoff M, Ceresini G, Rivadeneira F, Uitterlinden AG, Stott DJ, Westendorp RG, Khaw KT, Langhammer A, Ferrucci L, Gussekloo J, Williams GR, Walsh JP, Jüni P, Aujesky D, Rodondi N for the Thyroid Studies Collaboration: Subclinical thyroid dysfunction and fracture risk: a meta-analysis JAMA 313 (20): 2055-65,2015.

Cappola AR, Arnold AM, Wulczyn K, Carlson M, Robbins J, Psaty BM: Thyroid function in the euthyroid range and adverse outcomes in older adults J Clin Endocrinol Metab 100 (3): 1088-96,2015.

Corriere MD, Yao W, Xue QL, Cappola AR, Fried LP, Thorpe RJ, Szanton SL, Kalyani RR : The association of neighborhood characteristics with obesity and metabolic conditions in older women JNHA 18 (9): 792-8,2014.

Maggio M, Snyder PJ, De Vita F, Ceda GP, Milaneschi Y, Lauretani F, Luci M, Cattabiani C, Peachey H, Valenti G, Cappola AR, Longo DL, Ferrucci L: Effects of transdermal testosterone treatment on inflammatory markers in elderly men Endocr Pract 20 (11): 1170-7,2014.

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Academic Contact Info

Division of Endocrinology, Diabetes, and Metabolism
Room 12-136
Smilow Center for Translational Research, 12th floor
3400 Civic Center Blvd., Building 421

Philadelphia, PA 19104-5160
Phone: (215) 573-5359
Fax: (215) 898-5408
Patient appointments: 800-789-7366 (PENN)

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