Penn Medicine Provider
Medical Oncology
Angela DeMichele, MD, MSCE
5.0
(214)
Accepting new patients
Sees patients age 18 and up
Rena Rowan Breast Center

About me

  • Co-Leader, Breast Cancer Research Program
  • Co-Director, 2-PREVENT Breast Cancer Translational Center of Excellence
  • Mariann T. and Robert J. MacDonald Professor in Breast Cancer Care Excellence

Dr. DeMichele specializes in developing new therapies for breast cancer, neoadjuvant therapy  and preventing breast cancer recurrence.

Co-Chair of the ECOG/ACRIN Cooperative Group Breast Committee; Chair, Trial Operations Working Group, I-SPY Consortium; Member of the NCI Breast Cancer Steering Committee

Education and training

  • Medical School: Washington University in St. Louis
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: University of Bologna School of Medicine
  • Fellowship: Hospital of the University of Pennsylvania

What my patients think about me

Average Rating
5.0

214 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

May 2025
5.0
5.0
she's a great doctor
May 2025
5.0
5.0
knowledgeable and caring
April 2025
5.0
5.0
very knowledgeable and warm
April 2025
5.0
5.0
dr is very person able also very competent and good..excudes confidence

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. DeMichele is a Penn Medicine physician.

Qualifications and experience

My research

Shinn, E., Zahrieh, D., DeMichele, A., Zdenkowski, N., Lemieux, J., Mao, J., Bjelic-Radisic, V., Naughton, M. J., Pfeiler, G., Gelmon, K., Balko, J. M., Egle, D., Zoppoli, G., Traina, T., Jimenez, M. M., Novoa, S. A., Haddad, T., Chan, A., Ring, A., Wolff, A., Symanns, W. F., Lorenzo, J. P., Sabanatha, D., Burstein. H. J., Bellet-Ezquerra, M., Foukakis, T., Novik, Y., Rubovszky, G., Singer, C. F., Muehlbacher, K., Filho, O. M., Goulioti, T., Law, E., Partridge, A. H., Carey, L. A., Zoroufy, A., Hlauschek, D., Fesl, C., Mayer, E. L., Gnant, M. Impact of adding palbociclib on treatment adherence to ongoing adjuvant endocrine treatment in the global randomized PALLAS randomized trial in patients with early breast cancer , Breast Cancer Res Treat: 2025


Hahnen, E., Hauke, J., Gelmon, K., Marmé, F., Ernst, C., Martin, M., Untch, M., Bonnefoi, H., Knudsen, E., Im, S.-A., DeMichele, A., Van’t Veer, L., Kim, S.-B., Bear, H., McCarthy, N., Rhiem, K., Turner, N., Witkiewicz, A., Rojo, F., Filipits, M., Martin, LA., Fasching, P. A., Schem, C., Becker, K., García-Sáenz, J. A., Kelly, C. M., Reimer, T., Toi, M., Rugo, H. S., Denkert, C., Gnant, M., Makris, A., Liu, Y., Valota, O., Felder, B., Weber, K., Nekljudova, V., Loibl, S. BRCA1/2 and Other Predisposition Genes in High-Risk Hormone Receptor+/Human Epidermal Growth Factor Receptor 2- Breast Cancer Treated With Endocrine Therapy With or Without Palbociclib: A Secondary PENELOPE-B Study Analysis , JCO Precision Oncology: 2025


Thomas, A., Mayer, E. L., DeMichele, A., Harbeck, N., Curigliano, G., Ignatiadis, M., Adam, V., Zhou, Y., Brown, T. P., Gilham, L., Chua, B. H., Kalinsky, K., Wolff, A. C., & O'Reilly, S. Further Optimizing Care of Patients With Operable Hormone Receptor-Sensitive Breast Cancer , J Clin Oncol: 2025


Denkert C, Rachakonda S, Karn T, Weber K, Martin M, Marmé F, Untch M, Bonnefoi H, Kim S, Seiler S, Bear HD, Witkiewicz AK, Im S, DeMichele A, Pehl A, Van't Veer L, McCarthy N, Stiewe T, Jank P, Gelmon KA, García-Sáenz JA, Westhoff CC, Kelly CM, Reimer T, Felder B, Olivé MM, Knudsen ES, Turner N, Rojo F, Schmitt WD, Fasching PA, Teply-Szymanski J, Zhang Z, Toi M, Rugo HS, Gnant M, Makris A, Holtschmidt J, Nekljudova V, Loibl S Dynamics of molecular heterogeneity in high-risk luminal breast cancer—From intrinsic to adaptive subtyping , Cancer Cell: 2025


Huppert, L. A., Wolf, D., Yau, C., Brown-Swigart, L., Hirst, G. L., Isaacs, C., Pusztai, L., Pohlmann, P. R., DeMichele, A., Shatsky, R., Yee, D., Thomas, A., Nanda, R., Perlmutter, J., Heditsian, D., Hylton, N., Symmans, F., Van't Veer, L. J., Esserman, L., & Rugo, H. S. Pathologic complete response (pCR) rates for patients with HR+/HER2- high-risk, early-stage breast cancer (EBC) by clinical and molecular features in the phase II I-SPY2 clinical trial , Annals of Oncology: 2025


Li, W., Onishi, N., Gibbs, J. E., Wilmes, L. J., Le, N. N., Metanat, P., Price, E. R., Joe, B. N., Kornak, J., Yau, C., Wolf, D. M., Magbanua, M. J. M., LeStage, B., van 't Veer, L. J., DeMichele, A. M., Esserman, L. J., & Hylton, N. M. MRI-Based Model for Personalizing Neoadjuvant Treatment in Breast Cancer , Tomography: 2025


Mukhtar, R. A., Gottipati, S., Yau, C., López-Tarruella, S., Earl, H., Hayward, L., Hiller, L., Osdoit, M., van der Noordaa, M., de Croze, D., Hamy, A. S., Laé, M., Reyal, F., Sonke, G. S., Steenbruggen, T. G., van Seijen, M., Wesseling, J., Martín, M., Del Monte-Millán, M., Boughey, J. C., Goetz, M. P., Hoskin, T., Valero, V. Edge, S. B., Abraham, J. E., Bartlett, J. M. S., Caldas, C., Dunn, J., Provenzano, E., Sammut, S. J., Thomas, J. S., Graham, A., Hall, P., Mackintosh, L., Fan, F., Godwin, A. K., Schwensen, K., Sharma, P., DeMichele, A. M., Cole, K., Pusztai, L., Kim, M., van 't Veer, L. J., Cameron, D., Laura J Esserman, L. J., Fraser Symmans, W. A pooled analysis evaluating prognostic significance of Residual Cancer Burden in invasive lobular breast cancer , NPJ Breast Cancer: 2025


O'Hara, M. H., Jegede, O., Dickson, M. A., DeMichele, A. M., Piekarz, R., Gray, R. J., Wang, V., McShane, L. M., Rubinstein, L. V., Patton, D. R., Williams, P. M., Hamilton, S. R., Onitilo, A., Tricoli, J. V., Conley, B. A., Arteaga, C. L., Harris, L. N., O'Dwyer, P. J., Chen, A. P., & Flaherty, K. T. Phase II Study of Palbociclib in Patients with Tumors with CDK4 or CDK6 Amplification: Results from the NCI-MATCH ECOG-ACRIN Trial (EAY131) Subprotocol Z1C , Clin Cancer Res: 2025


Rugo, H. S., Campbell, M., Yau, C., Jo Chien, A., Wallace, A. M., Isaacs, C., Boughey, J. C., Han, H. S., Buxton, M., Clennell, J. L., Asare, S. M., Steeg, K., Wilson, A., Singhrao, R., Matthews, J. B., Perlmutter, J., Fraser Symmans, W., Hylton, N. M., DeMichele, A. M., Yee, D., Van't Veer, L. J., Berry, D. A., Esserman, L. J. Pexidartinib and standard neoadjuvant therapy in the adaptively randomized I-SPY2 trial for early breast cancer , Breast Cancer Res Treat : 2024


Young, A. J., Pantel, A. R., Kiani, M., Doot, R. K., Bagheri, S., Pryma, D. A., Farwell, M. D., Li, S., Lee, H., Schubert, E. K., Secreto, A., Zuckerman, S. P., Nayak, A., Choi, H., Carlin, S., DeMichele, A., Mankoff, D. A., Zhou, R., Mach, R. H., & McDonald, E. S. Kinetic Analysis and Metabolism of Poly(Adenosine Diphosphate-Ribose) Polymerase-1-Targeted 18F-Fluorthanatrace PET in Breast Cancer , J Nucl Med: 2024