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Angela DeMichele, MD, MSCE

Angela DeMichele, MD, MSCE Physician

Co-Leader, Breast Cancer Research Program Director, Breast Cancer Clinical Trials Unit Alan and Jill Miller Professor in Breast Cancer Excellence

Dr. DeMichele is employed by Penn Medicine.

About Dr. Angela DeMichele

Recognized by America's Top Doctors for 2017

Recognized in Philadelphia magazine's annual Top Docs issues for 2018 and 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Medical Oncology

Programs & Centers:

Board Certification:

  • Medical Oncology, 1998

Clinical Expertise:

  • Breast Cancer
  • Inflammatory Breast Cancer (IBC)
  • Male Breast Cancer
  • Triple-Negative Breast Cancer

Practice Locations and Appointments

  • Rena Rowan Breast Center

    Abramson Cancer Center Perelman Center for Advanced Medicine, West Pavilion, 3rd Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: Washington University
Residency: Hospital of the University of Pennsylvania
Fellowship: University of Bologna School of Medicine
Fellowship: Hospital of the University of Pennsylvania


American Association of Cancer Research (AACR), National American Board of Internal Medicine (ABIM), National American College of Epidemiology, National American College of Physicians, National American Society of Breast Disease, National American Society of Clinical Oncology (ASCO), National Living Beyond Breast Cancer, National National Comprehensive Cancer Network (NCCN), National

Hospital Affiliation

Dr. DeMichele is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.


Description of Research Expertise:

breast cancer, biomarkers, clinical trials, pharmacogenetics, cytokines, host immunogenetics, cancer survivorship, molecular epidemiology

Selected Publications:

Schmitz KH, Troxel, AB, Dean LT, DeMichele A, Brown JC, Sturgeon K, Zhang Z, Evangelisti M, Spinelli B, Kallan MJ, Denlinger C, Cheville A, Winkels RM, Chodosh L, Sarwer DB: Effect of Home-Based Exercise and Weight Loss Programs on Breast Cancer–Related Lymphedema Outcomes Among Overweight Breast Cancer Survivors JAMA Oncology : 2019.

Clark AS, McAndrew NP, Troxel A, Feldman M, Lal P, Rosen M, Burrell J, Redlinger C, Gallgher M, Bradbury AR, Domchek SM, Fox KR, O'Dwyer PJ, DeMichele, AM: Combination Paclitaxel and Palbociclib: Results of a Phase I Trial in Advanced Breast Cancer Clinical Cancer Research Epub ahead of print : 2019.

Nanda R, Liu M, Yau C, Shatsky R, Pusztai L, Wallace A, Chien JA, Forero-Torres A, Ellis E, Han H, Clark AS, Albain K, Boughey J, Jaskowiak N, Elias A, Isaacas C, Kemmer K, Helsten T, Maure M, Stinger-Reasor E, Parker C, Lee M, Haddad T, Cohen R, Asare S, Wilson A, Hirst G, Singhrao R, Asare A, Matthews J, Berry S, Schwab R, Symmans W, van't Veer L, Yee D, DeMichele A, Hylton N, Oerlmutter J, Rugo H, Berry D, Esserman L: Pembrolizumab for Early-Stage, High-Risk, HER2-Negative Breast Cancer: Results from the I-SPY2 Trial New England Journal of Medicine : 2019.

Demissei BG, Finkelman B, Hubbard RA, Zhang L, Smith AM, Sheline K, McDonald C, Narayan HK, Narayan V, Waxman AJ, Domchek SM, DeMichele A, Shah P, Clark AS, Bradbury A, Carver JR, Upshaw J, Armenian SH, Liu P, Ky B: Detailed phenotyping reveals distinct trajectories of cardiovascular function and symptoms with exposure to modern breast cancer therapy Cancer In press : 2019.

Lynch HF, Largent EA, Joffe S, DeMichele AM: Protecting clinical trial participants and study integrity in the age of social media Cancer 124 (24): 4610-4617,2018.

Maity A, Mick R, Huang AC, George SM, Farwell MD, Lukens JN, Berman AT, Mitchell TC, Bauml J, Schuchter LM, O'Hara M, Lin LL, Demichele A, Christodouleas, JP, Haas NB, Patsch DM, Hahn SM, Minn AJ, Wherry EJ, Vonderheide RH: A phase I trial of pembrolizumab with hypofractionated radiotherapy in patients with metastatic solid tumours British Journal of Cancer 119 (10): 2018.

Turner NC, Slamon DJ, Ro J, Bondarenko I, Im SA, Masuda N, Colleoni M, DeMichele A, Loi S, Verma S, Iwata H, Harbeck N, Loibl S, André F, Puyana Theall, K, Huang X, Giorgetti C, Huang Bartlett C, Cristofanilli M: Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer New England Journal of Medicine 379 (20): 2018.

Cristofanilli M, DeMichele A, Giorgetti C, Turner NC, Slamon DJ, Im SA, Masuda, N, Verma S, Loi S, Colleoni M, Theall KP, Huang X, Liu Y, Bartlett CH: Predictors of prolonged benefit from palbociclib plus fulvestrant in women with endocrine-resistant hormone receptor-positive/human epidermal growth factor receptor 2-negative metastatic breast cancer in PALOMA-3 European Journal of Cancer 104 : 21-31,2018.

O'Shaughnessy Joyce, DeMichele Angela, Ma Cynthia X, Richards Paul, Yardley Denise A, Wright Gail Shaw, Kalinsky Kevin, Steis Ronald, Diab Sami, Kennealey Gerard, Geschwindt Ryan, Jiang Wei, Rugo Hope S: A randomized, double-blind, phase 2 study of ruxolitinib or placebo in combination with capecitabine in patients with advanced HER2-negative breast cancer and elevated C-reactive protein, a marker of systemic inflammation. Breast cancer research and treatment 170 (3): 547-557,2018.

Banerjee Sagarika, Tian Tian, Wei Zhi, Shih Natalie, Feldman Michael D, Peck Kristen N, DeMichele Angela M, Alwine James C, Robertson Erle S: Distinct Microbial Signatures Associated With Different Breast Cancer Types. Frontiers in microbiology 9 : 951,2018.

Academic Contact Info

Division of Hematology Oncology
Perelman Center for Advanced Medicine
10th Floor, South Pavilion
Office #10-153
3400 Civic Center Boulevard

Philadelphia, PA 19104
Phone: (215) 349-5730
Patient appointments: 800-789-7366 (PENN)

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