Description of Research Expertise

1. Medical Education - Involvement in all aspects of medical training at Penn School of Medicine and Penn Graduate Medical Education. Areas of expertise include novel curriculum development including enhanced multidisciplinary teaching in palliative care, critical care, and glomerular diseases. Additional efforts have focused on increasing minority trainee representation within nephrology.
2. Kidney living donor evaluation and outcomes - Expansion of non-directed donation through collaboration with the National Kidney Registry. Quality improvement efforts for more streamlined and donor-centered care approaches, leading to improved donor experience and improved efficiency of living donor evaluation processes.
3. Influence of dietary patterns and CKD management - This area of research includes the association of micronutrient content and clinical outcomes in chronic kidney disease and healthy individuals. She is interested in the clinical outcomes associated with potassium, sodium, and the ratio of these two electrolytes in terms of cardiovascular and kidney disease clinical outcomes and has published in this area.
4. Contrast associated acute kidney injury - Involvement in both scholarly activity and quality improvement of assessment and management of IV contrast nephrotoxicity.

Selected Publications

Spiardi R, Shah S, Leonberg-Yoo A.: A Patient With Polyuria and Hypercalcemia Am J Kidney Dis 79 (4): A14-A15,2022.

Jezmir JL, Bharadwaj M, Chaitoff A, Diephuis B, Crowley CP, Kishore SP, Goralnick E, Merriam LT, Milliken A, Rhee C, Sadovnikoff N, Shah SB, Gupta S, Leaf DE, Feldman WB, Kim EY; STOP-COVID Investigators.: Performance of crisis standards of care guidelines in a cohort of critically ill COVID-19 patients in the United States Cell Rep Med 2 : 100376,2021.

Gelfand SL, Jain K, Brewster UC, Leonberg-Yoo AK.: Combined Nephrology and Palliative Medicine Fellowship Training: A Breath of Fresh AIRE Am J Kidney Dis S0272-6386 (21): 00881-7,2021.

Mathews KS, Soh H, Shaefi S, Wang W, Bose S, Coca S, Gupta S, Hayek SS, Srivastava A, Brenner SK, Radbel J, Green A, Sutherland A, Leonberg-Yoo A, Shehata A, Schenck EJ, Short SAP, Hernán MA, Chan L, Leaf DE; Study of the Treatment and Outcomes in Critically Ill Patients with Coronavirus Disease (STOP-COVID) Investigators.: Prone Positioning and Survival in Mechanically Ventilated Patients With Coronavirus Disease 2019-Related Respiratory Failure Crit Care Med : 1026-1037,2021.

Bansal N, Hall YN, Sambandam KK, Leonberg-Yoo AK.: Lessons Learned: Nephrology Training Program Adaptation in the Time of COVID Am J Kidney Dis 78 (1): 9-12,2021.

Rudnick MR, Wahba IM, Leonberg-Yoo AK, Miskulin D, Litt HI.: Risks and Options With Gadolinium-Based Contrast Agents in Patients With CKD: A Review Am J Kidney Dis 77 : 517-528,2021.

Shaefi S, Brenner SK, Gupta S, O'Gara BP, Krajewski ML, Charytan DM, Chaudhry S, Mirza SH, Peev V, Anderson M, Bansal A, Hayek SS, Srivastava A, Mathews KS, Johns TS, Leonberg-Yoo A, Green A, Arunthamakun J, Wille KM, Shaukat T, Singh H, Admon AJ, Semler MW, Hernán MA, Mueller AL, Wang W, Leaf DE; STOP-COVID Investigators.: Extracorporeal membrane oxygenation in patients with severe respiratory failure from COVID-19 Intensive Care Med 47 : 208-221,2021.

Gupta S, Wang W, Hayek SS, Chan L, Mathews KS, Melamed ML, Brenner SK, Leonberg-Yoo A, Schenck EJ, Radbel J, Reiser J, Bansal A, Srivastava A, Zhou Y, Finkel D, Green A, Mallappallil M, Faugno AJ, Zhang J, Velez JCQ, Shaefi S, Parikh CR, Charytan DM, Athavale AM, Friedman AN, Redfern RE, Short SAP, Correa S, Pokharel KK, Admon AJ, Donnelly JP, Gershengorn HB, Douin DJ, Semler MW, Hernán MA, Leaf DE; STOP-COVID Investigators.: Association Between Early Treatment With Tocilizumab and Mortality Among Critically Ill Patients With COVID-19 JAMA Intern Med 181 : 41-51,2021.

Gupta S, Coca SG, Chan L, Melamed ML, Brenner SK, Hayek SS, Sutherland A, Puri S, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Schenck EJ, Goyal N, Hedayati SS, Dy R, Bansal A, Athavale A, Nguyen HB, Vijayan A, Charytan DM, Schulze CE, Joo MJ, Friedman AN, Zhang J, Sosa MA, Judd E, Velez JCQ, Mallappallil M, Redfern RE, Bansal AD, Neyra JA, Liu KD, Renaghan AD, Christov M, Molnar MZ, Sharma S, Kamal O, Boateng JO, Short SAP, Admon AJ, Sise ME, Wang W, Parikh CR, Leaf DE; and the STOP-COVID Investigators.: AKI Treated with Renal Replacement Therapy in Critically Ill Patients with COVID-19 J Am Soc Nephrol 32 : 161-176,2021.

Al-Samkari H, Gupta S, Leaf RK, Wang W, Rosovsky RP, Brenner SK, Hayek SS, Berlin H, Kapoor R, Shaefi S, Melamed ML, Sutherland A, Radbel J, Green A, Garibaldi BT, Srivastava A, Leonberg-Yoo A, Shehata AM, Flythe JE, Rashidi A, Goyal N, Chan L, Mathews KS, Hedayati SS, Dy R, Toth-Manikowski SM, Zhang J, Mallappallil M, Redfern RE, Bansal AD, Short SAP, Vangel MG, Admon AJ, Semler MW, Bauer KA, Hernán MA, Leaf DE; STOP-COVID-19 Investigators.: Thrombosis, Bleeding, and the Observational Effect of Early Therapeutic Anticoagulation on Survival in Critically Ill Patients With COVID-19 Ann Intern Med : 2021.

Academic Contact Information

Penn Presbyterian Medical Center
51 N. 39th Street
Medical Office Building, Suite 240

Philadelphia, PA 19104
Patient appointments: 800-789-7366