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Medical School: Harvard University
Residency: Brigham and Women's Hospital
Residency: Massachusetts General Hospital
Fellowship: Pennsylvania Hospital

American Academy of Neurology Science Committee (Clinical Research Subcommitee), National American Academy of Neurology, National Burroughs Wellcome Fund, National Interurban Clinical Club, National Israel Science Foundation, International Michael J. Fox Foundation, International National Institutes of Neurological Disorders and Stroke Parkinson's Disease Biomarker Program, National National Institutes of Neurological Disorders and Stroke, National National Institutes of Neurological Disorders and Stroke, National NIH National Institutes of Neurological Disorders and Stroke Parkinson's Disease Biomarker Program, Michael J. Fox Foundation joint Biospecimen Request Access Committee, International NIH, National NIH, National NIH, National Paul and Daisy Soros Fellowship for New Americans, National Rhodes Scholarship, International Society for Neuroscience, International

Hospital Privileges:

• Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
• Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
• Pennsylvania Hospital: Has privileges to treat patients in the hospital.

Description of Research Expertise:

The over-arching goal of our research is to better understand the mechanisms of neurodegenerative disease in order to intervene in these disease processes. Our general approach is to use unbiased genomic- or proteomic-scale screens to generate leads, which are then followed mechanistically in relevant systems. The rationale behind using genomic/proteomic-scale screens of genetic variation, mRNA expression, microRNA expression, or protein expression is that (1) they avoid bias generated by one’s preconceptions of what may be key disease genes or proteins and (2) they can give one a more global picture of pathophysiology, a picture that encompasses what is happening to an organism as a whole, or at least an organism’s genome/proteome as a whole, as these diseases progress. To conduct the type of research outlined here, we employ a combination of bench and computational methods.