Description of Research Expertise:
Alexander Lin, M.D., is Associate Professor in the Department of Radiation Oncology at the Perelman School of Medicine, and the Medical Director of the Roberts Proton Therapy Center at the University of Pennsylvania. Dr. Lin leads research programs in personalized approaches in the multidisciplinary treatment of head and neck cancer. Dr. Lin leads studies in novel methods of toxicity mitigation in patients with Human Papillomavirus (HPV)-associated cancers of the oropharynx. He also specializes in clinical trials investigating new radiosensitizing agents targeting the tumor microenvironment to improve disease outcomes, for which he receives funding from the National Cancer Institute (NCI) and National Institutes of Health (NIH).
Dr. Lin completed his undergraduate studies at Yale University and his medical training at the University of Michigan. He is a board-certified radiation oncologist and practicing physician at the University of Pennsylvania, Perelman School of Medicine.
Gershowitz J, Chao HH, Doucette A, Lukens JN, Swisher-McClure S, Weinstein GS, O’Malley Jr BW, Chalian AA, Rassekh CH, Newman JG, Cohen RB, Bauml JM, Aggarwal C, Lin A: Risk of Post-Operative, Pre-Radiotherapy Contralateral Neck Recurrence in Patients Treated with Surgery Followed by Adjuvant Radiotherapy for Human Papilloma Virus-Associated Tonsil Cancer British Journal of Radiology 92 : 20190466,2019.
Men K, Geng H, Zhong H, Fan Y, Lin A, Xiao Y: A deep learning model for predicting xerostomia due to radiotherapy
for head-and-neck squamous cell carcinoma in the RTOG 0522
clinical trial International Journal of Radiation Oncology, Biology, Physics 105 (2): 440-447,2019.
Grewal A, Jones J, Lin A: Palliative radiation therapy for head and neck cancers International Journal of Radiation Oncology, Biology, Physics 105 (2): 254-266,2019.
Baumann B, Lustig R, Mazzoni S, Grady MS, O'Malley Jr. B, Lee J, Newman J, Schuster J, Both S, Lin A, Dorsey J, Alonso-Basanta M: A Prospective Clinical Trial of Proton Therapy for Chordoma and Chondrosarcoma: Feasibility Assessment Journal of Surgical Oncology 120 (2): 200-205,2019.
Rwigema JM, Langendijk JA, van der Laan HP, Lukens JN, Swisher-McClure SD, Lin A: A model-based approach to predict short-term toxicity benefits with proton therapy for oropharyngeal cancer International Journal of Radiation Oncology, Biology, Physics 104 (3): 553-562,2019.
Anderson CM, Kimple RJ, Lin A, Karam SD, Margalit DN, Chua MLK: Oncology Scan: De-Escalation strategies in HPV-associated oropharynx cancer - Are we putting the Cart before the Horse?
International Journal of Radiation Oncology, Biology, Physics 104 (4): 705-709,2019.
Men K, Geng H, Cheng C, Zhong H, Huang M, Fan Y, Plastaras JP, Lin A, Xiao Y: More accurate and efficient segmentation of organs-at-risk in radiotherapy with Convolutional Neural Networks Cascades
Medical Physics 46 (1): 286-292,2019.
Aggarwal C, Cohen RB, Morrow MP, Kraynak KA, Sylvester AJ, Knoblock DM, Bauml J, Weinstein GS, Lin A, Boyer J, Sakata L, Tan S, Anton A, Dickerson K, Mangrolia D, Vang R, Dallas M, Oyola S, Duff S, Esser MT, Kumar R, Weiner DB, Csiki I, and Bagarazzi M: Immunotherapy targeting HPV 16/18 generates potent immune responses in HPV-Associated Head and Neck Cancer Clinical Cancer Research 25 (1): 110-124,2019.
Huang S, Souris K, Li S, Kang M, Montero AMB, Janssens G, Lin A, Garver E, Ainsley C, Taylor P, Xiao Y, Lin L: Validation and application of a fast Monte Carlo algorithm for assessing the clinical impact of approximations in analytical dose calculations for pencil beam scanning proton therapy Medical Physics 45 (12): 5631-5642,2018 .
Li T, Scheuermann R, Lin A, Teo BK, Zou W, Swisher-McClure S, Alonso-Basanta M, Lukens JN, Ghiam AF, Kennedy C, Kim MM, Mihailidis D, Metz JM, Dong L: Impact of Multi-leaf Collimator Parameters on Head and Neck Plan Quality and Delivery: A Comparison between Halcyon and Truebeam Treatment Delivery Systems Cureus : e3648,2018.