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Perelman Center for Advanced Medicine
West Pavilion, 3rd Floor
3400 Civic Center Boulevard
Philadelphia, PA 19104
A facility of the Hospital of the University of Pennsylvania
Penn Medicine Radnor
Floor 2, Suite 204 South
145 King of Prussia Road
Radnor, PA 19087
Penn Presbyterian Medical Center
51 N. 39th Street
Philadelphia, PA 19104
A facility of Penn Presbyterian Medical Center
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Gene therapy for retinal degeneration, gene therapy for ocular neovascularization, Subretinal surgery
Mowad TG, Willett AE, Mahmoudian M, Lipin M, Heinecke A, Maguire AM, Bennett J, Ashtari M: Compensatory Cross-Modal Plasticity Persists After Sight Restoration.
Front Neurosci 12 (14): 291,2020.
Maguire, Albert M; Russell, Stephen; Wellman, Jennifer A; Chung, Daniel C; Yu, Zi-Fan; Tillman, Amy; Wittes, Janet; Pappas, Julie; Elci, Okan; Marshall, Kathleen A; McCague, Sarah; Reichert, Hannah; Davis, Maria; Simonelli, Francesca; Leroy, Bart P; Wright, J Fraser; High, Katherine A; Bennett, Jean.: Efficacy, Safety, and Durability of Voretigene Neparvovec-rzyl in RPE65 Mutation-Associated Inherited Retinal Dystrophy: Results of Phase 1 and 3 Trials. Ophthalmology 126 (9): 1273-1285,2019.
Aleman, Tomas S; Uyhazi, Katherine E; Serrano, Leona W; Vasireddy, Vidyullatha; Bowman, Scott J; Ammar, Michael J; Pearson, Denise J; Maguire, Albert M; Bennett, Jean.: RDH12 Mutations Cause a Severe Retinal Degeneration With Relatively Spared Rod Function. Investigative Ophthalmology & Visual Science 59 (12): 5225-5236,2018.
Silson, Edward H; Aleman, Tomas S; Willett, Aimee; Serrano, Leona W; Pearson, Denise J; Rauschecker, Andreas M; Maguire, Albert M; Baker, Chris I; Bennett, Jean; Ashtari, Manzar.: Comparing Clinical Perimetry and Population Receptive Field Measures in Patients with Choroideremia. Investigative Ophthalmology & Visual Science 59 (8): 3249-3258,2018.
Song, Ji Yun; Aravand, Puya; Nikonov, Sergei; Leo, Lanfranco; Lyubarsky, Arkady; Bennicelli, Jeannette L; Pan, Jieyan; Wei, Zhangyong; Shpylchak, Ivan; Herrera, Pamela; Bennett, Daniel J; Commins, Nicoletta; Maguire, Albert M; Pham, Jennifer; den Hollander, Anneke I; Cremers, Frans P M; Koenekoop, Robert K; Roepman, Ronald; Nishina, Patsy; Zhou, Shangzhen; Pan, Wei; Ying, Gui-Shuang; Aleman, Tomas S; de Melo, Jimmy; McNamara, Ilan; Sun, Junwei; Mills, Jason; Bennett, Jean.: Amelioration of Neurosensory Structure and Function in Animal and Cellular Models of a Congenital Blindness. Molecular Therapy 26 (6): 1581-1593,2018.
Russell, Stephen; Bennett, Jean; Wellman, Jennifer A; Chung, Daniel C; Yu, Zi-Fan; Tillman, Amy; Wittes, Janet; Pappas, Julie; Elci, Okan; McCague, Sarah; Cross, Dominique; Marshall, Kathleen A; Walshire, Jean; Kehoe, Taylor L; Reichert, Hannah; Davis, Maria; Raffini, Leslie; George, Lindsey A; Hudson, F Parker; Dingfield, Laura; Zhu, Xiaosong; Haller, Julia A; Sohn, Elliott H; Mahajan, Vinit B; Pfeifer, Wanda; Weckmann, Michelle; Johnson, Chris; Gewaily, Dina; Drack, Arlene; Stone, Edwin; Wachtel, Katie; Simonelli, Francesca; Leroy, Bart P; Wright, J Fraser; High, Katherine A; Maguire, Albert M.: Efficacy and safety of voretigene neparvovec (AAV2-hRPE65v2) in patients with RPE65-mediated inherited retinal dystrophy: a randomised, controlled, open-label, phase 3 trial. Lancet 390 : 849-860,2017.
Ashtari, Manzar; Nikonova, Elena S; Marshall, Kathleen A; Young, Gloria J; Aravand, Puya; Pan, Wei; Ying, Gui-Shuang; Willett, Aimee E; Mahmoudian, Mani; Maguire, Albert M; Bennett, Jean.: The Role of the Human Visual Cortex in Assessment of the Long-Term Durability of Retinal Gene Therapy in Follow-on RPE65 Clinical Trial Patients. Ophthalmology 124 (6): 873-883,2017.
Parikh, Rupin N; Traband, Anastasia; Kolomeyer, Anton M; VanderBeek, Brian L; Kim, Benjamin J; Maguire, Albert M; Brucker, Alexander J.: Intravitreal Bevacizumab for the Treatment of Vitreous Hemorrhage Due to Proliferative Diabetic Retinopathy. American Journal of Ophthalmology 176 : 194-202,2017.
Aleman, Tomas S; Han, Grace; Serrano, Leona W; Fuerst, Nicole M; Charlson, Emily S; Pearson, Denise J; Chung, Daniel C; Traband, Anastasia; Pan, Wei; Ying, Gui-Shuang; Bennett, Jean; Maguire, Albert M; Morgan, Jessica I W.: Natural History of the Central Structural Abnormalities in Choroideremia: A Prospective Cross-Sectional Study. Ophthalmology 124 (3): 359-373,2017.
Ramachandran Pavitra, Lee Vivian, Wei Zhangyong, Song Ji Yun, Casal Giulia, Cronin Therese, Willett Keirnan, Huckfeldt Rachel, Morgan Jessica I W, Aleman Tomas S, Maguire Albert M, Bennett Jean: Evaluation of dose and safety of AAV7m8 and AAV8BP2 in the non-human primate retina. Human gene therapy : 2016.
Scheie Eye InstituteDepartment of OphthalmologyUniversity of Pennsylvania51 North 39th Street
Patient appointments: 800-789-7366