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Albert M. Maguire, MD

Albert M. Maguire, MD Physician

Professor of Ophthalmology at the Hospital of the University of Pennsylvania and the Presbyterian Medical Center of Philadelphia

Dr. Maguire is a Penn Medicine employed physician.

About Dr. Albert M. Maguire

Recognized by Best Doctors in America 2003-2004, 2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014

Recognized by Suburban Life magazine's "Top Physicians 2010" issue

Recognized in Philadelphia Magazine's May 2002 Top Docs issue

Clinical Specialties


  • Ophthalmology

Programs & Centers:

Board Certification:

  • Ophthalmology, 1991

Clinical Expertise:

  • Age-related Macular Degeneration (AMG)
  • AIDS-related Eye Disorders
  • Choroidal Tumor
  • Cryosurgery
  • Diabetic Retinopathy
  • Diabetic Retinopathy - Laser
  • Eye Emergencies
  • Eye Floaters
  • Eye Inflammation
  • Eye Orbital Tumor
  • Gene Therapy
  • Genetic Eye Diseases (GED)
  • Laser Therapy for Vitreoretinal Disease
  • Macular Degeneration - Laser Treatment
  • Macular Degneration
  • Macular Disorders
  • Macular Hole
  • Melanoma
  • Pediatric Ophthalmology
  • Retina Surgery
  • Retinal Degeneration
  • Retinal Detachment
  • Retinal Disorders
  • Retinal Edema
  • Retinal Hole
  • Retinal Infection (Retinitis)
  • Retinal Laser Therapy
  • Retinal Tears
  • Retinal Tumors
  • Retinal Vascular Disease
  • Sickle Cell Retinopathy
  • Uveitis
  • Vision Loss
  • Vitreous Surgery (Vitrectomy)

Description of Clinical Expertise

diabetic retinopathy, retinopathy of prematurity, macular degeneration, sickle cell disease, gene therapy, retinal degeneration

Practice Locations and Appointments

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Superior Vision Benefit Mgmt, Inc (Block Vision)
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: Harvard Medical School
Residency: Yale-New Haven Hospital
Residency: Johns Hopkins Hospital
Fellowship: Beaumont Hospital, Royal Oak


American Academy of Ophthalmology, National American Society for Cell and Gene Therapy, National Association for Research in Vision and Ophthalmology, National National Academy of Sciences, National NIH Study Section (National Eye Institute), National Ophthalmic Technology Assessment Committee, American Academy of Ophthalmology, National Ophthalmological Associate, Research to Prevent Blindness, National Phi Beta Kappa Society, National The Macula Society, National The Vitreous Society, National The Wellcome Trust, International

Hospital Affiliation

Dr. Maguire is a Penn Medicine employed physician.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Description of Research Expertise:

Gene therapy for retinal degeneration, gene therapy for ocular neovascularization, Subretinal surgery

Selected Publications:

Ashtari Manzar, Zhang Hui, Cook Philip A, Cyckowski Laura L, Shindler Kenneth S, Marshall Kathleen A, Aravand Puya, Vossough Arastoo, Gee James C, Maguire Albert M, Baker Chris I, Bennett Jean: Plasticity of the human visual system after retinal gene therapy in patients with Leber's congenital amaurosis. Science translational medicine 7 (296): 296ra110,2015.

Morgan Jessica I W, Han Grace, Klinman Eva, Maguire William M, Chung Daniel C, Maguire Albert M, Bennett Jean: High-resolution adaptive optics retinal imaging of cellular structure in choroideremia. Investigative ophthalmology & visual science 55 (10): 6381-97,2014.

Black Aaron, Vasireddy Vidyullatha, Chung Daniel C, Maguire Albert M, Gaddameedi Rajashekhar, Tolmachova Tania, Seabra Miguel, Bennett Jean: Adeno-associated virus 8-mediated gene therapy for choroideremia: preclinical studies in in vitro and in vivo models. The journal of gene medicine 16 (5-6): 122-30,2014.

Vasireddy Vidyullatha, Mills Jason A, Gaddameedi Rajashekhar, Basner-Tschakarjan Etiena, Kohnke Monika, Black Aaron D, Alexandrov Krill, Zhou Shangzhen, Maguire Albert M, Chung Daniel C, Mac Helen, Sullivan Lisa, Gadue Paul, Bennicelli Jeannette L, French Deborah L, Bennett Jean: AAV-mediated gene therapy for choroideremia: preclinical studies in personalized models. PloS one 8 (5): e61396,2013.

Vandenberghe Luk H, Bell Peter, Maguire Albert M, Xiao Ru, Hopkins Tim B, Grant Rebecca, Bennett Jean, Wilson James M: AAV9 targets cone photoreceptors in the nonhuman primate retina. PloS one 8 (1): e53463,2013.

Bennett J, Ashtari M, Wellman J, Marshall KA, Cyckowski LL, Chung DC, McCague S, Pierce EA, Chen Y, Bennicelli JL, Zhu X, Ying GS, Sun J, Wright JF, Auricchio A, Simonelli F, Shindler KS, Mingozzi F, High KA, Maguire AM.: AAV2 Gene Therapy Readministration in Three Adults with Congenital Blindness. Sci Transl Med. 4 (120): 120ra15,2012.

Ashtari M, Cyckowski LL, Monroe JF, Marshall KA, Chung DC, Auricchio A, Simonelli F, Leroy BP, Maguire AM, Shindler K, Bennett J.: The human visual cortex responds to gene therapy–mediated recovery of retinal function J Clin Invest. 121 (6): 2160-8,2011.

Vandenberghe LH, Bell P, Maguire AM, Cearley CN, Xiao R, Calcedo R, Wang L, Castle MJ, Maguire AC, Grant R, Wolfe JH, Wilson JM, Bennett J.: Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med. 3 (88): 88ra54,2011.

Simonelli F, Maguire AM, Testa F, Pierce EA, Mingozzi F, Bennicelli JL, Rossi S, Marshall K, Banfi S, Surace EM, Sun J, Redmond TM, Zhu X, Shindler KS, Ying GS, Ziviello C, Acerra C, Wright JF, McDonnell JW, High KA, Bennett J, Auricchio A.: Gene therapy for Leber's congenital amaurosis is safe and effective through 1.5 years after vector administration. Mol Ther. 18 (3): 643-50,2010.

Amado D, Mingozzi F, Hui D, Bennicelli JL, Wei Z, Chen Y, Bote E, Grant RL, Golden JA, Narfstrom K, Syed NA, Orlin SE, High KA, Maguire AM, Bennett J.: Safety and efficacy of subretinal readministration of a viral vector in large animals to treat congenital blindness. Sci Transl Med. 2 (21): 21ra16,2010.

Academic Contact Info

Scheie Eye Institute
Department of Ophthalmology
University of Pennsylvania
51 North 39th Street

Philadelphia, PA 19104
Patient appointments: 800-789-PENN (7366)

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