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Alain H. Rook, MD

Alain H. Rook, MD Physician

Director, Photopheresis Program Professor of Dermatology

Languages spoken:

  • French

Dr. Rook is employed by Penn Medicine.

About Dr. Alain H. Rook

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012 - 2018

Recognized by Best Doctors in America 2005 - 2018

Recognized annually in Philadelphia magazine's Top Docs issue from 2004 to 2019

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Clinical Specialties


  • Dermatology

Programs & Centers:

Board Certification:

  • Dermatology, 1991
  • Internal Medicine, 1979
  • Nephrology, 1980

Clinical Expertise:

  • Acne
  • Allergic Vasculitis
  • Anal Warts (Condyloma Acuminata)
  • Athlete's Foot
  • Autoimmune Blistering Disorders
  • Basal Cell Carcinoma
  • Benign Neoplasm of Skin
  • Birthmarks
  • Bullous Pemphigoid
  • Cellulitis
  • Chemical Peel
  • Chronic Wounds
  • Cracked and Dry Skin
  • Cutaneous T-Cell Lymphoma
  • Dermal Fillers
  • Dermatitis
  • Dermatomyositis
  • Epidermolysis Bullosa
  • Erythema
  • Female Pattern Baldness
  • Folliculitis
  • Fungal Skin Infections (Dermatomycosis)
  • Genital Warts (Condyloma Acuminatum)
  • Glomangioma
  • Glomus Tumor
  • Hair Diseases
  • Hair Lice
  • Hair Loss (Alopecia Areata)
  • Hemangiomas
  • Herpes Simplex Virus (HSV)
  • Hirsutism
  • Hives (Urticaria)
  • Hypertrichosis
  • Keloid Scar
  • Laser Skin Rejuvenation
  • Lipoma
  • Liposuction (Lipoplasty)
  • Male Pattern Baldness
  • Melanoma
  • Merkel Cell Carcinoma
  • Nail Disorders
  • Nail Fungus
  • Non-Melanoma Skin Cancer
  • Photosensitivity Reactions
  • Pigmented Lesions
  • Pressure Ulcers
  • Psoriasis
  • Rash
  • Rosacea
  • Scabies
  • Scalp Disorders
  • Shingles
  • Skin Aging
  • Skin Cancer
  • Skin Cancer Surgery
  • Skin Disorders
  • Skin Patch Tests
  • Skin Pigmentation Disorders
  • Skin Ulcer
  • Staph Infection
  • Sun Damaged Skin
  • Vitiligo
  • Warts
View More

Practice Locations and Appointments

  • Penn Dermatology Perelman

    Perelman Center for Advanced Medicine South Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Amerihealth Caritas
  • Amerihealth Caritas Medicare
  • Cigna
  • Cigna HealthSpring
  • Clover Health Plan
  • CVS Health
  • Devon Health Services (Americare)
  • eLAP Services
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Homestead Smart Health Plans
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Health and Wellness (Centene) Medicare
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Provider Partners Health Plan
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan
  • Veterans Choice Program

Education and Training

Medical School: University of Michigan
Residency: McGill University Hospitals
Fellowship: McGill University Hospitals
Fellowship: National Institutes of Health
Residency: Hospital of the University of Pennsylvania


American Academy of Dermatology, National American Dermatological Association, National American Federation for Medical Research, National Canadian Dermatological Association (Honorary), International International Cutaneous Lymphoma Society, International Pennsylvania Academy of Dermatology, Local Society for Investigative Dermatology, National Society for Investigative Dermatology, National United States Cutaneous Lymphoma Consortium, National

Hospital Affiliation

Dr. Rook is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: On the medical staff, but does not have privileges to treat patients in the hospital.


Selected Publications:

Cedeno-Laurent F, Singer Em, Wysocka M, Benoit BM, Vittorio CC, Kim EJ, Yosipovitch G, Rook AH.: Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities. Clin Immunol 158 (1): 1-7,2015.

Kim EJ, Kim YH, Rook AH, Lerner A, Duvic M, Reddy S, Robak T, Becker JC: Clinically significant responses achieved with romidespsin across disease compartments in patients with cutaneous T-cell lymphoma Leuk Lymphoma (20): 1-22,2015.

Kim EJ, Kim YH, Rook AH, Lerner A, Duvic M, Reddy S, Robak T, Becker JC, Samtsov A, McCulloch W, Waksman J, Whittaker S.: Clinically significant responses achieved with romidepsin across disease compartments in patients with cutaneous T-cell lymphoma. Leuk Lymphoma 20 : 1-22,2015.

Spaccarelli N, Gharavi M, Saboury B, Cheng G, Rook AH, Alavi A.: Role of (18)F-fluorodeoxyglucose positron emission tomography imaging in the management of primary cutaneous lymphomas. Hell J Nucl Med 17 (2): 78-84,2014.

Wysocka M, Kossenkov AV, Benoit BM, Troxel AB, Singer E, Schaffer A, Kim B, Dentchev T, Nagata S, Ise T, Showe LC, Rook AH.: CD164 and FCRL3 are highly expressed on the CD4+CD26- T-cells in Sezary Syndrome patients. J Invest Dermatol 134 : 229-36,2014.

Samimi S, Chu E, Seykora J, Loren A, Vittorio C, Rook A, Rosenbach M, Kim EJ.: Dasatinib-induced leukotrichia in a patient with chronic myelogenous leukemia. JAMA Dermatol 149 (5): 2013.

Kim YH, Demierre MF, Kim EJ, Lerner A, Rook AH, Duvic M, Robak T, Samtsov A, McCulloch W, Chen SC, Waksman J, Nichols J, Whittaker S.: Clinically meaningful reduction in pruritus in patients with cutaneous T-cell lymphoma treated with romidepsin. Leuk Lymphoma 54 (2): 284-9,2013.

Lessin SR, Duvic M, Guitart J, Pandya AG, STrober BE, Olsen EA, Hull CM, Knobler EH, Rook AH, Kim EJ, Naylor MF, Adelson DM, Kimball AB, Wood GS, Sundram U, Wu H, Kim YH.: Topical chemotherapy in cutaneous T-cell lymphoma: Positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02% gel, in mycosis fungoides. JAMA Dermatol 149 (1): 25-32,2013.

Samimi S, Morrissey K, Anshelevich S, Evans K, Gardner J, Musiek A, Vittorio C, Rook A, Kim E.: Romidepsin and interferon gamma: A novel combination for refractory cutaneous T-cell lymphoma. J Am Acad Dermatol 68 (1): e5-6,2013.

Klein RS, Dunlop JD, Samimi SS, Morrissey KA, Evans KG, Gardner JM, Introcaso CE, Vittorio CC, Rook AH, Micaily B, Kim EJ.: Improvement in peripheral blood disease burden in patients with Sezary syndrome and leukemic mycosis fungoides after total skin electron beam therapy. J Am Acad Dermatol 68 : 972-7,2013.

Academic Contact Info

Department of Dermatology
3400 Civic Center Boulevard
Perelman Center for Advanced Medicine
Philadelphia, Pa. 19104

Philadelphia, PA 19104
Phone: (215) 662-7610
Patient appointments: 800-789-7366 (PENN)

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