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Alain H. Rook, MD

Alain H. Rook, MD Physician

Director, Photopheresis Program Professor of Dermatology

Languages spoken:

  • French

Dr. Rook is employed by Penn Medicine.

About Dr. Alain H. Rook

Recognized annually in Philadelphia magazine's Top Docs issue from 2004 through 2017

Recognized by America's Top Doctors, 2007, 2008, 2010, 2012-14

Recognized by Best Doctors in America 2005-2006, 2007-2008, 2009-2010, 2011-2012, 2013-2014

Patient Satisfaction Ratings

Patient Rating Breakdown

The Patient Satisfaction Rating is an average of all responses to the care provider related questions shown below from our nationally-recognized Press Ganey Patient Satisfaction Survey. Patients that are treated in outpatient or hospital environments may receive different surveys, and the volume of responses will vary by question.

Responses are measured on a scale of 1 to 5 with 5 being the best score.

The comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Overall Ratings

Patient Comments

Clinical Specialties


  • Dermatology

Programs & Centers:

Board Certification:

  • Dermatology, 1991
  • Internal Medicine, 1979
  • Nephrology, 1980

Clinical Expertise:

  • Autoimmune Skin Disorders
  • Cutaneous T-Cell Lymphoma
  • Mycosis Fungoide
  • Skin Lesion Biopsy

Practice Locations and Appointments

  • Penn Dermatology

    Perelman Center for Advanced Medicine South Pavilion, 1st Floor 3400 Civic Center Boulevard Philadelphia, PA 19104 800-789-7366 (PENN)

    A facility of the Hospital of the University of Pennsylvania

Insurance Accepted

  • Aetna US Healthcare
  • Cigna
  • Cigna HealthSpring
  • CVS Health
  • Devon Health Services (Americare)
  • Gateway Health Plan
  • Geisinger Health Plan
  • HealthAmerica / HealthAssurance, a Coventry Plan
  • HealthPartners
  • HealthPartners Medicare
  • HealthSmart
  • Highmark Blue Shield
  • Horizon Blue Cross Blue Shield of New Jersey
  • Humana / Choicecare
  • Independence Blue Cross (Keystone East)
  • Intergroup
  • Keystone First
  • Keystone First Medicare
  • Multiplan
  • NJ Medicaid
  • NJ Qualcare
  • Oxford Health Plan
  • PA Medicaid
  • PA Medicare
  • Preferred Health Care/LGH
  • Rail Road Medicare / Palmetto GBA
  • Remedy Partners at Penn Medicine
  • Tricare
  • United Healthcare
  • UnitedHealthcare Community Plan
  • US Family Health Plan

Education and Training

Medical School: University of Michigan
Residency: McGill University Hospitals
Fellowship: McGill University Hospitals
Fellowship: National Institutes of Health
Residency: Hospital of the University of Pennsylvania


American Academy of Dermatology, National American Dermatological Association, National American Federation for Medical Research, National Canadian Dermatological Association (Honorary), International International Cutaneous Lymphoma Society, International Pennsylvania Academy of Dermatology, Local Society for Investigative Dermatology , National Society for Investigative Dermatology, National United States Cutaneous Lymphoma Consortium, National

Hospital Affiliation

Dr. Rook is employed by Penn Medicine.

Hospital Privileges:

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.


Selected Publications:

Kim EJ, Kim YH, Rook AH, Lerner A, Duvic M, Reddy S, Robak T: Clinically significant responses achieved with romidespsin across disease compartments in patients with cutaneous T-cell lymphoma Leuk Lymphoma (20): 1-22,2015.

Kim EJ, Kim YH, Rook AH, Lerner A, Duvic M, Reddy S, Robak T, Becker JC, Samtsov A, McCulloch W, Waksman J: Clinically significant responses achieved with romidepsin across disease compartments in patients with cutaneous T-cell lymphoma. Leuk Lymphoma 20 : 1-22,2015.

Cedeno-Laurent F, Singer Em, Wysocka M, Benoit BM, Vittorio CC, Kim EJ, Yosipovitch G: Improved pruritus correlates with lower levels of IL-31 in CTCL patients under different therapeutic modalities. Clin Immunol 158 (1): 1-7,2015.

Spaccarelli N, Gharavi M, Saboury B, Cheng G, Rook AH: Role of (18)F-fluorodeoxyglucose positron emission tomography imaging in the management of primary cutaneous lymphomas. Hell J Nucl Med 17 (2): 78-84,2014.

Wysocka M, Kossenkov AV, Benoit BM, Troxel AB, Singer E, Schaffer A, Kim B, Dentchev T, Nagata S, Ise T, Showe LC: CD164 and FCRL3 are highly expressed on the CD4+CD26- T-cells in Sezary Syndrome patients. J Invest Dermatol 134 : 229-36,2014.

Samimi S, Chu E, Seykora J, Loren A, Vittorio C, Rook A, Rosenbach M: Dasatinib-induced leukotrichia in a patient with chronic myelogenous leukemia. JAMA Dermatol 149 (5): 2013.

Kim YH, Demierre MF, Kim EJ, Lerner A, Rook AH, Duvic M, Robak T, Samtsov A, McCulloch W, Chen SC, Waksman J, Nichols J: Clinically meaningful reduction in pruritus in patients with cutaneous T-cell lymphoma treated with romidepsin. Leuk Lymphoma 54 (2): 284-9,2013.

Lessin SR, Duvic M, Guitart J, Pandya AG, STrober BE, Olsen EA, Hull CM, Knobler EH, Rook AH, Kim EJ, Naylor MF, Adelson DM, Kimball AB, Wood GS, Sundram U, Wu H: Topical chemotherapy in cutaneous T-cell lymphoma: Positive results of a randomized, controlled, multicenter trial testing the efficacy and safety of a novel mechlorethamine, 0.02% gel, in mycosis fungoides. JAMA Dermatol 149 (1): 25-32,2013.

Samimi S, Morrissey K, Anshelevich S, Evans K, Gardner J, Musiek A, Vittorio C, Rook A: Romidepsin and interferon gamma: A novel combination for refractory cutaneous T-cell lymphoma. J Am Acad Dermatol 68 (1): e5-6,2013.

Guenova E, Watanabe R, Teague JE, Desimone JA, Jiang Y, Dowlatshahi M, Schlapbach C, Schaekel K, Rook AH, Tawa M, Fisher DC, Kupper TS: TH2 cytokines from malignant cells suppress TH1 responses and enforce a global TH2 bias in leukemic cutaneous T-cell lymphoma. Clin Cancer Res 19 : 3755-63,2013.

Academic Contact Info

Department of Dermatology
3400 Civic Center Boulevard
Perelman Center for Advanced Medicine
Philadelphia, Pa. 19104

Philadelphia, PA 19104
Phone: (215) 662-7610
Patient appointments: 800-789-7366 (PENN)

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