Peter S. Klein, MD, PhD
Hematology
Penn Medicine Provider
About me
- Director, Physician-Scientist Program
- Professor of Medicine (Hematology-Oncology)
- Professor of Medicine in Cell and Developmental Biology
My education and training
- Medical School: Johns Hopkins University School of Medicine
- Residency: Massachusetts General Hospital
- Fellowship: Cambridge Health-Harvard Medical School
Spoken languages
English
English
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
- Aetna Advantra Cares D-SNP
- Aetna Advantra Credit Value
- Aetna Advantra Eagle HMO
- Aetna Advantra Eagle POS
- Aetna Advantra Premier Plus PPO
- Aetna Advantra Value
- Aetna Advantra Value Plus
- Aetna APCN Plus (Multi-Tier)
- Aetna Better Health Kids (CHIP) - DH Only
- Aetna Flexible Five
- Aetna Freedom Core
- Aetna Gold
- Aetna HMO
- Aetna Philly Prime
- Aetna POS
- Aetna PPO APCN
- Aetna Premier
- Aetna Premier Plus
- Aetna Savings Plus
- Aetna Signature Administrators
- Aetna Student Health Plan PPO
- Aetna Upfront Advantage
- First Health HMO
- First Health POS
- First Health PPO
- Meritain - Aramark (Other)
- Meritain - Aramark (Pennsylvania Premier Medical Plan)
- Americhealth Caritas of PA VIP - LGH Only
- Amerihealth Caritas (Transplant patients only)
- Amerihealth Caritas of PA - LGH Only
- Centivo EPO
- Cigna Healthcare EPO
- Cigna Healthcare HMO
- Cigna Healthcare POS
- Cigna Healthcare PPO
- Claim Watcher (Homestead/ INDECs) Open Access
- Clover Health Choice
- Clover Health Choice Value PPO
- Clover Health Classic HMO
- Clover Health Value
Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Qualifications and experience
- Hematology, 2008
- American Association for the Advancement of Science, National
- American Society for Clinical Investigation, National
- American Society for Microbiology, National
- American Society of Hematology, National
- Association of American Physicians, National
- National Institutes of Health, National
- NHLBI, NIH, R38 StARR study section, National
- NIH, National
- NIH, National
- NIH/NHLBI, National
- NIH2025, National
- Society for Developmental Biology, International
- Penn Hematological Malignancies (Blood Cancer) Program
- Penn Leukemia Program
Treatments and conditions
Research
Publications
Valvezan AJ, Huang J, Lengner CJ, Pack M, and PS Klein Oncogenic mutations in Adenomatous Polyposis Coli (Apc) activate mechanistic Target of Rapamycin Complex 1 (mTORC1) , Disease Models and Mechanisms, 7(1): 2014,63-71
Huang J, Nguyen-McCarty M, Hexner EO, Danet-Desnoyers G, and PS Klein Maintenance of Hematopoietic Stem Cells through regulation of Wnt and mTOR Pathways , Nature Medicine, 18: 2012,1778-1785
Valvezan AJ, Zhang FS, Diehl JA, and PS Klein Adenomatous Polyposis Coli (APC) regulates multiple signaling pathways by enhancing glycogen synthase kinase-3 (GSK-3) activity , Journal of Biological Chemistry, 287: 2012,3823-3832
Skirkanich J, Luxardi G, Yang J, Kodjabachian L, and PS Klein An essential role for transcription before the MBT in Xenopus laevis. , Developmental Biology, 357: 2011,478-491
O’Brien WT, Huang J, Buccafusca R, Garskof J, Valvezan AJ, Berry GT, and PS Klein Glycogen synthase kinase-3 is essential for β-arrestin-2 complex formation and lithium-sensitive behaviors in mice. , Journal of Clinical Investigation, 121: 2011,3756-3762
Blythe SA and Klein PS Prepatterning embryonic development: tabula scripta? , Developmental Cell, 21: 2011,977-978
Blythe SA, Cha SW, Tadjuidje E, Heasman J, Klein PS beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. , Developmental Cell, 19(2): 2010,220-231
Mazumdar J, O'Brien WT, Johnson RS, LaManna JC, Chavez JC, Klein PS, Simon MC O2 regulates stem cells through Wnt/β-catenin signalling. , Nature Cell Biology, 12(10): 2010,1007-13
Huang J, Zhang Y, Bersenev A, O'Brien WT, Tong W, Emerson SG, Klein PS Pivotal role for glycogen synthase kinase-3 in hematopoietic stem cell homeostasis in mice. , Journal of Clinical Investigation, 119(12): 2009,3519-29