Nithin Adappa, MD, is a Professor in the Department of Otorhinolaryngology at Penn Medicine. He is part of the Division of Rhinology and Skull Base Surgery, currently serving as the fellowship director. In addition, he is the surgical director of the AERD Center, treating Aspirin Exacerbated Respiratory Disease, also known as Samter’s triad. He has a particular interest in revision sinus surgery with special emphasis on challenging frontal and sphenoid sinus work. Dr. Adappa is also heavily involved in the surgical care of patients with sinonasal tumors, both benign and malignant, as well as cerebrospinal fluid leaks. He also works extensively with his neurosurgical colleagues to remove brain tumors that are accessible through the nose and sinuses.
Dr. Adappa has published over 250 peer-reviewed papers and is the editor of the “Atlas of Endoscopic Sinus and Skull Base Surgery.” His active research includes the development of topical therapeutics for chronic rhinosinusitis as well as outcomes and translational research in sinonasal and anterior skull base tumors. He is an active member of the American Rhinology Society and presents his research both nationally and internationally.
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Publications
Miller ZA, Mueller A, Thompson JC, Williams JS, Park A, Darwich NF, Kouakou YI, Sywanycz SM, Buchler BL, Adappa ND, Palmer JN, Cohen NA, Carey RM, Lee RJ. Pseudomonas aeruginosa 3-oxo-C12HSL-induced apoptosis involves bitter taste receptor T2R14 and the mitochondrial calcium uniporter , Cell Calcium, 136: 2026,103141
Halderman AA, Cheng MZ, Abiri A, Daniels KE, Pandrangi V, Workman AD, Chung S, Barnett SL, Adappa ND, Choby G, Gardner PA, Geltzeiler M, Palmer JN, Snyderman CH, Wang EW, Zenonos GA, Kuan EC. Factors influencing timing of cerebrospinal fluid leak after endoscopic skull base surgery: a multicenter study , Rhinology: 2026
Workman AD, Adappa ND, Batra PS, Chapurin N, Geltzeiler M, Gray ST, Palmer JN, Nyquist GG, Roxbury CR, Wang MB, Kuan EC. American Rhinologic Society Expert Practice Statement: Surveillance Strategies for Sinonasal Malignancy , Int Forum Allergy Rhinol: 2026
Maoz SL, Lee M, Fischer JL, Choby G, Hwang PH, Wang EW, Kuan EC, Adappa ND, Geltzeiler M, Getz AE, Humphreys IM, Le CH, Pinheiro-Neto CD, Chan EP, Roozdar P, Abuzeid WM, Chang EH, Jafari A, Kingdom TT, Kohanski MA, Lee JT, Lazor J, Nabavizadeh A, Nayak JV, Palmer JN, Patel ZM, Resnick AC, Smith TL, Snyderman CH, St John MA, Storm PB, Suh JD, Wang MB, Sim MS, Beswick DM. Minimal Clinically Important Difference of the Sinonasal Outcome Test in Sinonasal Malignancy , Ann Otol Rhinol Laryngol: 2026
Talati VM, Zhang K, Wei KX, Mitchell MB, Adappa ND, Kohanski MA, Douglas JE, Jackson C, Lee JYK, Storm PB, Lazor JW, Palmer JN. Fascia-Fat-Fascia "Sandwich Graft" Decreases Postoperative Cerebrospinal Fluid Leak Rate for High-Flow Skull Base Defects , Int Forum Allergy Rhinol: 2026
Herpin LP, Finuoli AM, Workman AD, Tang SH, Kuppusamy K, Kohanski MA, Palmer JN, Adappa ND, Douglas JE, Bosso JV. Factors influencing aspirin therapy after desensitization (ATAD) tolerance in aspirin-exacerbated respiratory disease (AERD) patients , Ann Allergy Asthma Immunol: 2026
Yu AJ, Venkatesh S, Wilensky J, Workman AD, Chang J, Espinosa M, Douglas JE, Palmer JN, Adappa ND, Kohanski MA. The Utility of Macrolide Therapy for Neutrophilic CRSsNP Based on Structured Histopathology , Laryngoscope: 2026
Panara K, Wilensky J, Workman AD, Lerner DK, Irace AL, Douglas JE, Palmer JN, Adappa ND, Jalaly J, Tong CCL, Cohen NA, Kohanski MA. MMP11 as a Prognostic Indicator for Inverted Papilloma Histologic Grade and Recurrence , Laryngoscope: 2026
Herpin LP, Bach R, Bruneto R, Faltas KA, Kohanski MA, Palmer JN, Adappa ND, Douglas JE, Bosso JV. Dupilumab-Related Adverse Events and Intolerance in Aspirin-Exacerbated Respiratory Disease Patients , Int Forum Allergy Rhinol: 2026
Yu AJ, Tapescu I, Venkatesh S, Montone K, Espinosa MC, Douglas JE, Palmer JN, Kohanski MA, Adappa ND. Diagnostic Accuracy of Office Biopsy for Inverted Papilloma , Am J Rhinol Allergy: 2026
