Nikhil Jiwrajka, MD
Rheumatology
Accepting new patients
Sees patients age 18 and up
Penn Rheumatology Perelman
Schedule onlineCall 215-662-2454
Penn Medicine Provider

About me

  • Instructor A of Medicine (Rheumatology)

Dr. Nikhil Jiwrajka, MD, is an Instructor of Medicine in the Division of Rheumatology at the University of Pennsylvania’s Perelman School of Medicine. He earned his MD from Johns Hopkins University School of Medicine and completed both his Internal Medicine residency and Rheumatology fellowship training at the Hospital of the University of Pennsylvania. Dr. Jiwrajka specializes in caring for individuals with scleroderma, autoimmune interstitial lung disease (“ILD”), myositis-associated lung disease, and related autoimmune diseases. His research, conducted in the lab of Dr. Montserrat Anguera, focuses on understanding why scleroderma and related autoimmune diseases preferentially afflict females, with the hope that this understanding can help inform the development of new diagnostics and treatments for patients with these diseases.

Education and training

  • Medical School: Johns Hopkins University School of Medicine
  • Residency: University of Pennsylvania Health System
  • Fellowship: University of Pennsylvania Health System

What my patients think about me

Average Rating

125 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

October 2025
good patient relations
October 2025
very comprehensive visits. he takes time to listen and evaluate all that we discussed
September 2025
dr. j. would do everything in his ability to help them live a healthier lifestyle.
August 2025
always professional, polite. kindness & respect to my concerns.

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Jiwrajka is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Forsyth KS, Toothacre NE, Jiwrajka N, Driscoll AM, Shallberg LA, Cunningham-Rundles C, Barmettler S, Farmer J, Verbsky J, Routes J, Beiting DP, Romberg N, May MJ, Anguera MC. Maintenance of X chromosome inactivation after T cell activation requires NF-κB signaling , Sci Immunol, 9: 2024,eado0398

Johnson SR, Bernstein EJ, Bolster MB, Chung JH, Danoff SK, George MD, Khanna D, Guyatt G, Mirza RD, Aggarwal R, Allen A Jr, Assassi S, Buckley L, Chami HA, Corwin DS, Dellaripa PF, Domsic RT, Doyle TJ, Falardeau CM, Frech TM, Gibbons FK, Hinchcliff M, Johnson C, Kanne JP, Kim JS, Lim SY, Matson S, McMahan ZH, Merck SJ, Nesbitt K, Scholand MB, Shapiro L, Sharkey CD, Summer R, Varga J, Warrier A, Agarwal SK, Antin-Ozerkis D, Bemiss B, Chowdhary V, Dematte D'Amico JE, Hallowell R, Hinze AM, Injean PA, Jiwrajka N, Joerns EK, Lee JS, Makol A, McDermott GC, Natalini JG, Oldham JM, Saygin D, Lakin KS, Singh N, Solomon JJ, Sparks JA, Turgunbaev M, Vaseer S, Turner A, Uhl S, Ivlev I. 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Treatment of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases , Arthritis Rheumatol: 2024

Johnson SR, Bernstein EJ, Bolster MB, Chung JH, Danoff SK, George MD, Khanna D, Guyatt G, Mirza RD, Aggarwal R, Allen A Jr, Assassi S, Buckley L, Chami HA, Corwin DS, Dellaripa PF, Domsic RT, Doyle TJ, Falardeau CM, Frech TM, Gibbons FK, Hinchcliff M, Johnson C, Kanne JP, Kim JS, Lim SY, Matson S, McMahan ZH, Merck SJ, Nesbitt K, Scholand MB, Shapiro L, Sharkey CD, Summer R, Varga J, Warrier A, Agarwal SK, Antin-Ozerkis D, Bemiss B, Chowdhary V, Dematte D'Amico JE, Hallowell R, Hinze AM, Injean PA, Jiwrajka N, Joerns EK, Lee JS, Makol A, McDermott GC, Natalini JG, Oldham JM, Saygin D, Lakin KS, Singh N, Solomon JJ, Sparks JA, Turgunbaev M, Vaseer S, Turner A, Uhl S, Ivlev I. 2023 American College of Rheumatology (ACR)/American College of Chest Physicians (CHEST) Guideline for the Screening and Monitoring of Interstitial Lung Disease in People with Systemic Autoimmune Rheumatic Diseases , Arthritis Rheumatol: 2024

Forsyth KS, Jiwrajka N, Lovell CD, Toothacre NE, Anguera MC. The conneXion between sex and immune responses , Nat Rev Immunol: 2024

Lovell CD, Jiwrajka N, Amerman HK, Cancro MP, Anguera MC. Xist Deletion in B Cells Results in Systemic Lupus Erythematosus Phenotypes , bioRxiv: 2024

Jiwrajka N, Toothacre NE, Beethem ZT, Sting S, Forsyth KS, Dubin AH, Driscoll A, Stohl W, Anguera MC. Impaired dynamic X-chromosome inactivation maintenance in T cells is a feature of spontaneous murine SLE that is exacerbated in female-biased models , J Autoimmun: 2023

Jiwrajka N, Loizidis G, Patterson KC, Kreider ME, Johnson CR, Miller WT Jr, Barbosa EJM Jr, Patel N, Beers MF, Litzky LA, George MD, Porteous MK. Identification and Prognosis of Patients With Interstitial Pneumonia With Autoimmune Features , J Clin Rheumatol, 28: 2022,257-264

Jiwrajka N, Anguera MC. The X in seX-biased immunity and autoimmune rheumatic disease , J Exp Med, 219: 2022,e20211487

Sciurba JC, Gieseck RL, Jiwrajka N, White SD, Karmele EP, Redes J, Vannella KM, Henderson NC, Wynn TA, Hart KM. Fibroblast-specific integrin-alpha V differentially regulates type 17 and type 2 driven inflammation and fibrosis , J Pathol: 2019