Nicole Belle, MD, PhD

Gastroenterology
Sees patients age 18 and up
Penn Gastroenterology Perelman
Call 215-349-8222
Headshot of Nicole Belle, MD, PhD
Penn Medicine Provider

About me

  • Assistant Professor of Medicine (Gastroenterology)

Dr. Belle performs procedures only.

My education and training

  • Medical School: Washington University School of Medicine
  • Residency: University of Pennsylvania Health System
  • Fellowship: University of Pennsylvania Health System

Spoken languages

English
English

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Belle is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

Research

Publications

Hairu Yang, Michaela Dungan, Bhoomi Madhu, Keely Beyries, Xin Wang, Robert Kilpatrick, Baron Chen, Sangmi Oh, Marissa Berkowitz, David Smith, Chaoting Zhou, Sergei B Koralov, Jordan Axelrad, Christopher J Lengner, Nicole Belle, Meenakshi Bewtra, Bryson W Katona, Ken Cadwell MAIT cell enrichment in Lynch syndrome is associated with immune surveillance and colorectal cancer risk , Gut: 2026

Belle NM M1 and M2 Macrophages Differentially Regulate Colonic Crypt Renewal , PracticeUpdate website: 2024

Lucas M Ethgen, Christopher Pastore, Cailu Lin, Danielle R Reed, Li-Yin Hung, Bonnie Douglas, Dominic Sinker, De'Broski R Herbert, Nicole M Belle A Trefoil factor 3- Lingo2 axis restrains proliferative expansion of type-1 T helper cells during GI nematode infection , Mucosal Immunology, 17(2): 2024,238-256

Nicole Belle, Christopher Pastore, Lucas Ethgen, De'Broski Herbert LINGO2 expression on T cells promote anti-helminth immunity , DDW 2022: 2022

Zullo, K.M, Douglas, B., Maloney N., Yingbiao J, Yun W, Herbine K, Cohen R, Pastore C, Cramer Z, Wang X, Wenjie W, Somsouk M, Hung L.Y., Lengner C, Kohanksi M.H., Cohen N.A and D. R. Herbert LINGO3 regulates mucosal tissue regeneration and promotes TFF2 dependent recovery from colitis , Scand J. Gastroenterology, 56(7): 2021,791-805

Nicole M Belle, Christopher Pastore, Erin Jean and De'Broski R Herbert LINGO2 expression on T cells selectively promotes anti-helminth immunity , Virtual Immunology: 2021

Nicole Belle Model System Has Answered Critical Questions , GI & Hepatology News: 2020

Nicole M Belle, Erin Jean, Joon Park and De’broski Herbert T cell expression of the transmembrane receptor, LINGO2 controls helminth induced colitis , Mucosal Immunology Course & Symposium : 2020

Belle NM, Ji Y, Wei Y, Park J, Srivatsa S, Hung LY, Young T, Herbine K, Oniskey T, Pastore C, Nieves W, Somsouk M, Herbert DR TFF3 interacts with LINGO2 to regulate EGFR activation for protection against colitis and gastrointestinal helminths , Nature Communications, 10(1): 2019,4408

Maloney NS, Thackray LB, Goel G, Hwang S, Duan E, Vachharajani P, Xavier R, Virgin HW Essential cell autonomous role for interferon regulatory factor 1 in interferon-γ-mediated inhibition of norovirus replication in macrophages , J. Virol, 86(23): 2012,12655-64