Monica A. Mainigi, MD
she/her/hers
Reproductive Endocrinology and Infertility
LGBTQ+ affirming provider
Accepting new patients
Sees patients age 4 to 65
Penn Fertility Care
Make an appointmentCall 800-789-7366
Penn Medicine Provider

About me

  • Program Director, Fellowship in Reproductive Endocrinology and Infertility
  • Associate Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania

Education and training

  • Medical School: New York University School of Medicine
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

What my patients think about me

Average Rating

101 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

October 2025
she is flexible with appointments with my special needs daughter and really has gone above and beyond to help her
September 2025
so professional
September 2025
good provider
August 2025
very nice and understanding

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Lancaster General Hospital: Has privileges to treat patients in the hospital.
  • Princeton Medical Center: Has privileges to treat patients in the hospital.
Dr. Mainigi is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Merlino MS, Barksdale B, Negatu SG, Clements RL, Miller-Ensminger T, Lopez AH, Mani S, Mainigi M, Hunter CA, Jurado KA. Interleukin-27 is antiviral at the maternal-fetal interface. , Nature Communication, Accepted for Publication: 2025

Sneha Mani, Se-Jeong Kim, Rosemary Flock, Dongeun Huh, Monica Mainigi Microfluidic organ-on-chip device: a unique platform for investigating implantation and placentation , Fertil Steril , S0015-0282: 2025

Thea N Golden, Sneha Mani, Rebecca L Linn, Rita Leite, Natalie A Trigg, Annette Wilson, Lauren Anton, Monica Mainigi, Colin C Conine, Brett A Kaufman, Jerome F Strauss, Samuel Parry, Rebecca A Simmons Extracellular vesicles alter trophoblast function in pregnancies complicated by COVID-19 , J Extracell Vesicles 2025: 2025

Simoni MK, Negatu SG, Park JY, Mani S, Arreguin MC, Amses KR, Huh DD, Mainigi M*, Jurado KA* Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function. , Cell Rep Med. , 6(3):101991: 2025

Pollie MP, Peipert B, Kim S, Mainigi MA. Isolated Inhibin-Producing Granulosa Cell Tumor Causing Primary Amenorrhea: A Case Report. , J Pediatr Adolesc Gynecol, ePUB ahead of print: 2025

Chen X, Tober J, Dominguez M, Tang AT, Bockman J, Yang J, Mani S, Lee CN, Chen M, Thillaikumaran T, Mericko-Ishizuka P, Mainigi M, Speck NA, Kahn ML. Lineage tracing studies suggest that the placenta is not a de novo source of hematopoietic stem cells. , PLoS Biol. , 23(1):e3003003: 2025

Leigh A Humphries, Jeremy Applebaum, Monica A Mainigi, Caitlin Martin, Divya K Shah Predicting a successful match among applicants to reproductive endocrinology and infertility fellowship , Fertil Steril , Epub: 2024

Sneha Mani, James Garifallou, Se-jeong Kim, Michael K. Simoni, Dan Dongeun Huh, Scott M. Gordon and Monica Mainigi Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties , Frontiers in Immunology, 15:1364036: 2024

Hunter D. Reavis*, Stefan M. Gysler*, Grace B. McKenney, Matthew Knarr, Hannah J. Lusk, Priyanka Rawat, Hannah S. Rendulich, Marilyn Mitchell, Dara S. Berger, Jamie S. Moon, Suyeon Ryu, Monica Mainigi, Marcin P. Iwanicki, Dave S. Hoon, Laura M. Sanchez, Ronny Drapkin Norepinephrine induces anoikis resistance in high-grade serous ovarian cancer precursor cells , JCI Insight, 9(5):e170961: 2024

Soledad Henríquez, Maria Jose Valdivia, Monica Mainigi, Claudio Villarroel, Luis Velasquez, Jerome F. Strauss III, Luigi Devoto The role of estrogen metabolites in human ovarian function , Steroids , 203:109368: 2024