Monica A. Mainigi, MD

she/her/hers
Reproductive Endocrinology and Infertility
LGBTQ+ affirming provider
Accepting new patients
Sees patients age 4 to 65
Penn Fertility Care
Headshot of Monica A. Mainigi, MD
Penn Medicine Provider

About me

  • Program Director, Fellowship in Reproductive Endocrinology and Infertility
  • Associate Professor of Obstetrics and Gynecology at the Hospital of the University of Pennsylvania

My education and training

  • Medical School: New York University School of Medicine
  • Residency: University of Pennsylvania Health System
  • Fellowship: University of Pennsylvania Health System

Spoken languages

English
English
हिन्दी
Hindi

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Lancaster General Hospital: Has privileges to treat patients in the hospital.
  • Princeton Medical Center: Has privileges to treat patients in the hospital.
Dr. Mainigi is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Lee IT, Koelper N, Mainigi M, Berger DS, Senapati S. Racial/ethnic variation in ovarian responsiveness and live birth after in vitro fertilization. , Fertil Steril., Online ahead of print: 2026


Merlino MS, Barksdale B, Negatu SG, Clements RL, Miller-Ensminger T, Lopez AH, Mani S, Mainigi M, Hunter CA, Jurado KA. Interleukin-27 is antiviral against Zika virus at the maternal-fetal interface. , Nature Communication, 17(1):652: 2025


Mani S, Kim S, Flock R, Huh D, Mainigi M Microfluidic organ-on-chip device: a unique platform for investigating implantation and placentation , Fertil Steril , 124(6): 2025,1162-1177


Pollie MP, Peipert B, Kim S, Mainigi MA. Isolated Inhibin-Producing Granulosa Cell Tumor Causing Primary Amenorrhea: A Case Report. , J Pediatr Adolesc Gynecol, 38(4): 2025,532-536


Thea N Golden, Sneha Mani, Rebecca L Linn, Rita Leite, Natalie A Trigg, Annette Wilson, Lauren Anton, Monica Mainigi, Colin C Conine, Brett A Kaufman, Jerome F Strauss, Samuel Parry, Rebecca A Simmons Extracellular vesicles alter trophoblast function in pregnancies complicated by COVID-19 , J Extracell Vesicles 2025: 2025


Simoni MK, Negatu SG, Park JY, Mani S, Arreguin MC, Amses KR, Huh DD, Mainigi M*, Jurado KA* Type I interferon exposure of an implantation-on-a-chip device alters invasive extravillous trophoblast function. , Cell Rep Med. , 6(3):101991: 2025


Leigh A Humphries, Jeremy Applebaum, Monica A Mainigi, Caitlin E Martin, Divya K Shah Predicting a successful match among applicants to reproductive endocrinology and infertility fellowship. , Fertility and Sterility , 123(2): 2025,333-341


Chen X, Tober J, Dominguez M, Tang AT, Bockman J, Yang J, Mani S, Lee CN, Chen M, Thillaikumaran T, Mericko-Ishizuka P, Mainigi M, Speck NA, Kahn ML. Lineage tracing studies suggest that the placenta is not a de novo source of hematopoietic stem cells. , PLoS Biol. , 23(1):e3003003: 2025


Leigh A Humphries, Jeremy Applebaum, Monica A Mainigi, Caitlin Martin, Divya K Shah Predicting a successful match among applicants to reproductive endocrinology and infertility fellowship , Fertil Steril , Epub: 2024


Sneha Mani, James Garifallou, Se-jeong Kim, Michael K. Simoni, Dan Dongeun Huh, Scott M. Gordon and Monica Mainigi Uterine macrophages and NK cells exhibit population and gene-level changes after implantation but maintain pro-invasive properties , Frontiers in Immunology, 15:1364036: 2024