Mitchell A. Lazar, MD, PhD
Headshot of Mitchell A. Lazar, MD, PhD
Penn Medicine Provider

About me

  • Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
  • Professor of Medicine in Genetics

Education and training

  • Medical School: Stanford University School of Medicine
  • Residency: Mass General Brigham Healthcare Center - Chestnut Hill
  • Fellowship: Massachusetts General Hospital

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
Dr. Lazar is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Chini J, DeMarco N, Mitchell DV, McCright SJ, Shen KM, Pandey D, Clement RL, Miller J, Jain R, Taylor DM, Lazar MA, Hill DA. D9 regulates macrophage-mediated remodeling of adipose tissue in obesity. , JCI Insight, 11(6): 2026,e193837


Cassim Bawa FN, Lazar MA. Nuclear receptor coregulator interactions: beyond the switch. , Genes Dev., 40(3-4): 2026,146-159


Nadarajah CJ, Li MY, Quillin EI, Boyer K, Dimitry JM, Chen Y, King MW, Saliu IO, Lee J, Sheehan PW, Davis AA, Lazar MA, Zhao G, Musiek ES. REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function. , Proc Natl Acad Sci U S A., 123(5): 2026,e2511093123


Lee J, Kang R, Park S, Saliu IO, Son M, Voorhees JR, Dimitry JM, Quillin EI, Woodie LN, Lananna BV, Gan L, Goo YA, Zhao G, Lazar MA, Burris TP, Musiek ES. REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3-CD38 axis. , Nat Aging. , 5(10): 2025,2070-2085


Hu W, Zhu B, He N, Xiao Y, Chen B, Li C, Mandla R, Liu Y, Zhang J, Chang X, Yu F, Vujkovic M, Lynch J, Chang KM; VA Million Veteran Program; Pasaniuc B, Rader D, Lazar MA. Integrative functional genomics reveals transcriptional regulatory function of risk alleles for metabolic liver disease. , Res Sq: 2025,rs.3.rs-6984670


Wang X, Moore MP, Shi H, Xiao Y, Zhang J, Faccioli LAP, Hu Z, Khalid S, Saleheen D, Stupack DG, Kisseleva T, Soto Gutierrez A, Lazar MA, Tabas I. A non-apoptotic caspase-8-meteorin pathway in hepatocytes promotes MASH fibrosis. , Nat Metab., 7(10): 2025,2067-2082


Tackenberg MC, Heliodoro KM, Melink LC, Liu Y, Zhu K, Lazar MA. Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors. , Cell Rep., 44(10): 2025,116437


Bhattarai B, Antonova AU, Fachi JL, Hopkins LS, McCullen MVD, Saini A, Oliveira S, Beatty WL, Musiek ES, Kuchroo VK, Lazar MA, Oltz EM, Colonna M. Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt. , Nat Immunol, 26(9): 2025,1527-1539


Deota S, Pendergast JS, Kolthur-Seetharam U, Esser KA, Gachon F, Asher G, Dibner C, Benitah SA, Escobar C, Muoio DM, Zhang EE, Hotamışlıgil GS, Bass J, Takahashi JS, Rabinowitz JD, Lamia KA, de Cabo R, Kajimura S, Longo VD, Xu Y, Lazar MA, Verdin E, Zierath JR, Auwerx J, Drucker DJ, Panda S. The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research. , Nat Metab, 7(3): 2025,454-468


Woodie LN, Alberto AJ, Krusen BM, Melink LC, Lazar MA. Genetic synchronization of the brain and liver molecular clocks defend against chrono-metabolic disease. , Proc Natl Acad Sci U S A., 121(51): 2024,e2417678121


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