About me
- Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
- Professor of Medicine in Genetics
Education and training
- Medical School: Stanford University School of Medicine
- Residency: Mass General Brigham Healthcare Center - Chestnut Hill
- Fellowship: Massachusetts General Hospital
My Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
Qualifications and experience
- Internal Medicine, 1985
- American Academy of Arts and Sciences, National
- American Association for the Advancement of Science, National
- American Diabetes Association, National
- American Federation of Medical Research, National
- American Society for Clinical Investigation, National
- American Thyroid Association, National
- Association of American Physicians, National
- Institute of Medicine, National
- National Academy of Sciences, National
- Pfizer, National
- Scientific Advisory Board, Flare Therapeutics, National
- The Endocrine Society, National
Treatments and Conditions
My research
Chini J, DeMarco N, Mitchell DV, McCright SJ, Shen KM, Pandey D, Clement RL, Miller J, Jain R, Taylor DM, Lazar MA, Hill DA. D9 regulates macrophage-mediated remodeling of adipose tissue in obesity. , JCI Insight, 11(6): 2026,e193837
Cassim Bawa FN, Lazar MA. Nuclear receptor coregulator interactions: beyond the switch. , Genes Dev., 40(3-4): 2026,146-159
Nadarajah CJ, Li MY, Quillin EI, Boyer K, Dimitry JM, Chen Y, King MW, Saliu IO, Lee J, Sheehan PW, Davis AA, Lazar MA, Zhao G, Musiek ES. REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function. , Proc Natl Acad Sci U S A., 123(5): 2026,e2511093123
Lee J, Kang R, Park S, Saliu IO, Son M, Voorhees JR, Dimitry JM, Quillin EI, Woodie LN, Lananna BV, Gan L, Goo YA, Zhao G, Lazar MA, Burris TP, Musiek ES. REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3-CD38 axis. , Nat Aging. , 5(10): 2025,2070-2085
Hu W, Zhu B, He N, Xiao Y, Chen B, Li C, Mandla R, Liu Y, Zhang J, Chang X, Yu F, Vujkovic M, Lynch J, Chang KM; VA Million Veteran Program; Pasaniuc B, Rader D, Lazar MA. Integrative functional genomics reveals transcriptional regulatory function of risk alleles for metabolic liver disease. , Res Sq: 2025,rs.3.rs-6984670
Wang X, Moore MP, Shi H, Xiao Y, Zhang J, Faccioli LAP, Hu Z, Khalid S, Saleheen D, Stupack DG, Kisseleva T, Soto Gutierrez A, Lazar MA, Tabas I. A non-apoptotic caspase-8-meteorin pathway in hepatocytes promotes MASH fibrosis. , Nat Metab., 7(10): 2025,2067-2082
Tackenberg MC, Heliodoro KM, Melink LC, Liu Y, Zhu K, Lazar MA. Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors. , Cell Rep., 44(10): 2025,116437
Bhattarai B, Antonova AU, Fachi JL, Hopkins LS, McCullen MVD, Saini A, Oliveira S, Beatty WL, Musiek ES, Kuchroo VK, Lazar MA, Oltz EM, Colonna M. Circadian circuits control plasticity of group 3 innate lymphoid cells by sustaining epigenetic configuration of RORγt. , Nat Immunol, 26(9): 2025,1527-1539
Deota S, Pendergast JS, Kolthur-Seetharam U, Esser KA, Gachon F, Asher G, Dibner C, Benitah SA, Escobar C, Muoio DM, Zhang EE, Hotamışlıgil GS, Bass J, Takahashi JS, Rabinowitz JD, Lamia KA, de Cabo R, Kajimura S, Longo VD, Xu Y, Lazar MA, Verdin E, Zierath JR, Auwerx J, Drucker DJ, Panda S. The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research. , Nat Metab, 7(3): 2025,454-468
Woodie LN, Alberto AJ, Krusen BM, Melink LC, Lazar MA. Genetic synchronization of the brain and liver molecular clocks defend against chrono-metabolic disease. , Proc Natl Acad Sci U S A., 121(51): 2024,e2417678121