Mitchell A. Lazar, MD, PhD

Call 800-789-7366
Headshot of Mitchell A. Lazar, MD, PhD
Penn Medicine Provider

About me

  • Willard and Rhoda Ware Professor in Diabetes and Metabolic Diseases
  • Professor of Medicine in Genetics

My education and training

  • Medical School: Stanford University School of Medicine
  • Residency: Massachusetts General Hospital/Brigham and Women’s Hospital
  • Fellowship: Massachusetts General Hospital

Spoken languages

English
English

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: On the medical staff, but does not have privileges to treat patients in the hospital.
Dr. Lazar is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Zhou Q, Lazar MA You are when you eat: How food synchronizes liver clocks , Sci Adv, 12(30): 2026,eaej7423

Karavaeva I, Basse AL, Trammell SAJ, Hussain MF, Markussen LK, Havelund JF, Isidor MS, Richter HJ, Chubanava S, Deleye Y, Kaiser Z, Shen Y, Neess D, Sass F, Finger F, Muntadas LA, Tandio D, Ma T, Sustarsic EG, Embring H, Kristensen CK, McIntyre RL, Martinez GJ, Husted AS, Emmett MJ, Kipp ZA, Frost M, Jedrychowski MP, van Weeghel M, Majd H, Zhuravleva E, McGarrah RW, Plucinska K, Midha MK, Prokesch A, Cohen P, Granneman JG, Seale P, Houtkooper RH, Hansen JB, Gygi SP, Schwartz TW, Gillum MP, Hinds TD Jr, Soccio RE, White PJ, Kunji ERS, Moritz T, Treebak JT, Mandrup S, Emanuelli B, Kazak L, Færgeman NJ, Lazar MA, Zachary Gerhart-Hines. Mitochondrial carrier SLC25A34 links clock, diet, and temperature control of interorganellar lipid cycling , bioRxiv [Preprint]: 2026

Zhu B, He N, Xiao Y, Chen B, Li C, Mandla R, Liu Y, Zhang J, Chang X, Yu F, Vujkovic M, Lynch JA, Chang KM; VA Million Veteran Program; Pasaniuc B, Rader DJ, Lazar MA, Hu W. Integrative analyses elucidate transcriptional regulatory functions of risk alleles for metabolic liver disease , Nat Genet, 58(6): 2026,1280-1294

Welles JE, Garifallou JP, Gonzalez MV, Santoleri D, Choudhury FK, DeNicola, GM, Martin RW, Jiang C, Kim J, Li G, Aki Y, Chang CJ, Li D, Wells RG, Xiao Y, Zhang J, Lazar MA, Brady DC, Titchenell PM. Reduction in Hepatic Phosphatidylcholine Biosynthesis Promotes MASH Through Copper Deficiency. , bioRxiv [Preprint]: 2026

Chini J, DeMarco N, Mitchell DV, McCright SJ, Shen KM, Pandey D, Clement RL, Miller J, Jain R, Taylor DM, Lazar MA, Hill DA. D9 regulates macrophage-mediated remodeling of adipose tissue in obesity. , JCI Insight, 11(6): 2026,e193837

Cassim Bawa FN, Lazar MA. Nuclear receptor coregulator interactions: beyond the switch. , Genes Dev., 40(3-4): 2026,146-159

Nadarajah CJ, Li MY, Quillin EI, Boyer K, Dimitry JM, Chen Y, King MW, Saliu IO, Lee J, Sheehan PW, Davis AA, Lazar MA, Zhao G, Musiek ES. REV-ERB-alpha and -beta coordinately regulate astrocyte reactivity and proteostatic function. , Proc Natl Acad Sci U S A., 123(5): 2026,e2511093123

Lee J, Kang R, Park S, Saliu IO, Son M, Voorhees JR, Dimitry JM, Quillin EI, Woodie LN, Lananna BV, Gan L, Goo YA, Zhao G, Lazar MA, Burris TP, Musiek ES. REV-ERBα regulates brain NAD+ levels and tauopathy via an NFIL3-CD38 axis. , Nat Aging. , 5(10): 2025,2070-2085

Wang X, Moore MP, Shi H, Xiao Y, Zhang J, Faccioli LAP, Hu Z, Khalid S, Saleheen D, Stupack DG, Kisseleva T, Soto Gutierrez A, Lazar MA, Tabas I. A non-apoptotic caspase-8-meteorin pathway in hepatocytes promotes MASH fibrosis. , Nat Metab., 7(10): 2025,2067-2082

Tackenberg MC, Heliodoro KM, Melink LC, Liu Y, Zhu K, Lazar MA. Normal circadian period length requires repression of Npas2 by REV-ERB nuclear receptors. , Cell Rep., 44(10): 2025,116437

View all publications