- Asthma
- Blood clot in lung
- Pulmonary embolism
- Respiratory failure
- Home ventilator
Michael G. S. Shashaty, MD, MSCE
Pulmonary Medicine
Sees patients age 18 and up
Harron Lung Center - Inpatient Care
Penn Medicine Provider
About me
- Medical Director, Rapid Response, Hospital of the University of Pennsylvania
- Associate Professor of Medicine (Pulmonary, Allergy and Critical Care) at the Hospital of the University of Pennsylvania
My career is focused in critical care medicine, clinical emergencies, and epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI).
Trained in internal medicine, pulmonary diseases, and critical care medicine, I practice clinically in the medical intensive care unit (ICU) and with the Critical Care Outreach and Procedure Service (CCOPS) at the Hospital of the University of Pennsylvania (HUP). I am the CCOPS service lead and Rapid Response Medical Director at HUP, working with a multidisciplinary team to provide oversight, to design and conduct training, and to pursue quality improvement initiatives in clinical emergencies and bedside procedures. Our team also conducts research designed to better recognize and rescue non-ICU inpatients with incipient critical illness.
I am the principal investigator of the Lung Transplant Outcomes Group–Acute Kidney Injury (LTOG-AKI) study, a multicenter prospective cohort of lung transplant recipients (n>1900) designed to study the clinical and molecular epidemiology of post-lung transplant AKI. The primary focus of this study is to determine clinical characteristics and novel blood and urine biomarkers that are useful for AKI prediction and may provide insight into molecular mechanisms of AKI after transplantation.
I am also the principal investigator for the ongoing Penn Trauma Organ Dysfunction Study (PETROS), a cohort of critically ill trauma patients (n>1400), and a co-investigator in Penn’s Molecular Epidemiology of Sepsis in the ICU (MESSI) cohort, for which I lead studies of AKI. Current areas of study in these cohorts include elucidating mechanisms underlying the association of obesity and AKI, circulating cell-free DNA as a mechanistic contributor to AKI and ARDS, genetic risk factors for AKI, and.drug nephrotoxicity in critical illness.
These research and clinical efforts are supported by a large number of outstanding mentors, colleagues, mentees, and trainees with whom I have the great fortune to work and from whom I am constantly learning.
My education and training
- Vanderbilt University Medical CenterMedical School
- University of Pennsylvania Health SystemResidency
- University of Pennsylvania Health SystemFellowship
Spoken languages
English
English
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
- Aetna Advantra Cares D-SNP
- Aetna Advantra Credit Value
- Aetna Advantra Eagle HMO
- Aetna Advantra Eagle POS
- Aetna Advantra Premier Plus PPO
- Aetna Advantra Value
- Aetna Advantra Value Plus
- Aetna APCN Plus (Multi-Tier)
- Aetna Better Health Kids (CHIP) - DH Only
- Aetna Flexible Five
- Aetna Freedom Core
- Aetna Gold
- Aetna HMO
- Aetna Philly Prime
- Aetna POS
- Aetna PPO APCN
- Aetna Premier
- Aetna Premier Plus
- Aetna Savings Plus
- Aetna Signature Administrators
- Aetna Student Health Plan PPO
- Aetna Upfront Advantage
- First Health HMO
- First Health POS
- First Health PPO
- Meritain - Aramark (Other)
- Meritain - Aramark (Pennsylvania Premier Medical Plan)
- Americhealth Caritas of PA VIP - LGH Only
- Amerihealth Caritas (Transplant patients only)
- Amerihealth Caritas of PA - LGH Only
- Centivo EPO
- Cigna Healthcare EPO
- Cigna Healthcare HMO
- Cigna Healthcare POS
- Cigna Healthcare PPO
- Claim Watcher (Homestead/ INDECs) Open Access
- Clover Health Choice
- Clover Health Choice Value PPO
- Clover Health Classic HMO
- Clover Health Value
Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
- Penn Medicine Rittenhouse Long-Term Acute Care Hospital
- Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
- Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. Shashaty is a Penn Medicine physician.
Qualifications and experience
- Critical Care Medicine, 2012
- Pulmonary Disease, 2010
- American Thoracic Society, International
- International Society for Heart and Lung Transplantation, International
- NIH ARDS, Pneumonia, and Sepsis Consortium, National
- Society of Critical Care Medicine, International
- Pulmonary vascular disease care
Treatments and conditions
Research
Publications
Brotman CHW, Kennelly M, Hull C, Walling C, Shashaty M, Hsu JY, Negoianu D, Dember LM. Changes in Central Venous Oxygen Saturation during Inpatient Hemodialysis , Blood Purif: 2026
Anderson MR, Gallop R, Localio AR, Oyster M, Kalman L, Griffiths S, Hartwig M, Snyder LD, Shashaty M, Ahya V, Crespo M, Biscotti M, Mezochow G, Pandya K, Gasior J, Calabrese D, Greenland JR, Benvenuto L, Dhillon G, Combs MP, McDyer J, Hage C, Roe D, Shah P, Merlo C, Singer JP, Palmer SM, Christie JD. Re-evaluating the role of oxygen delivery and radiographs in the definition of primary graft dysfunction after lung transplantation: A Lung Transplant Outcomes Group cohort study , J Heart Lung Transplant: 2026
Giannini HM, Kan M, Cosgriff CV, Morley MP, Miano TA, Narayanan N, Ittner CAG, Turner AP, Esperanza MP, Erlich MC, Oniyide O, Anderson BJ, Jones TK, Feng R, Reilly JP, Himes BE, Shashaty MGS, Meyer NJ. Whole blood transcriptomics reveals sepsis mortality-associated changes in neutrophil degranulation , Am J Respir Cell Mol Biol, 74: 2026,949-960
Self WH, Calfee CS, Brown SM, Moss M, Ware LB, Hyzy RC, Meyer NJ, Reilly JP, Harhay MO, Shashaty MGS, Sandsmark DK, Auriemma CL, Jones TK, Prescott HC, Dickson RP, Nelson K, McSparron JI, Lagina M, Denstaedt SJ, Admon AJ, Patel BK, Wolfe KS, Hite RD, Hudock KM, Bastarache JA, Koyama T, Kerchberger VE, Ely EW, Jackson JC, Sinha P, Mudd PA, Kraft BD, Fremont RD, Singh R, Aggarwal NR, Jolley SE, Burnham EL, Mantelli RA, Janssen WJ, Moore CM, Douglas IS, Peterson R, Peltan ID, Barkauskas CE, Pratt EH, Harris ES, Scharfstein DO, Needham DM, Sahetya SK, Parker AM, Iwashyna TJ, Shenderov K, Matthay MA, Alipanah-Lechner N, Magee L, Shwartzman T, Lin C, Weingart MF, Langelier CR, Chao O, Hendrickson CM, Kornblith LZ, Chak S, Bardillon K, Rodriguez KH, Rogers AJ, Moore AR, Levitt JE, Vojnik R, Perez C, Lindsell CJ, Shotwell MS, Blette BS, Imhoff BW, Rice TW, Rhoads JP, Womack KN, Merkel AR, Ahmad LN, Zhao X, Grandon IE, Gong MN; ARDS, Pneumonia, and Sepsis Consortium. The ARDS, Pneumonia, and Sepsis Consortium: Rationale, Design, and Feasibility of a National Platform for Phenotyping Critical Illness Syndromes , Chest: 2026
Shenoy T, Sanchez-Almanzar D, Dias JA, Hayden R, Shashaty MG, Aklilu AM, Patell R, Anand S, Renaghan A, Bassil C, Neyra JA, Bansal A, Shah CV, Gupta S, Sise ME, Seethapathy R, Chase S, Thompson C, Radhakrishnan R, Verma E, Ni J, Hoge ST, Lypka V, Ali R, Monson AE, Kaunfer S, Angus E, Griffiths S, Walling C, Al Haddad N, Brotman CH, Miano T, Shirali AC, Turco DJ, Alleyne SA, Shelton K, Shaefi S, Garcia D, Nasim A, Jan N, Nguyen PH, Ziolkowski S, Subramanian N, Subramanian V, Debnath N, Faldu CT, Wickramasinghe K, Donahue BP, Shah A, Shostak J, Jayakumar V, Nadayil J, Baz R, Takeuchi T, Renzi S, Rehman AU, Nombera-Aznaran N, Charkviani M, Kotzin M, Kaiser J, Edwards M, Mathavan A, Mathavan A, Obimdike F, Shah N, LaCasce AS, Armand P, Leaf DE. Early treatment with rasburicase and risk of kidney replacement therapy and death in adults with tumour lysis syndrome: emulated target trial , BMJ, 394: 2026,e100040
Bennett RM, Housel KC, Jones TK, Miano TA, Emre G, Turner A, Esperanza M, Erlich M, Ittner C, Shashaty MGS, Meyer NJ, Anderson MR, Christie JD, Reilly JP. Epidemiology of the acute respiratory distress syndrome and the prognostic validity of SpO(2):FiO(2) under the expanded Global definition , Crit Care, 30: 2026,321
Al-Naamani N, Balte P, Shashaty MGS, Sharaf A, Terry JG, Carr JJ, Allison M, Anderson CAM, Bhatt SP, Long MT, Christie JD, Oelsner EC, Anderson MR. CT-adipose measures identify severe SARS-CoV-2 risk beyond traditional obesity metrics: a C4R cohort study , BMC Pulm Med, 26: 2026,326
Bennett RM, Housel KC, Jones TK, Giannini HM, Emre G, Esperanza M, Turner A, Ittner C, Shashaty MGS, Feng R, Anderson MR, Weissman GE, Meyer NJ, Christie JD, Reilly JP. Two Physiologic Latent Classes of Acute Hypoxemic Respiratory Failure in Sepsis Are Distinguished by Lung Mechanics and Gas Exchange , Crit Care Explor, 7: 2025,e1314
Jones TK, Reilly JP, Anderson BJ, Miano TA, Karanam B, Ittner CAG, Shashaty MGS, Feng R, Meyer NJ. Soluble Fms-Like Tyrosine Kinase-1 Associates With Risk of Acute Respiratory Distress Syndrome and Mortality in Sepsis , Crit Care Explor, 7: 2025,e1294
Ronner L, Giannini HM, Miano TA, Ittner CAG, Turner AP, Dunn TG, Agyekum RS, Dasgupta A, West K, Jones TK, Shashaty MGS, Reilly JP, Meyer NJ. Parsimonious Subphenotyping Algorithms Perform Differently in Patients With Sepsis and Hematologic Malignancy , Crit Care Med, 53: 2025,e2415-e2428