Michael G. S. Shashaty, MD, MSCE
Pulmonary Medicine
Sees patients age 18 and up
Harron Lung Center - Inpatient Care
Call 800-789-7366
Penn Medicine Provider

About me

  • Medical Director, Rapid Response, Hospital of the University of Pennsylvania
  • Associate Professor of Medicine (Pulmonary, Allergy and Critical Care) at the Hospital of the University of Pennsylvania

My career is focused in critical care medicine, clinical emergencies, and epidemiologic and translational research studies of the risks for and mechanisms of acute organ dysfunction, primarily acute kidney injury (AKI).

Trained in internal medicine, pulmonary diseases, and critical care medicine, I practice clinically in the medical intensive care unit (ICU) and with the Critical Care Outreach and Procedure Service (CCOPS) at the Hospital of the University of Pennsylvania (HUP). I am the CCOPS service lead and Rapid Response Medical Director at HUP, working with a multidisciplinary team to provide oversight, to design and conduct training, and to pursue quality improvement initiatives in clinical emergencies and bedside procedures. Our team also conducts research designed to better recognize and rescue non-ICU inpatients with incipient critical illness.

I am the principal investigator of the Lung Transplant Outcomes Group–Acute Kidney Injury (LTOG-AKI) study, a multicenter prospective cohort of lung transplant recipients (n>1900) designed to study the clinical and molecular epidemiology of post-lung transplant AKI. The primary focus of this study is to determine clinical characteristics and novel blood and urine biomarkers that are useful for AKI prediction and may provide insight into molecular mechanisms of AKI after transplantation.

I am also the principal investigator for the ongoing Penn Trauma Organ Dysfunction Study (PETROS), a cohort of critically ill trauma patients (n>1400), and a co-investigator in Penn’s Molecular Epidemiology of Sepsis in the ICU (MESSI) cohort, for which I lead studies of AKI. Current areas of study in these cohorts include elucidating mechanisms underlying the association of obesity and AKI, circulating cell-free DNA as a mechanistic contributor to AKI and ARDS, genetic risk factors for AKI, and.drug nephrotoxicity in critical illness.

These research and clinical efforts are supported by a large number of outstanding mentors, colleagues, mentees, and trainees with whom I have the great fortune to work and from whom I am constantly learning.

Education and training

  • Medical School: Vanderbilt University
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital
Dr. Shashaty is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Bennett RM, Housel KC, Jones TK, Giannini HM, Emre G, Esperanza M, Turner A, Ittner C, Shashaty MGS, Feng R, Anderson MR, Weissman GE, Meyer NJ, Christie JD, Reilly JP. Two Physiologic Latent Classes of Acute Hypoxemic Respiratory Failure in Sepsis Are Distinguished by Lung Mechanics and Gas Exchange , Crit Care Explor, 7: 2025,e1314

Jones TK, Reilly JP, Anderson BJ, Miano TA, Karanam B, Ittner CAG, Shashaty MGS, Feng R, Meyer NJ. Soluble Fms-Like Tyrosine Kinase-1 Associates With Risk of Acute Respiratory Distress Syndrome and Mortality in Sepsis , Crit Care Explor, 7: 2025,e1294

Ronner L, Giannini HM, Miano TA, Ittner CAG, Turner AP, Dunn TG, Agyekum RS, Dasgupta A, West K, Jones TK, Shashaty MGS, Reilly JP, Meyer NJ. Parsimonious Subphenotyping Algorithms Perform Differently in Patients With Sepsis and Hematologic Malignancy , Crit Care Med: 2025

Dasgupta A, Jones TK, Giannini H, Bennett R, Emre G, Ittner CAG, Turner A, Esperanza M, Housel K, Miano T, Erlich M, Anderson BJ, Shashaty MGS, Meyer NJ, Reilly JP. Identifying a unique signature of sepsis in patients with pre-existing cirrhosis , Crit Care, 29: 2025,199

Miano TA, Brotman CHW, Scheetz MH, Shashaty MGS. Effect of Pseudonephrotoxicity on Apparent Acute Kidney Injury Incidence and Severity: A Simulation Study , Clin J Am Soc Nephrol, 20: 2024,866-868

Miano TA, Zuppa AF, Feng R, Griffiths S, Kalman L, Oyster M, Cantu E, Yang W, Diamond JM, Christie JD, Scheetz MH, Shashaty MGS. Development and validation of a population pharmacokinetic model to guide perioperative tacrolimus dosing after lung transplantation , JHLT Open, 6: 2024,100134

Schneider ALC, Ginestra JC, Kerlin MP, Shashaty MGS, Miano TA, Herman DS, Mitchell OJL, Bennett R, Moffett AT, Chandler J, Kalanuria A, Faraji Z, Bishop NS, Schmid B, Chen AT, Bowles KH, Joseph T, Kohn R, Kelz RR, Anesi GL, Kumar M, Friedman AB, Vail E, Meyer NJ, Himes BE, Weissman GE. The Complete Inpatient Record Using Comprehensive Electronic Data (CIRCE) project: A team-based approach to clinically validated, research-ready electronic health record data , Learn Health Syst, 9: 2024,e10439

Bennett RM, Reilly JP, Diamond JM, Cantu E, Shashaty M, Benvenuto L, Singer JP, Palmer SM, Christie JD, Anderson MR. Body mass index and mortality following primary graft dysfunction: A Lung Transplant Outcomes Group study , JHLT Open, 5: 2024,100107

Diamond JM, Anderson MR, Cantu E, Clausen ES, Shashaty MGS, Kalman L, Oyster M, Crespo MM, Bermudez CA, Benvenuto L, Palmer SM, Snyder LD, Hartwig MG, Wille K, Hage C, McDyer JF, Merlo CA, Shah PD, Orens JB, Dhillon GS, Lama VN, Patel MG, Singer JP, Hachem RR, Michelson AP, Hsu J, Russell Localio A, Christie JD. Development and validation of primary graft dysfunction predictive algorithm for lung transplant candidates , J Heart Lung Transplant, 43(4): 2024,633-641

Reilly JP, Shashaty MGS, Miano TA, Giannini HM, Jones TK, Ittner CAG, Christie JD, Meyer NJ. ABO Histo-Blood Group and the von Willebrand Factor Axis in Severe COVID-19 , CHEST Crit Care: 2023

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