Matthew C. Brennan, MD
Hematology, Medical Oncology
Accepting new patients
Sees patients age 18 and up
LG Health Physicians Hematology and Medical Oncology
Headshot of Matthew C. Brennan, MD
Penn Medicine Provider

About me

Having practiced medical oncology for over a decade, I’ve had a chance to see exciting breakthroughs and evolving therapeutics that help those affected by cancer live longer and better. 

I practice general medical oncology and benign hematology. My area of additional expertise and interest is genitourinary malignancies—prostate, bladder, kidney, and testicular cancers. Most of the therapies we use today in genitourinary cancers did not exist when I was a student, and I feel optimistic about what the next decade in breakthroughs will bring to the clinic.

I wake up each day excited that I get to be a part of a team at the Ann B. Barshinger Cancer Institute that gets to do great things for the patients we care for. It truly is such an exciting time to be a physician and a privilege to be able to help our community. 

 

Education and training

  • Medical School: Pennsylvania State University College of Medicine
  • Residency: Thomas Jefferson University Hospital
  • Fellowship: Penn State Milton S. Hershey Medical Center

What my patients think about me

Average Rating

218 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
April 2026
very knowledgeable.
Anonymous
March 2026
he was personable and knowledgeable.
Anonymous
March 2026
we really like him
Anonymous
March 2026
knowledgeable,caring and experienced

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Lancaster General Hospital: Has privileges to treat patients in the hospital.
Dr. Brennan is a Penn Medicine Lancaster General Health physician.

Qualifications and experience

Treatments and Conditions