Matthew M. Astolfi, MD, MS
Orthopaedic Surgery
Accepting new patients
Sees patients age 18 and up
Penn Orthopaedics Valley Forge
View 1 additional location
Schedule onlineCall 215-662-3340
Penn Medicine Provider

About me

  • Assistant Professor of Clinical Orthopaedic Surgery

Dr. Astolfi is an orthopaedic surgeon specializing in the treatment of shoulder and elbow conditions. Dr. Astolfi grew up in Corning, New York but moved to the greater Philadelphia area after undergraduate. Prior to medical school, he completed a Master's degree in Exercise Science at the University of Delaware where he also worked as a Certified Athletic Trainer, assisting Division I athletes recover from injuries and return to sport. He completed his medical education at Sidney Kimmel Medical College at Thomas Jefferson University and went onto Orthopaedic Surgery Fellowship at Corewell Health William Beaumont University Hospital, in Royal Oak, Michigan. He was then awarded a fellowship at the Hospital of the University of Pennsylvania in Shoulder and Elbow Surgery. Dr. Astolfi has been the recipient of numerous awards including the Joseph. P. Iannotti Award for Excellence in Shoulder Surgery, was named the Fellow of the Year in 2025 for his commitment to education, and received the prestigious Orthopaedic Research and Education Fund Grant during his residency. He performs a variety of surgical procedures for the shoulder and elbow with a specific focus on treating fractures about the shoulder and elbow, repairing rotator cuff tears, and both anatomic and reverse shoulder replacements for arthritis conditions as well as revision shoulder replacement.

Education and training

  • Medical School: Thomas Jefferson University Sidney Kimmel Medical College
  • Residency: Beaumont Hospital, Royal Oak
  • Fellowship: Hospital of the University of Pennsylvania

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
  • Chester County Hospital: Has privileges to treat patients in the hospital.
Dr. Astolfi is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Brandon Fisher, MD ∙ Matthew Astolfi, MD ∙ Justin DesLaurier, MD ∙ Karen Childers, MS ∙ James Y.J. Lee, MD ∙ Marisa Samani, BA ∙ Madeleine DeClercq, BS ∙ J. Michael Wiater, MD Polyethylene wear: an under-reported cause of failed shoulder arthroplasty , JSES International: 2025

Monir JG, Astolfi MM, Sholder D, Kocovic N, Horneff JG 3rd, Abboud JA, Schoch BS. Early revision rotator cuff repair: an analysis of outcomes and function , Eur J Orthop Surg Traumatol, 33(2): 2023,321-326.

Hill BW, Singh AM, Astolfi M, Horneff JG, Schoch BS, Abboud JA. Outcomes of rotator cuff repair with concurrent microfracture of focal glenohumeral osteoarthritis , J Shoulder Elbow Surg, 30(7S): 2021,S66-S70

Morrissey PB, Murphy H, Astolfi MM, Sandhu H, Vaccaro AR. Surgical Decision Making for Thoracolumbar Spine Injuries in Polytrauma Patients , Instr Course Lect, 67: 2018,353-368

Astolfi MM, Millhouse P, Murphy H, Schroeder G, Vaccaro AR Thoracolumbar Fracture Classifications: Pros and Cons of the TLICS and AOSpine Classification Systems , Contemporary Spine Surgery, 17(1): 2018,1-8

Bishop M, Astolfi M, Padegimas E, DeLuca P, Hammoud S. Venous Thromboembolism Within Professional American Sport Leagues , Orthop J Sports Med, 5(12): 2017,doi: 10.1177/2325967117745530.

Schroeder GD, Astolfi MM, Hollern DA, Vaccaro AR Understanding the Business Challenges for a Spine Practice in the Changing Healthcare Environment , Contemporary Spine Surgery, 17(7): 2016,1-5

Astolfi MM, Struminger AH, Royer TD, Kaminski TW, Swanik CB. Adaptations of the Shoulder to Overhead Throwing in Youth Athletes , J Athl Train, 50(7): 2015,726-732

Astolfi M, McGuire K, Kaminski TW. The effectiveness of autologous conditioned serum in the treatment of knee osteoarthritis , J Sport Rehabil, 23(4): 2014,365-369