Marco Ruella, MD
Penn Medicine Provider

About me

  • Scientific Director of the Lymphoma Program
  • Associate Professor of Medicine (Hematology-Oncology)
  • Assistant Professor of Medicine in Pathology and Laboratory Medicine

Education and training

  • Medical School: Universita Degli Studi di Torino
  • Residency: University of Turin

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Ruella is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Thomas C, Chung J, Landsburg D, Nasta SD, Svoboda J, Chong E, Schuster S, Carter J, Cook M, Tomasulo E, Elghway O, Lariviere M, Hubbeling H, Plastaras J, Villasenor-Park J, Myers C, Ruella M, Rook A, Kim E, Barta S. Clinical features and outcomes of patients with non-erythrodermic mycosis fungoides with high blood tumor burden. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Knoedler L, Herfeld K, Schaefer DA, Diatta F, Clune J, Evans B, Seu M, Kim BS, Alfertshofer M, Schaschinger T, Iske J, Knoedler S, Lellouch AG, Jeljeli M, Carturan A, Ruella M, Heiland M, Poeck H, Perl M, Pomahac B, Kauke-Navarro M. CAR-T cell therapy and reconstructive oncologic surgery in peripheral solid tumors-A narrative review. , Cell Rep Med, 6(8): 2025


Porazzi P, Pucillo M, Anant Padmanabhan A, Nason S, Zheng Z, Paruzzo L, Ho M, Michener P, Stella F, Imparato A, Susanibar-Adaniya S, Garfall A, Fraietta J, Ruella M. Epigenetic reprogramming via EZH1/2 inhibition enhances T cell-mediated immunotherapies against multiple myeloma. , In Proceedings of 67th American Society of Hematology Annual Meeting: 2025


Svoboda J, Schuster S, Porter D, Cook M, Nasta SD, Landsburg D, Barta S, Ruella M, Chong E, Carter J, Thomas C, Tomasulo E, Frey N, Connor M, Shea J, Cervini A, McConville J, Tongue C, Four M, Marshall A, Hwang WT, Leskowitz R, Gonzalez V, Christensen S, Plesa G, Siegel D, Jadlowsky J, Fraietta J, Levine B, Hexner E, June C. IL18-armored CAR T cells in patients with CLL/SLL and Richter’s transformation after prior BTK inhibitor and venetoclax failure. , In Proceedings of 67th American Society of Hematology Annual Meeting: 2025


Precision targeting of immune-mediated thrombotic thrombocytopenic purpura (iTTP) with chimeric auto-antigen receptor (CAAR) T cells. Khadka R, Cohen I, Parvathaneni K, Lemoine J, Jung S, Bochi-Layec A, Zhao H, Hresko M, Siegel D, Ruella M, Bhoj V. , In Proceedings of 67th American Society of Hematology Annual Meeting: 2025


Han Noll J, Ho M, Paruzzo L, Stella F, Devi P, Ndeupen S, Chen G, Cohen I, Ramierz-Fernandez A, Waxman A, Kapur S, Chen F, Xu R, Huff A, Jarocha D, Patel V, Bochi-Layec A, Ramasubramanian R, Liu S, Bouvier R, Souza V, Patel H, Li Z, Carturan A, Michener P, Hopkins C, Koucky O, Minehart J, Dimitri A, Nabar N, Hasanali Z, Ciccarelli B, Williams E, Bartoszek R, Lavorando M, Mohan S, Gonzalez V, Porazzi P, Bhoj V, Apostolidis S, Vogl D, Porter D, Scholler J, Diorio C, Doto A, Everett J, Bushman F, Nathanson K, Stadtmauer E, Susanibar-Adaniya S, Garfall A, Ruella M, Cohen A, Fraietta J. Delayed neurotoxicity, enterocolitis, and BCMA-CART-associated immune-related adverse events (CirAE) are caused by CD4+ CAR T-cells. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Cohen A, Susaniber-Adaniya S, Garfall A, Vogl D, Kapur S, Waxman A, Zubka D, Hwang WT, Diaczynsky C, Han Noll J, Ho M, Paruzzo L, Bing Y, Xu R, Thai E, Gonzalez V, Michener P, Ruella M, Fraietta J, Stadtmauer E. Phase 2 study of cevostamab consolidation following BCMA CAR T cell therapy: preliminary safety, efficacy, and correlative data from the “STEM” (Sequential T Cell-Engagement for Myeloma) trial. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


Stella F, Schneider M, Paruzzo L, Han Noll J, Devi P, Babatunde V, Chong E, Ho M, Thomas C, Cook M, Hossain N, Carter J, Li Z, Tan M, Michener P, Guruprasad P, Patel V, Imparato A, Carturan A, Lemoine J, Souza V, Porazzi P, Fraietta J, Barta S, Nasta SD, Svoboda J, Schuster SJ, Maillard I, Landsburg D, Ruella M. Naive CD4+ at apheresis and disease control at infusion are associated with improved efficacy in second-line CAR T-cells. , In Proceedings of 67th American Society of Hematology Annual Meeting: 2025


Lemoine J, Cohen I, Croston G, Bochi-Layec A, Espie D, Ramasubramanian R, Porazzi P, Stella F, Bayat P, Jung S, Iatrou Anastasia, Agathangelidis A, Schuster S, Ghia P, Stamatopoulos K, Ruella M. Precision targeting of the malignant clone in B-cell malignancies using chimeric antigen receptor T cells against the clonotypic IGHV3-23 B cell receptor. , In Proceedings of 67th American Society of Hematology Annual Meeting: 2025


Cohen I, Khadka R, Lemoine L, Bochi-Layec A, Jung S, Kim KH, Zhao H, Hresko M, Siegel D, Ghia P, Stamatopoulos K, Schuster S, Bhoj V, Ruella M. Precision targeting of autoantibody-producing IGHV1-69+ B cells in immune-mediated thrombotic thrombocytopenic purpura (iTTP) using chimeric antigen receptor T cells. , In Proceedings of 67th American Society of Hematology Annual Meeting 2025: 2025


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