Laura Pappalardo, MD, PhD, PharmD
Neurology
Laura Pappalardo, MD, PhD, PharmD
Neurology
Penn Medicine Provider
About me
- Instructor A of Neurology
My education and training
- Yale University School of MedicineMedical School
- University of Pennsylvania Health SystemResidency
- University of Pennsylvania Health SystemFellowship
Spoken languages
English
English
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
- Aetna Advantra Cares D-SNP
- Aetna Advantra Credit Value
- Aetna Advantra Eagle HMO
- Aetna Advantra Eagle POS
- Aetna Advantra Premier Plus PPO
- Aetna Advantra Value
- Aetna Advantra Value Plus
- Aetna APCN Plus (Multi-Tier)
- Aetna Better Health Kids (CHIP) - DH Only
- Aetna Flexible Five
- Aetna Freedom Core
- Aetna Gold
- Aetna HMO
- Aetna Philly Prime
- Aetna POS
- Aetna PPO APCN
- Aetna Premier
- Aetna Premier Plus
- Aetna Savings Plus
- Aetna Signature Administrators
- Aetna Student Health Plan PPO
- Aetna Upfront Advantage
- First Health HMO
- First Health POS
- First Health PPO
- Meritain - Aramark (Other)
- Meritain - Aramark (Pennsylvania Premier Medical Plan)
- Amerihealth of NJ Core
- Amerihealth of NJ Enhanced
- Amerihealth of NJ HMO
- Amerihealth of NJ Local Value
- Amerihealth of NJ POS
- Amerihealth of NJ PPO
- Amerihealth of NJ Regional Preferred
- Amerihealth of NJ Secure
- Amerihealth of NJ Ultimate (PPO)
- Centivo EPO
- Cigna Healthcare EPO
- Cigna Healthcare HMO
- Cigna Healthcare POS
- Cigna Healthcare PPO
- Claim Watcher (Homestead/ INDECs) Open Access
- Clover Health Choice
- Clover Health Choice Value PPO
- Clover Health Classic HMO
- Clover Health Value
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
- Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
- Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. Pappalardo is a Penn Medicine physician.
Qualifications and experience
- Neurology, 2024
- American Academy of Neurology, National
- American Neurological Association, National
- International Society for Extracellular Vesicles, International
- National Neurotrauma Society, National
- Neurocritical Care Society, National
- Philadelphia Medical Society, Local
- Society for Neuroscience, National
- Society of Critical Care Medicine, National
- University of Pennsylvania Institute for Translational Medicine and Therapeutics, Local
- Stroke care
Treatments and conditions
Research
Publications
Kauffman A, Carlin PS, Mubeen HK, Georges AP, Pappalardo LW, Augustin DV, Dolle JP, Kaplan LJ, Smith DH, Bass GA, Pascual JL. Antithrombin III alone recapitulates plasma-mediated blood-brain barrier stabilization and neurological recovery after traumatic brain injury [in press]. , J Am Coll Surg: 2026
Yang SJ, Lin AA, Shen H, Pappalardo LW, Spychalski GB, Rosario J, Forsberg LK, Grant KM, Buser JR, Savica R, O'Bryant S, Jones DT, Dickson DW, Reichard RR, Nguyen AT, Meaney DF, Boeve BF, Ross OA, McLean PJ, Issadore D. Microfluidic nanomagnetically isolated neuron- and astrocyte-derived extracellular vesicles to differentiate Lewy body and Alzheimer's disease , NPJ Biosens: 2026
Thomas R, Ghio M, Pappalardo L, Shammassian BH. Fluids, Electrolytes, and Nutrition in the Critically Ill Patient with Neurotrauma , Neurosurg Clin N Am: 2025
Elser H, Pappalardo LW, Gottesman RF, Coresh J, Diaz-Arrastia R, Mosley TH, Kasner SE, Koton S, Schneider ALC. Head Injury and Risk of Incident Ischemic Stroke in Community-Dwelling Adults , Stroke: 2024
Rachel Thomas, Cillian Lynch, Laura W. Pappalardo, Alexa Walter, Nathan Smyk, Danielle Sandsmark, Ramon Diaz-Arrastia Levels of tau phosphorylated at threonine-181 vary with specific lesion types in acute traumatic brain injury , J Neurotrauma: 2023
Pappalardo LW, Samad OA, Liu S, Zwinger PJ, Black JA, Waxman SG. Nav1.5 in astrocytes plays a sex-specific role in clinical outcomes in a mouse model of multiple sclerosis , Glia: 2018
Cao XC, Pappalardo LW, Waxman SG, Tan AM. Dendritic spine dysgenesis in superficial dorsal horn sensory neurons after spinal cord injury , Mol Pain: 2017
Pappalardo LW, Black JA, Waxman SG. Sodium channels in astroglia and microglia , Glia: 2016
Pappalardo LW, Liu S, Black JA, Waxman SG. Dynamics of sodium channel Nav1.5 expression in astrocytes in mouse models of multiple sclerosis , Neuroreport, 25: 2014,1208-15
Pappalardo LW, Samad OA, Black JA, Waxman SG. Voltage-gated sodium channel Nav 1.5 contributes to astrogliosis in an in vitro model of glial injury via reverse Na+ /Ca2+ exchange , Glia: 2014