About me

Professor of Orthopaedic Surgery
Associate Professor of Orthopaedic Surgery in Neurosurgery

Spoken languages

English

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Dr. Smith is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Bhadouria N, Gawri R, Graziani G, Anderson DE, Chee AV, Dahia CL, Diwan A, Giers MB, Illien-Junger S, Kirilusha A, Nuckley DJ, Rosenzweig DH, Séguin C, Sheyn D, Teixeira GQ, Alini M, Ito K, Mauck RL, Sakai D, Bailey J, Fields AJ, Grad S, Gullbrand SE, Holguin N, Kandel R, Li Z, Li J, Martin JT, Mwale F, O'Connell GD, Purmessur D, Vo N, Zehra U, Chahine NO, Haglund L, Hoyland JA, Le Maitre CL, Lotz JC, Risbud MV, Smith LJ, Tang S, Iatridis JC, Wuertz-Kozak K, Samartzis D A Decade of Leadership and Impact: Celebrating 10 Years of the ORS Spine Section , JOR Spine, 9(2): 2026,e70180

Maparu AK, Rajagopal K, Iyer K, Mauck RL, Smith LJ Preconditioning Mesenchymal Stem Cells to Enhance Performance in the Degenerate Nucleus Pulposus , Tissue Engineering Part B Reviews, In press: 2026

Dahia CL, Smith LJ, Risbud MV, Gantenbein B Advancing Basic and Preclinical Spine Research: Highlights from the ORS PSRS 7th International Spine Research Symposium , JOR Spine, 9(1): 2026,e70161

Gu BJ, Rajagopal K, Malhotra NR, Mauck RL, Schipani E, Smith LJ HIF Prolyl Hydroxylase Inhibition Enhances Healthy Extracellular Matrix Production by Nucleus Pulposus Cells , Orthopaedic Research Society Annual Meeting, Charlotte, USA: 2026

Rajagopal K, Iyer K, Zhang D, Molony CM, Casal ML, Smith LJ In vitro evaluation of therapeutic beta-glucuronidase enzyme uptake and penetration in articular cartilage , WORLD Symposium on Lysosomal Diseases, San Diego, USA: 2026

Iyer K, Fazelinia H, Spruce L, Deng C, Wang M, Nesom G, Link K, Madden R, Gonzalez M, Fajgenbaum D, Ficicioglu C, Smith LJ Comparative Proteomic Analysis of Saliva, Urine, and Serum in Mucopolysaccharidosis I Patients , WORLD Symposium on Lysosomal Diseases, San Diego, USA: 2026

Rajagopal K, Schaer TP, Zhang C, Meadows KD, Hilliard R, O'Donnell JC, Dodge GR, Petrov D, Elliott DM, Mauck RL, Smith LJ*, Malhotra NR*. *Co-corresponding authors. In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration , JOR Spine, 8(2): 2025,e70076

Smith LJ, Campbell R, Smith E, Lutz E, Molony CM, Casal ML Postnatal Progression of Skeletal Disease in Mucopolysaccharidosis VI Dogs: Preliminary Findings , WORLD Symposium on Lysosomal Diseases, San Diego USA: 2025

Rajagopal K, Swingle KL, Iyer K, Jiang Z, Smith E, Molony CM, Dodge GR, Volk SW, Casal ML, Mitchell MJ, Smith LJ In vitro development and in vivo evaluation of intra-articular GUSB mRNA therapy for mucopolysaccharidosis VII , WORLD Symposium on Lysosomal Diseases, San Diego, USA: 2025

Maparu AK, Iyer K, Rajagopal R, Siddiqui Z, Campbell R, Molony CM, Volk SW, Mauck RL, Casal ML, Mitchell MJ, Smith LJ Porous microcarriers for sustained delivery of mRNA-lipid nanoparticles to treat joint disease in the mucopolysaccharidoses , WORLD Symposium on Lysosomal Diseases, San Diego, USA: 2025

Lachlan J. Smith, PhD