Penn Medicine Provider

About me

  • Associate Professor of Orthopaedic Surgery
  • Associate Professor of Orthopaedic Surgery in Neurosurgery

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My research

Rajagopal K, Swingle KL, Iyer K, Jiang Z, Smith E, Molony CM, Dodge GR, Volk SW, Casal ML, Mitchell MJ, Smith LJ In vitro development and in vivo evaluation of intra-articular GUSB mRNA therapy for mucopolysaccharidosis VII , WORLD Symposium on Lysosomal Diseases: 2025


Smith LJ, Campbell R, Smith E, Lutz E, Molony CM, Casal ML Postnatal Progression of Skeletal Disease in Mucopolysaccharidosis VI Dogs: Preliminary Findings , WORLD Symposium on Lysosomal Diseases: 2025


Maparu AK, Iyer K, Rajagopal R, Siddiqui Z, Campbell R, Molony CM, Volk SW, Mauck RL, Casal ML, Mitchell MJ, Smith LJ Porous microcarriers for sustained delivery of mRNA-lipid nanoparticles to treat joint disease in the mucopolysaccharidoses , WORLD Symposium on Lysosomal Diseases: 2025


Rajagopal K, Schaer TP, Zhang C, Meadows KD, Hilliard R, O'Donnell JC, Dodge GR, Petrov D, Elliott DM, Mauck RL, Smith LJ*, Malhotra NR*., *Co-corresponding authors. In Vivo Measurements Reveal Increased Nucleus Pulposus Lactate and Oxygen Concentrations in a Goat Model of Intervertebral Disc Degeneration , JOR Spine: 2025


Chakraborty LS, Le Maitre CL, Chahine NO, Fields AJ, Gawri R, Giers MB, Smith LJ, Tang SY, Zehra U, Haglund L, Samartzis D, Martin JT Impact of the COVID-19 Pandemic on the Productivity and Career Prospects of Musculoskeletal Researchers , Journal of Orthopaedic Research, 42(10): 2024,2296-2306


Lau YK, Iyer K, Friday C, Shetye S, Hast ME, Dodge GR, Casal ML, Gawri R, Smith LJ Evaluation of Tendon and Ligament Microstructure and Mechanical Properties in a Canine Model of Mucopolysaccharidosis I , Journal of Orthopaedic Research, 47(7): 2024,1409-1419


Arginteanu T, Gallagher RS, Borja AJ, Glauser G, Smith LJ, Pasha S, DeTurck D, Malhotra NR Quantifying a novel three-dimensional marker of scoliosis , Spine Deformity, 12(1): 2024,231-237


Zhang C, Zhong L, Lau YK, Wu M, Yao L, Schaer TP, Mauck RL, Malhotra NR, Qin L, Smith LJ Single Cell RNA Sequencing Reveals Emergent Notochord-Derived Cell Subpopulations in the Postnatal Nucleus Pulposus , FASEB Journal, 38(1): 2024,e23363


Smith LJ, Rajagopal K, Laslow B, Wang D, Schipani E In Vivo Regulation of Nucleus Pulposus Cell Differentiation and Extracellular Matrix Elaboration by HIF Prolyl Hydroxylases , 70th Annual Meeting, Orthopaedic Research Society, Long Beach, USA: 2024


Maparu AK, Iyer K, Siddiqui Z, Rajagopal K, Kim J, Mauck RL, Mitchell MJ, Smith LJ A Novel Porous Microcarrier for Extended Release of mRNA-Lipid Nanoparticles for Musculoskeletal Tissue Repair , 70th Annual Meeting, Orthopaedic Research Society, Long Beach, USA : 2024