Kyra O'Brien, MD, MSHP
Neurology
Accepting new patients
Sees patients age 18 and up
Penn Memory Center
Make an appointmentCall 215-662-7810
Penn Medicine Provider

About me

  • Assistant Professor of Neurology at the Hospital of the University of Pennsylvania

Education and training

  • Medical School: University of Pennsylvania School of Medicine
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

What my patients think about me

Average Rating

257 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

October 2025
made a lot of effort
September 2025
the interaction was positive
September 2025
thorough in examination and listened to questions intently.
September 2025
empathetic and positive approach to my situation.

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. O'Brien is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Sydney Pugh, Matthew Hill, Sy Hwang, Rachel Wu, Kuk Jang, Stacy Iannone, Karen O’Connor, Kyra O’Brien, Eric Eaton, Kevin Johnson WATCH-SS: A Trustworthy and Explainable Modular Framework for Detecting Cognitive Impairment from Spontaneous Speech , Pacific Symposium on Biocomputing: 2026

Kyra O'Brien and Jason Karlawish Alzheimer’s Disease: New Diagnostic Technologies and Treatments - The Role of Neuroimaging in Diagnosis of Alzheimer Disease , American Geriatrics Society: 2025

Kyra O’Brien, Wheeler Maxwell, Stacy Iannone, Jason Karlawish, Joseph Teel, Robert Burke Implementation of an Electronic Health Record-Integrated Cognitive Assessment Pathway in Primary Care , Poster session presented at the 2025 Patient-Centered Outcomes Research Institute Annual Meeting, Washington, DC: 2025

Nessen SJ, Chary AN, Bhananker AR, Muir KJ, Southerland LT, O'Brien K, and Friedman AB NOTICE-ED: Nurse or Technician Insights Into Cognitive Evaluations in the Emergency Department , Journal of the American Geriatrics Society , 73(8): 2025,2503-2511

Cameron Coykendall, Megan Zhang, Abigail Perelman, Kristin Harkins, Jason Karlawish, Kyra O'Brien Study of the Utility and Impact of Plasma p-tau181 Alzheimer's Biomarkers - SUIT-ABLE: Patient and Care Partner Outcomes , Poster session presented at the 2025 Association International Conference, Toronto, Canada: 2025

Kyra O'Brien, Emily Largent, Jason Karlawish Communicating a Diagnosis of Mild Cognitive Impairment or Dementia , JAMA: 2025

Kyra O'Brien, Robert E. Burke, Debra Saliba An Elusive Ideal - Why a Pragmatic 'Home Time' Quality Measure Remains Hard to Define , Journal of the American Geriatrics Society: 2025

Megan Zhang, Abigail Perelman, Cameron Coykendall, Kristin Harkins, Jason Karlawish, Kyra O'Brien Study of the Utility and Impact of Plasma p-tau181 Alzheimer's Biomarkers - SUIT-ABLE: Clinical Care Outcomes , Poster session presented at the 2025 Association International Conference, Toronto, Canada: 2025

Kyra O'Brien, Wheeler Maxwell, Stacy Iannone, Jason Karlawish, Joseph Teel, Robert Burke Building a cognitive screening and assessment pathway for primary care: The experience of one health care system , Poster session presented at the 2025 Association International Conference, Toronto, Canada: 2025

O'Brien K, Harkins K, Peifer M, Kleid M, Coykendall C, Shea J, Karlawish J, Burke R Designing an Intervention to Improve Cognitive Evaluations in Primary Care , Implementation Science Communications, 6(1): 2025,9