Penn Medicine Provider
Neurology
Kyra O'Brien, MD, MSHP
4.9
(241)
Accepting new patients
Sees patients age 18 and up
Penn Memory Center
Make an appointmentCall 215-662-7810

About me

  • Assistant Professor of Neurology at the Hospital of the University of Pennsylvania

Education and training

  • Medical School: University of Pennsylvania School of Medicine
  • Residency: Hospital of the University of Pennsylvania
  • Fellowship: Hospital of the University of Pennsylvania

What my patients think about me

Average Rating
4.9

241 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

August 2025
5.0
5.0
complete confidence in my provider. she has earned my trust, which is not easy.
August 2025
5.0
5.0
she was exceptionally knowledgeable and offered to follow up regarding options for support.
August 2025
5.0
5.0
she is patient and spends as much time as needed.
August 2025
5.0
5.0
excellent customer service!!

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. O'Brien is a Penn Medicine physician.

Qualifications and experience

My research

Nessen SJ, Chary AN, Bhananker AR, Muir KJ, Southerland LT, O'Brien K, and Friedman AB NOTICE-ED: Nurse or Technician Insights Into Cognitive Evaluations in the Emergency Department , Journal of the American Geriatrics Society , 73(8): 2025,2503-2511

Kyra O'Brien, Robert E. Burke, Debra Saliba An Elusive Ideal - Why a Pragmatic 'Home Time' Quality Measure Remains Hard to Define , Journal of the American Geriatrics Society: 2025

Kyra O'Brien, Emily Largent, Jason Karlawish Communicating a Diagnosis of Mild Cognitive Impairment or Dementia , JAMA: 2025

O'Brien K, Harkins K, Peifer M, Kleid M, Coykendall C, Shea J, Karlawish J, Burke R Designing an Intervention to Improve Cognitive Evaluations in Primary Care , Implementation Science Communications, 6(1): 2025,9

Erickson C, Largent EA, O'Brien K Paving the way for Alzheimer’s blood-based biomarkers in primary care , Alzheimer's & Dementia: 2024

O'Brien K, Largent E A., Karlawish J Applying recommendations for diagnostic disclosure of mild cognitive impairment and dementia: Practical guidance for clinicians , Alzheimer's & Dementia: 2024

O’Brien, K.S., Mechanic-Hamilton, D.J., Rascovsky, K., Hamilton, R.H Degenerative Disorders of Cognition , Achieving Equity in Neurological Practice: Principles and Pathways: 2024,71-89

Cousins KAQ, Phillips JS, Das SR, O'Brien K, Tropea TF, Chen-Plotkin A, Shaw LM, Nasrallah IM, Mechanic-Hamilton D, McMillan CT, Irwin DJ, Lee EB, Wolk DA Pathologic and cognitive correlates of plasma biomarkers in neurodegenerative disease , Alzheimer's & Dementia, 20(6): 2024,3889-3905

Kyra O’Brien MD, Kristin Harkins MPH, MaryAnne Peifer MD MSIS, Melanie Kleid, Cameron Coykendall, Robert Burke MD MS, Judy Shea PhD, Jason Karlawish MD Clinician-reported factors influencing performance of cognitive evaluations in primary care , Poster session presented at the 2024 American Academy of Neurology Annual Meeting, Denver, CO: 2024

O'Brien K, Coykendall C, Kleid M, Harkins K, Chin N, Clapp JT, Karlawish J Determinants of Plasma Alzheimer’s Disease Biomarker Use by Primary Care Providers and Dementia Specialists , Journal of General Internal Medicine, 39(9): 2024,1713-1720