Kenneth S. Shindler, MD, PhD

Ophthalmology
Accepting new patients
Sees patients age 18 and up
Scheie Eye Institute Penn Presbyterian
Make an appointmentCall 215-662-8100
Headshot of Kenneth S. Shindler, MD, PhD
Penn Medicine Provider

About me

  • F.M. Kirby Professor of Molecular Ophthalmology
  • Professor of Neurology

My education and training

  • Medical School: Washington University School of Medicine
  • Residency: Penn Presbyterian Medical Center
  • Residency: Scheie Eye Institute
  • Fellowship: Scheie Eye Institute

Reviews

Average Rating

149 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
April 2026
dr. Shindler has been very helpful in my treatment and getting me where i am today
Anonymous
April 2026
very complete
Anonymous
April 2026
dr shindler was extremely knowledgeable, forthright, patient and kind.
Anonymous
April 2026
dr shindler explained my diagnosis's better than i had heard from other doctors before.

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Shindler is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

Research

Publications

Alhadi SA, Camacho D, Chaqour B, Rossman JB, Pham JC, Shindler KS, Ross AG. Neuroprotective effects of SIRT1 in human RGCs derived from iPSCs following oxidative stress induction at early and late stages of differentiation. , Exp. Eye Res. , 259: 2025,110526

Kwok A, Chaqour B, Khan RS, Aravand P, Dine K, Ross AG, Shindler KS Pharmacological Activation and Transgenic Overexpression of SIRT1 Attenuate Traumatic Optic Neuropathy Induced by Blunt Head Impact , Transl. Vis. Sci. Technol., 13: 2024,27

Chaqour B, Duong TT, Yue J, Liu T, Camacho D, Dine KE, Esteve-Rudd J, Ellis S, Bennett J, Shindler KS, Ross AG. AAV2 vector optimization for retinal ganglion cell-targeted delivery of therapeutic genes. , Gene Ther., 31: 2024,175-186

Yue J, Khan RS, Duong TT, Dine KE, Cui QN, O'Neill N, Aravand P, Liu T, Chaqour B, Shindler KS, Ross AG. Cell-Specific Expression of Human SIRT1 by Gene Therapy Reduces Retinal Ganglion Cell Loss Induced by Elevated Intraocular Pressure. , Neurotherapeutics. , 20: 2023,896-907

Shamsher E, Khan RS, Davis BM, Dine K, Luong V, Somavarapu S, Cordeiro MF, Shindler KS. Nanoparticles Enhance Solubility and Neuroprotective Effects of Resveratrol in Demyelinating Disease. , Neurotherapeutics., 20: 2023,1138-1153

Ross AG, Chaqour B, McDougald DS, Dine KE, Duong TT, Shindler RE, Yue J, Liu T, Shindler KS Selective Upregulation of SIRT1 Expression in Retinal Ganglion Cells by AAV-Mediated Gene Delivery Increases Neuronal Cell Survival and Alleviates Axon Demyelination Associated with Optic Neuritis , Biomolecules, 12: 2022,830

Saadi F, Chakravarty D, Kumar S, Kamble M, Saha B, Shindler KS, Das Sarma J CD40L protects against mouse hepatitis virus-induced neuroinflammatory demyelination , PLoS Pathog., 17: 2021,e1010059

McDougald DS, Dine KE, Zezulin AU, Bennett J, Shindler KS SIRT1 and NRF2 Gene Transfer Mediate Distinct Neuroprotective Effects Upon Retinal Ganglion Cell Survival and Function in Experimental Optic Neuritis , Invest. Ophthalmol. Vis. Sci., 59: 2018,1212-1220

Grinblat GA, Khan RS, Dine K, Wessel H, Brown L, Shindler KS RGC Neuroprotection Following Optic Nerve Trauma Mediated By Intranasal Delivery of Amnion Cell Secretome , Invest. Ophthalmol. Vis. Sci. , 59: 2018,2470-2477

Khan RS, Dine K, Bauman B, Lorentsen M, Lin L, Brown H, Hanson LR, Svitak AL, Wessel H, Brown L, Shindler KS Intranasal Delivery of A Novel Amnion Cell Secretome Prevents Neuronal Damage and Preserves Function In A Mouse Multiple Sclerosis Model , Sci. Rep., 7: 2017,41768

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