Kenneth B. Margulies, MD
Cardiology

Kenneth B. Margulies, MD

he/his
Cardiology
Accepting new patients
Sees patients age 18 and up
Penn Heart and Vascular Center
Penn Medicine Provider

About me

  • Research Director, Heart Failure/Transplantation
  • Director, Cardiology Clinical Research Unit
  • Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
  • Professor of Medicine in Physiology

I am a physician-scientist with a clinical practice focused on Advanced Heart Failure and Transplant Cardiology and Inherited Cardiomyopathies.

My education and training

  • Thomas Jefferson UniversityMedical School
  • Mayo ClinicResidency
  • Mayo ClinicFellowship

Spoken languages

English
English

Reviews

Average Rating

213 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

Anonymous
August 2026
the doctor is a pure professional as always!!!
Anonymous
July 2026
thorough
Anonymous
June 2026
he has made me feel 100% better in my health.
Anonymous
June 2026
excellent doctor

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital
Dr. Margulies is a Penn Medicine physician.

Qualifications and experience

Treatments and conditions

Research

Publications

Stachelek SJ, Hauber EJ, Yang X, Laurence DW, Rusinkevich V, Lu P, Castillero E, Pressly BB, Brady C, Toomey NT, Fishbein I, Martinez A, Karim AM, Jacobson E, Levine D, Cada S, Margulies KB, Bedi KC Jr, Anderson GM, Krieger AM, Pei L, Ferrari G, Levy RJ. Mechano-sensing channels PIEZO1 and PIEZO2 regulate mitral valve serotonin-mediated homeostasis and pathophysiology. , Cardiovasc Res: 2026


Forelli N, Thome T, Eaton DM, Schultz K, Patel J, Bowman CE, Kawakami R, Jung JW, Kuznetsov IA, Li K, Liang JA, Branch K, Brady C, Bedi KC Jr, Yang Y, Koya K, Bouhrira N, Megill E, Kantner DS, Smith LG, MacIntosh CF, Gupta K, Bowman GR, Snyder NW, Edwards J, Margulies KB, Arany Z SGLT2 inhibitors activate pantothenate kinase in the human heart. , Science, 393(6814): 2026


Ekhteraei-Tousi S, Puertas RD, Youness M, Ronda OAHO, Aronsen M, S Espe EK, Melleby AO, Hauge-Iversen IM, Cutsforth E, Li L, Robinson EL, Nordén ES, Sadredini M, Rega F, Bedi KC Jr, Margulies KB, Sipido KR, Sjaastad I, Roderick HL. Single-Nucleus RNA-Seq of Human and Rat Cardiomyocytes Identifies Shared and Distinct Regulators and Features of Aging and Disease. , Aging Dis: 2026


Manandhar S, Wu Y, Pathak T, Margulies KB, Madabhushi A, Peyster EG Differential cardiac remodeling: patterns of cardiomyocyte morphometry in multiple patient conditions. , Cardiovasc Res: 2026


Polhemus DJ, Butt A, Resch C, Tsai K, Batra VA, Yan S, Mulay A, Drachenberg C, Sam F, Goodchild TT, Lefer DJ, Meddeb M, Margulies KB, Bedi KC Jr, Sharma K, Koleini N, Ravandi A, Kass DA. Integrated Myocardial and Plasma Lipidome Across the Human Obesity-Heart Failure Spectrum. , Res Sq: 2026


Vite A, Guo T, Bouhrira N, Eaton DM, Bedi KC Jr, Brady CF, Edwards JJ, Duric B, Uchida K, Olsen C, Dong L, Prosser BL, Arany Z, Margulies KB. Stiffness-induced impairment of GLUT4 trafficking in adult cardiomyocytes. , Cell Rep, 45(7): 2026


Bayer AL, Zambrano MA, Emig R, Sanders E, Smolgovsky S, Wagner N, Bedi KC Jr, Bhave S, Kapur NK, Margulies KB, Asnani A, Alcaide P. STING promotes CD8 T-cell cardiotropism and fibrosis from distinct cellular compartments in doxorubicin cardiomyopathy. , Cardiovasc Res, 122(9): 2026


Hegyi B, Angsutararux P, Chakouri N, Mahling RW, Fossier L, Nguyen HM, Gilhooly S, Almeida VA, Smith CER, Wang L, Ripplinger CM, Martin JL, Ginsburg KS, Bedi KC Jr, Margulies KB, Ben-Johny M, Bers DM. Targeting Arrhythmogenic Late Sodium Current by FHF1A-Derivative FixR in Heart Failure Cardiomyocytes. , Circ Res, 139(2): 2026


Ky B, Liu T, Margulies KB, Mitchell JD, Haas NB, Gareen IF, Thangarajah M, Sicks JD, Domenico C, Narayan VK, Smith AM, Wilcox NS, Mittal K, Rhee JW, Armenian SH, Saphner T, Paul AK, Gartrell BA, Zaha VG, Anari F, Wong RL, Townsend RR, Wagner LI. Cluster Randomized Controlled Trial of Intensive Systolic Blood Pressure Control in Patients With Renal Cell or Thyroid Cancer Receiving VEGFR Tyrosine Kinase Inhibitors: ECOG-ACRIN EAQ191. , Hypertension, 83(7): 2026


Hahn VS, Chaffin M, Simonson B, Jenkin SC, Mulligan AS, Rezaee M, Bedi KC Jr, Margulies KB, Klattenhoff CA, Sharma K, Kass DA, Ellinor PT. Single-Cell Analysis of Human Heart Failure With Preserved Ejection Fraction. , Circ Res, 139(2): 2026


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