Kenneth B. Margulies, MD
he/his
Cardiology
Accepting new patients
Sees patients age 18 and up
Penn Heart and Vascular Center
Penn Medicine Provider

About me

  • Research Director, Heart Failure/Transplantation
  • Director, Cardiology Clinical Research Unit
  • Professor of Medicine (Cardiovascular Medicine) at the Hospital of the University of Pennsylvania
  • Professor of Medicine in Physiology

I am a physician-scientist with a clinical practice focused on Advanced Heart Failure and Transplant Cardiology and Inherited Cardiomyopathies.

Education and training

  • Medical School: Thomas Jefferson University Sidney Kimmel Medical College
  • Residency: Mayo Clinic
  • Fellowship: Mayo Clinic

What my patients think about me

Average Rating

168 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

September 2025
he was professional...nice ..and he cares
September 2025
knowledgeable and helpful doctor.
September 2025
i believe him to be an excellent doctor with a very caring manner.
September 2025
dr m is fantastic

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Medicine Rittenhouse Long-Term Acute Care Hospital
Dr. Margulies is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Guo Z, Ataran A, Ma P, Yu W, Hajirezaei H, Valenzuela Ripoll C, Pedersen LN, Rashidi O, Chan MM, Shen M, Kelley S, Sargazi A, Ozcan M, Lotfinaghsh A, Cho Y, Diab A, Grogan F, Klaas A, Pompian A, Imam A, Lodhi R, Zelleke AB, Kovacs A, Margulies KB, Szymanski J, Sardiello M, Razani B, Asnani A, Kopecky BJ, Signore PE, Yi BA, Basson CT, Ravichandran KS, Prabhu SD, Bergom C, Schilling JD, Lavine KJ, Javaheri A Human Single-Nucleus RNA Sequencing Identifies CD47 as a Therapeutic Target for Doxorubicin-Induced Cardiomyopathy. , Circulation: 2025


Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley R, Palanki R, Musunuru K, Brenner JS, Mitchell MJ, Ferrari VA, Mui BL, Semple SC, Weppler SA, Atluri P, Margulies KB, Weissman D, Muzykantov VR. Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo , Proc Natl Acad Sci USA: 2025


Lateef AH, Bouhrira N, Lee JJ, Vite A, Margulies KB, Corbin EA Micropatterned Magneto-Rheological Elastomers to Drive Changes in Cardiomyocyte Alignment. , J Vis Exp: 2025


Wang Q, Tang TM, Youlton M, Weldy CS, Kenney AM, Ronen O, Hughes JW, Chin ET, Sutton SC, Agarwal A, Li X, Behr M, Kumbier K, Moravec CS, Tang WHW, Margulies KB, Cappola TP, Butte AJ, Arnaout R, Brown JB, Priest JR, Parikh VN, Yu B, Ashley EA Epistasis regulates genetic control of cardiac hypertrophy. , Nat Cardiovasc Res: 2025


Latchman NR, Stevens TL, Bedi KC, Prosser BL, Margulies KB, Elrod JW. Ultrastructure analysis of mitochondria, lipid droplet and sarcoplasmic reticulum apposition in human heart failure. , J Mol Cell Cardiol Plus: 2025


Ochala J, Feng M, Wang Q, Chaami C, Nollet E, Lewis CTA, Hessel AL, Michels M, Bedi KC Jr, Margulies KB, Pinto JR, Campbell KS, Kuster DWD, van der Velden J Heterogeneous Dysregulation of Myosin Super-Relaxation and Energetics in Hypertrophic Cardiomyopathy , Circ Heart Fail: 2025


Tatekoshi Y, Mahmoodzadeh A, Shapiro JS, Liu M, Bianco GM, Tatekoshi A, Camp SD, De Jesus A, Koleini N, De La Torre S, Wasserstrom JA, Dillmann WH, Thomson BR, Bedi KC, Margulies KB, Weinberg SE, Ardehali H Protein O-GlcNAcylation and hexokinase mitochondrial dissociation drive heart failure with preserved ejection fraction. , Cell Metab: 2025


Tan K, Tay D, Tan W, Ng HK, Wong E, Morley MP, Singhera GK, Lee CJM, Jain PR, Tai FL, Hanson PJ, Cappola TP, Margulies KB, Foo R, Loh M. Epigenome-wide association study for dilated cardiomyopathy in left ventricular heart tissue identifies putative gene sets associated with cardiac pathology and early indicators of cardiac risk. , Clin Epigenetics: 2025


Selvaraj S, Karaj A, Chirinos JA, Denney N, Grosso G, Fernando M, Chambers K, Demastus C, Reddy R, Langham M, Kumar D, Maynard H, Pourmussa B, Prenner SB, Cohen JB, Ischiropoulos H, Rickels MR, Poole DC, Church DD, Wolfe RR, Kelly DP, Putt M, Margulies KB, Zamani P Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction. , JACC Heart Fail: 2025


Selvaraj S, Kwee LC, Thompson EJ, He M, Hornik CP, Devore AD, Patel CB, Mentz RJ, Fudim M, Taylor L, Milosovic S, Hurdle M, Cade WT, Ilkayeva O, Muehlbauer MJ, Newgard CB, Kelly DP, Zamani P, Margulies KB, Shah SH Metabolic and Pharmacokinetic Profiling of a Ketone Ester by Background SGLT2 Inhibitor Therapy in HFrEF. , JACC Basic Transl Sci: 2025


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