Karen Marie Puopolo, MD, PhD
she/her/hers
Neonatology and Newborn Services
Independent provider
Accepting new patients
Sees newborns through age 1 month
Neonatology and Newborn Services Pennsylvania Hospital

About me

  • Chief, Section on Newborn Medicine, Pennsylvania Hospital
  • Professor of Pediatrics (Neonatology & Newborn Services) at the Children's Hospital of Philadelphia

Education and training

  • Medical School: Tufts University School of Medicine
  • Residency: Children's Hospital of Boston
  • Fellowship: Children's Hospital of Boston

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. Puopolo is an independent physician who is not employed by Penn Medicine.

Qualifications and experience

Treatments and Conditions

My research

Koebnick C, Mukhopadhyay S, Getahun D, Tartof SY, Xiang AH, Puopolo KM, Sidell MA. The Contributions of delivery mode and intrapartum antibiotic exposure to body mass index among children through 5 years of age , Eur J Obstet Gynecol Reprod Biol, 311: 2025,113984


Carlo WA, Eichenwald EC, Carper BA, Bell EF, Keszler M, Patel RM, Sánchez PJ, Goldberg RN, D'Angio CT, Van Meurs KP, Hibbs AM, Ambalavanan N, Cosby SS, Newman NS, Vohr BR, Walsh MC, Das A, Ohls RK, Fuller J, Rysavy MA, Ghavam S, Brion LP, Puopolo KM, Moore R, Baack ML, Colaizy TT, Baserga M, Osman AF, Merhar SL, Poindexter BB, DeMauro SB, Kumar V, Cotten CM; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Extended Caffeine for Apnea in Moderately Preterm Infants: The MoCHA Randomized Clinical Trial , JAMA, 333(24): 2025,2154-2163


Heisel T, Gonia S, Dillon A, Hoops SL, Al-Ghalith GA, Gohl D, Mukhopadhyay S, Puopolo K, Kennedy P, Sadowsky MJ, Knights D, Johnson AJ, Gerber JS, Gale CA. Gut mycobiome maturation and its determinants during early childhood: a comparison of ITS2 amplicon and shotgun metagenomic sequencing approaches. , Front Microbiol, 16: 2025,1539750


Coggins SA, Tan S, Puopolo KM, Mukhopadhyay S Association of prolonged rupture of membranes with late-onset infections in extremely preterm infants , Pediatric Academic Societies: 2025


Coggins SA, Wade KC, Watt KM, Downes KJ, Puopolo KM. Vancomycin Concentrations in Umbilical Cord Blood After Intrapartum Exposure , Obstet Gynecol, 145(4): 2025,435-438


Faix RG, Laptook AR, Shankaran S, et al.; for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network Whole-Body Hypothermia for Neonatal Encephalopathy in Preterm Infants 33 to 35 Weeks' Gestation: A Randomized Clinical Trial , JAMA Pediatr, 179(4): 2025


Shankaran S, Laptook AR, Guimaraes C, et al. for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network NICHD Magnetic Resonance Brain Imaging Score in Term Infants With Hypoxic-Ischemic Encephalopathy: A Secondary Analysis of a Randomized Clinical Trial , JAMA Pediatr., 179(4): 2025


Coggins SA, Garber SJ, Puopolo KM. Congenital Cytomegalovirus Detection Following Pennsylvania Hearing-Targeted Screening Legislation , Pediatric Academic Societies: 2025


Flannery DD, Dudley E, Mukhopadhyay S, Zevallos Barboza A, Weissman S, Puopolo KM SIREN: Surveillance of Invasive and Resistant E. coli in Neonates. Pediatric Academic Societies annual meeting Apr 2025. , Pediatric Academic Societies: 2025


May MF, Flannery DD, Puopolo KM, Mukhopadhyay S, Zevallos Barboza A, Garber SJ Sustainability and safety of an early-onset sepsis risk-stratification guideline for empiric antibiotics among very low birth weight infants , Pediatric Academic Societies: 2025


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