Karen Marie Puopolo, MD, PhD

she/her/hers
Neonatology and Newborn Services
Independent provider
Accepting new patients
Sees newborns through age 1 month
Neonatology and Newborn Services Pennsylvania Hospital

About me

  • Chief, Section on Newborn Medicine, Pennsylvania Hospital
  • Professor of Pediatrics (Neonatology & Newborn Services) at the Children's Hospital of Philadelphia

My education and training

  • Medical School: Tufts University School of Medicine
  • Residency: Boston Children's Hospital
  • Fellowship: Boston Children's Hospital

Insurance accepted

Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.

Locations

Penn Medicine hospital privileges

  • Pennsylvania Hospital: Has privileges to treat patients in the hospital.
Dr. Puopolo is an independent physician who is not employed by Penn Medicine.

Qualifications and experience

Treatments and Conditions

Research

Publications

Minor AA, Coggins SA, Sheffield JS, Puopolo KM, Milstone AM. A model for prevention: applying lessons from Group B Streptococcus to Staphylococcus aureus in very low birth weight neonates , J Perinatol, 46(5): 2026,689-691


May MF, Zevallos Barboza A, Garber SJ, Puopolo KM, Mukhopadhyay S, Flannery DD Long-term sustainability and safety of a delivery-based early-onset sepsis evaluation strategy for very low birth weight infants , J Perinatol, 46(5): 2026,865-867


Proaño A, Green M, Zevallos Barboza A, Greenberg RG, Puopolo KM, Flannery DD Anti-cytomegalovirus medications among very low birth weight infants in the United States from 2016 to 2023 , J Perinatol, 46(5): 2026,748-753


Zepeda F, Pulsifer A, Puopolo KM, Wade KC, Gabbert ML, Iannocone J, Hallman K, Anca R, Wheeler MN, Mukhopadhyay S Redefining Normal: Impact of Revised Glucose Thresholds on Neonatal Hypoglycemia , Pediatric Academic Societies: 2026


Flannery DD, Tan SM, Rysavy M, Greenberg RG, Sanchez PJ, Salas A, Mithal LB, Stoll BJ, Coggins SA, Puopolo, KM Sepsis Timing in Extreme Preterms (STEP) Study: A Cohort Study from the Neonatal Research Network , Pediatric Academic Societies: 2026


Flannery, DD, Edwards EM, Horbar JD, Schrag S, Coggins SA, Puopolo KM Pathogen-Specific Epidemiology of Neonatal Sepsis by Gestational Age in the Vermont-Oxford Network 2021-2024 , Pediatric Academic Societies: 2026


Devlin LA, Babineau DC, Merhar SL, DeMauro SB, Kraft WK, Lorch SA, Das A, McDonald SA, Rhodes E, Schmidt AF, Trochinski L, Crawford M, Sithisarn T, Leeman L, Kovatis KZ, Ambalavanan N, Smith RW, Telang S, Tioseco JA, McAllister JM, Wexelblatt SL, Muniyappa B, Williams PK, Adeniyi-Jones SC, Hill CD, Wright T, Sokol GM, Johnson L, Hall RW, Duncan SD, Puopolo K, Dummula K, Anderson-Berry A, Davis JM, Poindexter B, Young LW; HEAL Evaluation of Limited Pharmacotherapies for Neonatal Opioid Withdrawal Syndrome (HELP for NOWS) Consortium Symptom-Based Dosing for Neonatal Opioid Withdrawal: The OPTimize NOW Randomized Clinical Trial , JAMA: 2026,e265782


Laughon MM, Thomas SM, Watterberg KL, Kennedy KA, Keszler M, Ambalavanan N, Davis AS, Slaughter JL, Guillet R, Colaizy TT, Cotten CM, Dhawan MA, Bose CL, Talbert J, Smucny S, Benitz WE, Rysavy MA, Ohls RK, Baserga MC, DeMauro SB, Jaleel M, Jackson WM, Carlo WA, Puopolo KM, Hibbs AM, Katheria A, Sánchez PJ, D'Angio CT, Patel RM, Johnson BA, Chock VY, Bhatt AJ, Merhar SL, Moore R, Laptook AR, Ghavam S, Fuller J, Vyas-Read S, Kicklighter SD, Steinbrekera B, Anderson K, Reynolds AM, Wyckoff MH, Montoya C, Das A, Do B, Chang S, Higgins RD, Walsh MC; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Expectant Management vs Medication for Patent Ductus Arteriosus in Preterm Infants: The PDA Randomized Clinical Trial , JAMA, 335(15): 2026,1367


Eichenwald E, Corwin M, McEntire B, Knoblach S, Limperopoulos C, Kapse K, Kerr S, Heeren TC, Ikponmwonba C, Hunt CE; ICAF Study Group Intermittent hypoxia and caffeine in infants born preterm: the ICAF Randomized Clinical Trial , Arch Dis Child Fetal Neonatal Ed, 111(3): 2026,F249-F255


Coggins SA, Flannery DD, Puopolo KM, Mukhopadhyay S Association of Female Sex with Refusal of Newborn Vitamin K and Hepatitis B Vaccine Administration , Pediatric Academic Societies: 2026


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