John V. Bosso, MD
Otorhinolaryngology
Accepting new patients
Sees patients age 18 and up
Penn Otorhinolaryngology - Head and Neck Surgery Perelman
Make an appointmentCall 800-789-7366
Penn Medicine Provider

About me

  • Medical Director, Penn AERD Center
  • Director, Otorhinolaryngology Allergy Clinic
  • Professor of Clinical Otorhinolaryngology: Head and Neck Surgery

John V. Bosso, MD, allergist/immunologist and clinical professor, serves as medical director of the Aspirin Exacerbated Respiratory Disease (AERD or Samter’s triad) Center and director of the OTO-Allergy Clinic at Penn Medicine. He is one of the country’s most experienced AERD super-specialists with over 30 years of expertise in managing this challenging condition. He was one of the first Allergy/Immunology fellows to learn the techniques of aspirin desensitization and has subsequently successfully desensitized over 1,000 AERD patients in his career.

In addition to his practice, he has published extensively on the topic. His current research focuses on potential causes, molecular mechanisms and treatments of AERD. He has spoken at national otorhinolaryngology and allergy/immunology meetings and served on AERD expert panels. In addition, he is a proud supporter of the Samter’s Society, a support group for AERD sufferers. Dr. Bosso is a fellow of the American Academy of Allergy (FAAAAI), Asthma and Immunology, American College of Allergy, Asthma and Immunology (FACAAI) and College of Physicians of Philadelphia (FCPP).

Recognized in Philadelphia magazine's annual Top Docs issues for 2018, 2019, 2020, 2021, 2022, 2023 and 2024.

Education and training

  • Medical School: State University of New York at Buffalo
  • Residency: Staten Island University Hospital (North Site)
  • Fellowship: Scripps Green Hospital

What my patients think about me

Average Rating

579 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

October 2025
leader in his field
October 2025
very understanding of my allergy problems and gave me good advice on treatment.
October 2025
simply he's the best .
October 2025
he's solved a very complex problem alongside me

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
Dr. Bosso is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Yu AJ, Phung C, Kuppusamy K, Finuoli AM, Espinosa MC, Douglas JE, Kohanski MA, Adappa ND, Cohen NA, Bosso JV, Palmer JN, Workman AD. The Completeness of Surgery Index Predicts Success in CRSwNP With Asthma by SNOT-22 and Asthma Control Test. , Int Forum Allergy Rhinol : 2025

Herpin LP, Finuoli AM, Workman AD, Tang SH, Kuppusamy K, Kohanski MA, Palmer JN, Adappa ND, Douglas JE, Bosso JV. Factors Influencing Aspirin Therapy after Desensitization (ATAD) Tolerance in Aspirin-Exacerbated Respiratory Disease (AERD) Patients. , Ann Allergy Asthma Immunol.: 2025

Douglas JE, Tang SH, Mani A, Palmer JN, Adappa ND, Kohanski MA, Bosso JV. Institutional Experience in Aspirin-Exacerbated Respiratory Disease Yields Favorable Pulmonary and Sinonasal Outcomes. , Ear Nose Throat Journal: 2025

Sell EA, Tan LH, Renner DM, Douglas J, Lee RJ, Kohanski MA, Bosso JV, Kennedy DW, Palmer JN, Adappa ND, Weiss SR, Cohen NA. Common Cold Coronavirus 229E Induces Higher Interferon Stimulating Gene Responses in Human Nasal Epithelial Cells from Patients with Chronic Rhinosinusitis with Polyposis. , Am J Rhinol Allergy, 39(1): 2025,13-20

Asthana S, Workman AD, Lerner DK, Randell RM, Lopez DF, Kohanski MA, Palmer JN, Adappa ND, Douglas JE, Bosso JV. Social factors associated with aspirin desensitization and diagnosis age in aspirin-exacerbated respiratory disease. , Int Forum Allergy Rhinol., 15(1): 2025,89-92

Workman AD, Kuppusamy K, Lerner DK, Bosso JV, Douglas JE, Kohanski MA, Adappa ND, Palmer JN. Assessing adequacy of surgical extent in CRSwNP: The Completion of Surgery Index. , Int Forum Allergy Rhinol, 15(1): 2025,9-17

Jessica Migala The Little-Known Side Effect of Aspirin Asthma Sufferers Need to Know About , AARP Health Online: 2024

Workman Ad, Chang J, Lerner DK, Wilensky J, Montone KT, Bosso JV, Palmer JN, Adappa ND, Kohanski MA. "Utilizing Histopathology to Predict Success with Macrolide Therapy in CRS Patients". , Laryngoscope. , 134(3): 2024,1003-1004

Kohanski MA, Qatanani A, Lin C, Tan LH, Chang J, Corr A, Herzberg S, Adappa ND, Palmer JN, Reed DR, Bosso JV, Cohen NA Long-term aspirin desensitization has mucosal cytokine features of immune tolerance. , Allergy, 79(2): 2024,507-509

Buckey TM, Bosso JV "A Stepwise Approach to the adult immunodeficiency evaluation for the rhinologist". , Curr Opin Otolaryngol Head Neck Surg, 32(1): 2024,50-54