James C. Reynolds, MD, AGAF, FACP, FACG
Gastroenterology
Accepting new patients
Sees patients age 18 and up
Penn Gastroenterology Perelman
View 1 additional location
Make an appointmentCall 215-349-8222
Penn Medicine Provider

About me

  • Professor of Clinical Medicine (Gastroenterology)

Education and training

  • Medical School: University of Florida
  • Residency: NewYork-Presbyterian/Weill Cornell Medical Center
  • Fellowship: University of Pennsylvania Health System

What my patients think about me

Average Rating

669 reviews

Comments are submitted by patients and reflect their views and opinions. The comments are not endorsed by and do not necessarily reflect the views of Penn Medicine.

January 2026
he knows what he's talking about
December 2025
prescriptions not in the system
December 2025
dr. reynolds is very professional, thoughtful, and listens.
December 2025
very attentive and caring

Insurance accepted

My Locations

Penn Medicine hospital privileges

  • Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
  • Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Reynolds is a Penn Medicine physician.

Qualifications and experience

Treatments and Conditions

My research

Yetunde B Omotosho 1, James C Reynolds 2, Jack A Yanovski 3, Christina Tatsi 4 Body Composition and Fat Deposition in Children with Cushing Disease and Associations with Cardiometabolic Risk Factors , J Pediatr: 2025

Katharine K Hewlett 1, Amanda PeBenito 2, Aaron L Hecht 3, Connor Tiffany 1, Ceylan Tanes 4, Rochelle C Glover 1, Jibraan A Fawad 5, Elliot S Friedman 3, James C Reynolds Dietary Fiber Modulates the Window of Susceptibility to Clostridioides difficile Infection , Gastroenterology, 169(5): 2025,970-982

B E Rosenthal 1, B Zoll 1, H N Ryan 2, E Toto 2, J C Reynolds 2, N K Ahuja 2 Comparing Small Intestinal Bacterial Overgrowth and Intestinal Methanogen Overgrowth: A Single-Center Retrospective Cohort Study , j.gastha, 17(7): 2023,925-927

B Zoll, R Hernandez, T Keo, HN Ryan, E Toto, JC Reynolds, NK Ahuja Clinical associations with lactulose breath test results in a retrospective single-center cohort , Neurogastroenterology and Motility: 2021

B Zoll, R Hernandez, T Keo, HN Ryan, E Toto, JC Reynolds, NK Ahuja Symptomatic response to rifaximin monotherapy in intestinal methanogen overgrowth , Neurogastroenterology and Motility: 2021

S Javed, A Mastrangelo, HN Ryan, E Toto, T Keo, JC Reynolds, NK Ahuja Opiate use is associated with rectal hypersensitivity in patients undergoing anorectal manometry , Gastroenterology: 2021

R Kotcher, D Chait, J Heckert, TB Crowley, NK Ahuja, MR Mascarenhas, D McDonald-McGinn, J Reynolds Objective evidence of gastrointestinal disorders in patients with 22q11.2 deletion syndrome , American J Gastroenterology: 2019

IC Umana, S Ellison, R Hernandez, K Forde, JC Reynolds, NK Ahuja Clinical predictors of nutritional failure in patients with gastrointestinal dysmotility and/or functional gastrointestinal disorders , American J Gastroentrology: 2019

RE Kotcher, J Heckert, TB Crowley, N Ahuja, MR Mascarenhas, DM McDonald-McGinn, JC Reynolds Gastrointestinal (GI) features of 22Q11.2 deletion syndrome (22Q11.DS) often include chronic motility problems from childhood to adulthood , Gastroenterology: 2019

Ahuja NK, Reynolds JC Chronic constipation: practical approaches and novel therapies , The New Gastroenterologist, 3(1): 2018