- Collagenous colitis
- Crohn's disease
- J Pouch complication
- Lymphocytic colitis
- Microscopic colitis
- Pouchitis
- Ulcerative colitis (UC)
- Colonoscopy
James D. Lewis, MD, MSCE
Gastroenterology
Accepting new patients
Sees patients age 18 and up
Penn Digestive and Liver Health Center University City
Penn Medicine Provider
About me
- Chief of Gastroenterology, Penn Presbyterian Medical Center
- Vice Chief for Research (Clinical), Division of Gastroenterology and Hepatology
- Professor of Medicine (Gastroenterology)
- Professor of Epidemiology in Biostatistics and Epidemiology
I am Professor of Medicine and Epidemiology in the Division of Gastroenterology and Hepatology at the University of Pennsylvania’s Perelman School of Medicine. I currently serve as Chief of Gastroenterology at Penn Presbyterian Medical Center, Vice-Chief for Clinical Research in the Division of Gastroenterology and Hepatology, and Director of an NIH-funded T32 Training Grant in GI Epidemiology.
I have been a gastroenterologist and clinical investigator for nearly three decades. My clinical expertise is in the management of patients with inflammatory bowel diseases (IBD). Some cornerstones of my philosophy toward the care of patients with inflammatory bowel disease include the following:
- It is important for me to understand what aspects of my patient’s disease is most impacting their life and to look for solutions to these aspects.
- When possible, treatment decisions should be based on the best possible evidence.
- Shared decision making requires that I provide my patients with understandable information about complex situations. Shared decision making also requires that I understand my patients’ perspectives, goals and fears.
- It is important to revisit decisions that were made in the past to ensure it remains the correct decision today.
Yesterday’s research improved the care I can provide for patients with IBD today. As such, it is important that my patients have the opportunity to participate in today’s research so that the IBD care of the future will be even better. My own research focuses on the epidemiology of inflammatory bowel diseases and clinical trials.
Much of my research has been related to nutritional interventions for patients with IBD and to understanding factors that are associated with both favorable and undesirable outcomes.
My education and training
- University of Pennsylvania School of MedicineMedical School
- Yale-New Haven HospitalResidency
- University of Pennsylvania Health SystemFellowship
Spoken languages
English
English
Reviews
Insurance accepted
Please contact the practice and/or the member services department of your insurance company for specific details before receiving services. Providers may participate in some, but not all, products offered by a health plan; providers may also accept plans at some practice locations but not others.
- Aetna Advantra Cares D-SNP
- Aetna Advantra Credit Value
- Aetna Advantra Eagle HMO
- Aetna Advantra Eagle POS
- Aetna Advantra Premier Plus PPO
- Aetna Advantra Value
- Aetna Advantra Value Plus
- Aetna APCN Plus (Multi-Tier)
- Aetna Better Health Kids (CHIP) - DH Only
- Aetna Flexible Five
- Aetna Freedom Core
- Aetna Gold
- Aetna HMO
- Aetna Philly Prime
- Aetna POS
- Aetna PPO APCN
- Aetna Premier
- Aetna Premier Plus
- Aetna Savings Plus
- Aetna Signature Administrators
- Aetna Student Health Plan PPO
- Aetna Upfront Advantage
- First Health HMO
- First Health POS
- First Health PPO
- Meritain - Aramark (Other)
- Meritain - Aramark (Pennsylvania Premier Medical Plan)
- Americhealth Caritas of PA VIP - LGH Only
- Amerihealth Caritas (Transplant patients only)
- Amerihealth Caritas of PA - LGH Only
- Centivo EPO
- Cigna Healthcare EPO
- Cigna Healthcare HMO
- Cigna Healthcare POS
- Cigna Healthcare PPO
- Claim Watcher (Homestead/ INDECs) Open Access
- Clover Health Choice
- Clover Health Choice Value PPO
- Clover Health Classic HMO
- Clover Health Value
Locations
Penn Medicine hospital privileges
- Hospital of the University of Pennsylvania: Has privileges to treat patients in the hospital.
- Penn Presbyterian Medical Center: Has privileges to treat patients in the hospital.
Dr. Lewis is a Penn Medicine physician.
Qualifications and experience
- Gastroenterology, 1997
- AbbVie-Data Monitoring Committee for A Phase 2 Platform Basket Study Evaluating Advanced Therapies in Subjects with Moderately to Severely Active Crohn's Disease or Ulcerative Colitis, International
- American College of Gastroenterology, National
- American College of Physicians, National
- American Gastroenterological Association (Fellow), National
- American Society for Clinical Investigation, National
- Amgen, International
- Association of American Physicians, National
- Crohn's & Colitis Foundation, National
- Fortrea, International
- Gilead, International
- International Organization for the Study of Inflammatory Bowel Disease, International
- International Society of Pharmacoepidemiology, International
- Odyssey Therapeutics, International
- Oruka Therapeutics, International
- PCORI DSMB-Treat-to-Target of Endoscopic Remission in Patients with IBD in Symptomatic Remission:The QUOTIENT Trial, National
- Pfizer, International
- Sanofi, International
- Sanofi-DMC for A randomized, double-blind, placebo controlled, dose-finding study to assess the efficacy and safety of SAR443122 in adult patients with moderate to severe ulcerative colitis, International
- Spyre Therapeutics, International
- Inflammatory bowel disease (IBD) care
- Interventional and advanced endoscopy
- Recognized annually in Philadelphia Magazine's Top Docs issue from 2018 through 2025
Treatments and conditions
Research
Publications
Lewis James D, Scott Frank I, Brensinger Colleen M, Roy Jason A, Osterman Mark T, Mamtani Ronac, Bewtra Meenakshi, Chen Lang, Yun Huifeng, Xie Fenglong, Curtis Jeffrey R Increased Mortality Rates With Prolonged Corticosteroid Therapy When Compared With Antitumor Necrosis Factor-α-Directed Therapy for Inflammatory Bowel Disease. , The American journal of gastroenterology, 113(3): 2018,405-417
Khan Nabeel, Lee Helen, Trivedi Chinmay, Kavani Himanshu, Medvedeva Elina, Xie Dawei, Lewis James D, Yang Yu-Xiao Mortality Associated With Development of Squamous Cell Cancer in Patients With Inflammatory Bowel Disease Receiving Treatment With Thiopurines. , Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 17(11): 2019,2262-2268
Albenberg L, Brensinger C M, Wu Q, Gilroy E, Kappelman M D, Sandler R S, Lewis J D A Diet Low in Red and Processed Meat Does Not Reduce Rate of Crohn's Disease Flares. , Gastroenterology, 157(1): 2019,128-136.e5
Scott, F. I., Hans, A. K., Gerich, M. E., Fennimore, B., Mamtani, R., Vajravelu, R. K., Lewis, J. D. Identification of the Most Effective Position for Ustekinumab in Treatment Algorithms for Crohn''s Disease , Clin Gastroenterol Hepatol: 2020
Scott, F. I., Luo, M., Shah, Y., Lasch, K., Vajravelu, R. K., Mamtani, R., Fennimore, B., Gerich, M. E., Lewis, J. D. Identification of the Most Cost-effective Position of Vedolizumab Among the Available Biologic Drugs for the Treatment of Ulcerative Colitis , J Crohns Colitis, 14(5): 2020,575-587
Tanes C, Bittinger K, Gao Y, Friedman ES, Nessel L, Paladhi UR, Chau L, Panfen E, Fischbach MA, Braun J, Xavier RJ, Clish CB, Li H, Bushman FD, Lewis JD, Wu GD. Role of dietary fiber in the recovery of the human gut microbiome and its metabolome , Cell Host Microbe, ell Host Microbe: 2021,394-407
Lewis JD, Sandler R, Brotherton C, Brensinger C, Li H, Kappelman MD, Daniel SG, Bittinger K, Albenberg L, Valentine JF, Hanson J, Suskind D, Meyer A, Compher CW, Bewtra M, Saxena A, Dobes A, Cohen B, Flynn AD, Fischer M, Saha S, Swaminath A, Yacyshyn B, Scherl E, Horst S, Curtis JR, Braly K, Nessel L, McCauley M, McKeever L, Herfarth H; DINE-CD Study Group. A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease , Gastroenterology: 2021
Raffals LE, Saha S, Bewtra M, Norris C, Dobes A, Heller C, O'Charoen S, Fehlmann T, Sweeney S, Weaver A, Bishu S, Cross R, Dassopoulos T, Fischer M, Yarur A, Hudesman D, Parakkal D, Duerr R, Caldera F, Korzenik J, Pekow J, Wells K, Bohm M, Perera L, Kaur M, Ciorba M, Snapper S, Scoville EA, Dalal S, Wong U, Lewis JD. The Development and Initial Findings of A Study of a Prospective Adult Research Cohort with Inflammatory Bowel Disease (SPARC IBD) , Inflamm Bowel Dis, 28: 2021,192-199
Chassaing B, Compher C, Bonhomme B, Liu Q, Tian Y, Walters W, Nessel L, Delaroque C, Hao F, Gershuni V, Chau L, Ni J, Bewtra M, Albenberg L, Bretin A, McKeever L, Ley RE, Patterson AD, Wu GD, Gewirtz AT, Lewis JD. Randomized controlled-feeding study of dietary emulsifier carboxymethylcellulose reveals detrimental impacts on the gut microbiota and metabolome , Gastroenterology: 2021